7Z3T
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![BU of 7z3t by Molmil](/molmil-images/mine/7z3t) | Crystal structure of apo human Cathepsin L | 分子名称: | 1,2-ETHANEDIOL, Cathepsin L, DI(HYDROXYETHYL)ETHER, ... | 著者 | Reinke, P.Y.A, Falke, S, Lieske, J, Ewert, W, Loboda, J, Rahmani Mashhour, A, Hauser, M, Karnicar, K, Usenik, A, Lindic, N, Lach, M, Boehler, H, Beck, T, Cox, R, Chapman, H.N, Hinrichs, W, Turk, D, Guenther, S, Meents, A. | 登録日 | 2022-03-02 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections. Commun Biol, 6, 2023
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3LSV
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4W9M
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![BU of 4w9m by Molmil](/molmil-images/mine/4w9m) | AMPPNP bound Rad50 in complex with dsDNA | 分子名称: | DNA (5'-D(*GP*GP*TP*CP*GP*GP*TP*CP*AP*CP*CP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*GP*GP*TP*GP*AP*CP*CP*GP*AP*CP*C)-3'), Exonuclease, ... | 著者 | Rojowska, A, Lammens, K. | 登録日 | 2014-08-27 | 公開日 | 2015-01-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of the Rad50 DNA double-strand break repair protein in complex with DNA. Embo J., 33, 2014
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7Z5L
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6M8Z
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![BU of 6m8z by Molmil](/molmil-images/mine/6m8z) | Crystal structure of human DJ-1 without a modification on Cys-106 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Protein/nucleic acid deglycase DJ-1 | 著者 | Shumilin, I.A, Shabalin, I.G, Shumilina, S.V, Werenskjold, C, Utepbergenov, D, Minor, W. | 登録日 | 2018-08-22 | 公開日 | 2018-09-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1. Biochem. Biophys. Res. Commun., 504, 2018
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5U5S
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7OFU
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![BU of 7ofu by Molmil](/molmil-images/mine/7ofu) | Structure of SARS-CoV-2 Papain-like protease PLpro in complex with 3, 4-Dihydroxybenzoic acid, methyl ester | 分子名称: | CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ... | 著者 | Srinivasan, V, Ewert, W, Werner, N, Falke, S, Guenther, S, Reinke, P, Sprenger, J, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Wolf, M, Lieske, J, Koua, F, Ginn, H, Lane, T.J, Yefanov, O, Gelisio, L, Hakanpaeae, J, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Trost, F, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Wahab, A, Choudary, I, Turk, D, Hinrichs, W, Chapman, H.N, Meents, A, Betzel, C. | 登録日 | 2021-05-05 | 公開日 | 2021-05-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease. Commun Biol, 5, 2022
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7OFS
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![BU of 7ofs by Molmil](/molmil-images/mine/7ofs) | Structure of SARS-CoV-2 Papain-like protease PLpro in complex with 4-(2-hydroxyethyl)phenol | 分子名称: | 4-(2-hydroxyethyl)phenol, CHLORIDE ION, GLYCEROL, ... | 著者 | Srinivasan, V, Werner, N, Falke, S, Guenther, S, Reinke, P, Ewert, W, Sprenger, J, Koua, F, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Lieske, J, Ginn, H, Lane, T.J, Yefanov, O, Gelisio, L, Hakanpaeae, J, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Trost, F, Wolf, M, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Wahab, A, Choudary, I, Turk, D, Hinrichs, W, Chapman, H.N, Meents, A, Betzel, C. | 登録日 | 2021-05-05 | 公開日 | 2021-05-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease. Commun Biol, 5, 2022
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7OFT
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![BU of 7oft by Molmil](/molmil-images/mine/7oft) | Structure of SARS-CoV-2 Papain-like protease PLpro in complex with p-hydroxybenzaldehyde | 分子名称: | CHLORIDE ION, P-HYDROXYBENZALDEHYDE, POTASSIUM ION, ... | 著者 | Srinivasan, V, Werner, N, Falke, S, Guenther, S, Reinke, P, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Ewert, W, Sprenger, J, Lieske, J, Koua, F, Ginn, H, Lane, T.J, Wolf, M, Yefanov, O, Gelisio, L, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Trost, F, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Wahab, A, Choudary, I, Turk, D, Hinrichs, W, Chapman, H.N, Meents, A, Betzel, C. | 登録日 | 2021-05-05 | 公開日 | 2021-05-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease. Commun Biol, 5, 2022
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5KCX
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![BU of 5kcx by Molmil](/molmil-images/mine/5kcx) | Pim-1 kinase in Complex with a Selective N-substituted 7-azaindole Inhibitor | 分子名称: | 4-chloranyl-1-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]pyrrolo[2,3-b]pyridine-6-carboxamide, ACETATE ION, IMIDAZOLE, ... | 著者 | Mechin, I, McLean, L.R, Zhang, Y, Wang, R. | 登録日 | 2016-06-07 | 公開日 | 2017-07-19 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I. Bioorg. Med. Chem. Lett., 27, 2017
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8TW1
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![BU of 8tw1 by Molmil](/molmil-images/mine/8tw1) | Crystal structure of Lys2972, a phage endolysin targeting Streptococcus thermophilus | 分子名称: | Endolysin Lys2972, GLYCEROL, SODIUM ION | 著者 | Zhu, X, Moineau, S, Shi, R. | 登録日 | 2023-08-18 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Fermentation Practices Select for Thermostable Endolysins in Phages. Mol.Biol.Evol., 41, 2024
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5WJL
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5WJN
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![BU of 5wjn by Molmil](/molmil-images/mine/5wjn) | Crystal Structure of HLA-A*11:01-GTS3 | 分子名称: | Beta-2-microglobulin, GTS3 peptide, HLA class I histocompatibility antigen, ... | 著者 | Gras, S, Rossjohn, J. | 登録日 | 2017-07-23 | 公開日 | 2017-09-20 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8(+) T cell response. Nat. Immunol., 18, 2017
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8SK5
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![BU of 8sk5 by Molmil](/molmil-images/mine/8sk5) | Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, anti-SARS-CoV-2 receptor binding domain VHH | 著者 | Noland, C.L, Pande, K, Zhang, L, Zhou, H, Galli, J, Eddins, M, Gomez-Llorente, Y. | 登録日 | 2023-04-18 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants. Sci Rep, 13, 2023
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7AYY
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![BU of 7ayy by Molmil](/molmil-images/mine/7ayy) | Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, N-glycosylase/DNA lyase, ... | 著者 | Masuyer, G, Davies, J.R, Stenmark, P. | 登録日 | 2020-11-13 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science, 376, 2022
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7AYZ
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7AZ0
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5LX9
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![BU of 5lx9 by Molmil](/molmil-images/mine/5lx9) | CRYSTAL STRUCTURE OF HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX WITH A C18 FREE FATTY ACID AT 2.4 ANGSTROM RESOLUTION | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, HUMAN ADIPONECTIN RECEPTOR 2, OLEIC ACID, ... | 著者 | Vasiliauskaite-Brooks, I, Leyrat, C, Hoh, F, Granier, S. | 登録日 | 2016-09-20 | 公開日 | 2017-03-22 | 最終更新日 | 2017-04-12 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural insights into adiponectin receptors suggest ceramidase activity. Nature, 6, 2017
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5LWY
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![BU of 5lwy by Molmil](/molmil-images/mine/5lwy) | Revised crystal structure of the human adiponectin receptor 2 in complex with a C18 free fatty acid | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adiponectin receptor protein 2, GLYCEROL, ... | 著者 | Leyrat, C, Vasiliauskaite-Brooks, I, Granier, S. | 登録日 | 2016-09-19 | 公開日 | 2017-03-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural insights into adiponectin receptors suggest ceramidase activity. Nature, 6, 2017
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5LXA
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![BU of 5lxa by Molmil](/molmil-images/mine/5lxa) | CRYSTAL STRUCTURE OF HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX WITH A C18 FREE FATTY ACID AT 3.0 ANGSTROM RESOLUTION | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adiponectin receptor protein 2, Anti-CD30 moab Ki-4 scFv, ... | 著者 | Vasiliauskaite-Brooks, I, Leyrat, C, Hoh, F, Granier, S. | 登録日 | 2016-09-20 | 公開日 | 2017-03-22 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural insights into adiponectin receptors suggest ceramidase activity. Nature, 6, 2017
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5L0Q
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![BU of 5l0q by Molmil](/molmil-images/mine/5l0q) | Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mAb 8C7. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Disintegrin and metalloproteinase domain-containing protein 10, MAGNESIUM ION, ... | 著者 | Xu, K, Saha, N, Nikolov, D.B. | 登録日 | 2016-07-28 | 公開日 | 2016-11-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.759 Å) | 主引用文献 | An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J.Exp.Med., 213, 2016
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8ORC
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![BU of 8orc by Molmil](/molmil-images/mine/8orc) | Mus Musculus Acetylcholinesterase in complex with AL237 | 分子名称: | 1-[2-(dimethylamino)ethyl]-3-(2-methoxyphenyl)thiourea, 2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL, 2-(2-METHOXYETHOXY)ETHANOL, ... | 著者 | Ekstrom, F.E, Linusson, A. | 登録日 | 2023-04-13 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Enzyme Dynamics Determine Potency and Selectivity of Inhibitors Targeting Disease-Transmitting Mosquitoes To Be Published
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5LXG
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![BU of 5lxg by Molmil](/molmil-images/mine/5lxg) | Revised crystal structure of the human adiponectin receptor 1 in an open conformation | 分子名称: | Adiponectin receptor protein 1, SULFATE ION, V REGION HEAVY CHAIN, ... | 著者 | Leyrat, C, Vasiliauskaite-Brooks, I, Granier, S. | 登録日 | 2016-09-21 | 公開日 | 2017-03-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Structural insights into adiponectin receptors suggest ceramidase activity. Nature, 6, 2017
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8Q3U
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![BU of 8q3u by Molmil](/molmil-images/mine/8q3u) | Crystal structure of a fentanyl derivative in complex with human CA VII | 分子名称: | Carbonic anhydrase 7, GLYCEROL, ZINC ION, ... | 著者 | Alterio, V, Di Fiore, A, De Simone, G. | 登録日 | 2023-08-04 | 公開日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for mu Opioid receptor for Safer and long-lasting analgesia. Eur.J.Med.Chem., 260, 2023
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7NB1
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