7OFT

Structure of SARS-CoV-2 Papain-like protease PLpro in complex with p-hydroxybenzaldehyde

Summary for 7OFT

• Entry DOI: 10.2210/pdb7oft/pdb
• Related: 7OFS 7OFU 7nfv
• Descriptor: Papain-like protease nsp3, ZINC ION, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: papain-like protease sars-cov-2 hydrolase zinc binding protein, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• Total number of polymer chains: 1
• Total formula weight: 36220.85

Authors

Srinivasan, V.,Werner, N.,Falke, S.,Guenther, S.,Reinke, P.,Brognaro, H.,Ullah, N.,Andaleeb, H.,Perbandt, M.,Alves Franca, B.,Schwinzer, M.,Wang, M.,Ewert, W.,Sprenger, J.,Lieske, J.,Koua, F.,Ginn, H.,Lane, T.J.,Wolf, M.,Yefanov, O.,Gelisio, L.,Saouane, S.,Tolstikova, A.,Groessler, M.,Fleckenstein, H.,Trost, F.,Lorenzen, K.,Schubert, R.,Han, H.,Schmidt, C.,Brings, L.,Galchenkova, M.,Gevorkov, Y.,Li, C.,Perk, A.,Awel, S.,Wahab, A.,Choudary, I.,Turk, D.,Hinrichs, W.,Chapman, H.N.,Meents, A.,Betzel, C. (deposition date: 2021-05-05, release date: 2021-05-12, Last modification date: 2024-01-31)

• Primary citation: Srinivasan, V.,Brognaro, H.,Prabhu, P.R.,de Souza, E.E.,Gunther, S.,Reinke, P.Y.A.,Lane, T.J.,Ginn, H.,Han, H.,Ewert, W.,Sprenger, J.,Koua, F.H.M.,Falke, S.,Werner, N.,Andaleeb, H.,Ullah, N.,Franca, B.A.,Wang, M.,Barra, A.L.C.,Perbandt, M.,Schwinzer, M.,Schmidt, C.,Brings, L.,Lorenzen, K.,Schubert, R.,Machado, R.R.G.,Candido, E.D.,Oliveira, D.B.L.,Durigon, E.L.,Niebling, S.,Garcia, A.S.,Yefanov, O.,Lieske, J.,Gelisio, L.,Domaracky, M.,Middendorf, P.,Groessler, M.,Trost, F.,Galchenkova, M.,Mashhour, A.R.,Saouane, S.,Hakanpaa, J.,Wolf, M.,Alai, M.G.,Turk, D.,Pearson, A.R.,Chapman, H.N.,Hinrichs, W.,Wrenger, C.,Meents, A.,Betzel, C.; Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.; Commun Biol, 5:805-805, 2022; PubMed: 35953531; DOI: 10.1038/s42003-022-03737-7

Experimental method

X-RAY DIFFRACTION (1.95 Å)