Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
6AZW
DownloadVisualize
BU of 6azw by Molmil
IDO1/FXB-001116 crystal structure
分子名称: (2R)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide, Indoleamine 2,3-dioxygenase 1
著者Lewis, H.A, Lammens, A, Steinbacher, S.
登録日2017-09-13
公開日2018-03-21
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3WRO
DownloadVisualize
BU of 3wro by Molmil
Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication
分子名称: MANGANESE (II) ION, Non-capsid protein NS-1
著者Tewary, S.K, Zhao, H, Tang, L.
登録日2014-02-27
公開日2015-01-21
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding.
Virology, 476C, 2014
3WRN
DownloadVisualize
BU of 3wrn by Molmil
Minute virus of mice non-structural protein-1N-terminal nuclease domain reveals a unique Zn2+ coordination in the active site pocket and shows a novel mode of DNA recognition at the origin of replication
分子名称: Non-capsid protein NS-1, SODIUM ION, ZINC ION
著者Tewary, S.K, Zhao, H, Tang, L.
登録日2014-02-27
公開日2015-01-21
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Structures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin binding.
Virology, 476C, 2014
7Y8Y
DownloadVisualize
BU of 7y8y by Molmil
Structure of Cas7-11-crRNA-tgRNA in complex with TPR-CHAT
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (37-MER), ...
著者Wang, S, Guo, M, Zhu, Y, Huang, Z.
登録日2022-06-24
公開日2023-06-28
最終更新日2024-01-10
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT.
Cell Res., 32, 2022
4RE1
DownloadVisualize
BU of 4re1 by Molmil
Crystal structure of human TEAD1 and disulfide-engineered YAP
分子名称: CHLORIDE ION, Transcriptional enhancer factor TEF-1, Yorkie homolog
著者Xu, Z, Zhou, Z.
登録日2014-09-21
公開日2014-11-19
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.
Faseb J., 29, 2015
1DSS
DownloadVisualize
BU of 1dss by Molmil
STRUCTURE OF ACTIVE-SITE CARBOXYMETHYLATED D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM PALINURUS VERSICOLOR
分子名称: D-GLYCERALDEHYDE-3-PHOSPHATE-DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
著者Song, S, Lin, Z.
登録日1997-06-04
公開日1998-12-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structure of active site carboxymethylated D-glyceraldehyde-3-phosphate dehydrogenase from Palinurus versicolor.
J.Mol.Biol., 287, 1999
8T51
DownloadVisualize
BU of 8t51 by Molmil
Crystal structure of Fab 3.10C2 bound to TREM2
分子名称: 3.10C2 Fab heavy chain, 3.10C2 Fab light chain, ACETATE ION, ...
著者Hsu, P.L, Wallweber, H.
登録日2023-06-12
公開日2024-06-19
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining.
Nat Commun, 15, 2024
8T59
DownloadVisualize
BU of 8t59 by Molmil
Crystal structure of Para.09 bound to TREM2
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Para.09 heavy chain, ...
著者Wallweber, H, Hsu, P.L.
登録日2023-06-12
公開日2024-07-31
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining.
Nat Commun, 15, 2024
8TLR
DownloadVisualize
BU of 8tlr by Molmil
Crystal Structure of human HRAS G12C covalently bound to AMG 510
分子名称: AMG 510 (bound form), GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ...
著者Morstein, J, Guiley, K.Z, Shokat, K.M.
登録日2023-07-27
公開日2024-07-31
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.70003951 Å)
主引用文献Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
Cell, 187, 2024
4RFM
DownloadVisualize
BU of 4rfm by Molmil
ITK kinase domain in complex with compound 1 N-{1-[(1,1-dioxo-1-thian-2-yl)(phenyl)methyl]-1H- pyrazol-4-yl}-5,5-difluoro-5a-methyl-1H,4H,4aH,5H,5aH,6H-cyclopropa[f]indazole-3-carboxamide
分子名称: (4aS,5aR)-N-{1-[(R)-[(2R)-1,1-dioxidotetrahydro-2H-thiopyran-2-yl](phenyl)methyl]-1H-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide, Tyrosine-protein kinase ITK/TSK
著者McEwan, P.A, Barker, J.J, Eigenbrot, C.
登録日2014-09-26
公開日2015-04-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.
J.Med.Chem., 58, 2015
4EI4
DownloadVisualize
BU of 4ei4 by Molmil
JAK1 kinase (JH1 domain) in complex with compound 20
分子名称: (1R,3R)-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(8H)-yl)cyclohexanol, Tyrosine-protein kinase JAK1
著者Eigenbrot, C, Steffek, M.
登録日2012-04-04
公開日2012-07-04
最終更新日2024-11-27
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
J.Med.Chem., 55, 2012
4F08
DownloadVisualize
BU of 4f08 by Molmil
Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2
分子名称: 1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine, Tyrosine-protein kinase JAK2
著者Murray, J.M.
登録日2012-05-03
公開日2012-07-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2.
J.Med.Chem., 55, 2012
4F09
DownloadVisualize
BU of 4f09 by Molmil
Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2
分子名称: 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine, Tyrosine-protein kinase JAK2
著者Murray, J.M.
登録日2012-05-03
公開日2012-07-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2.
J.Med.Chem., 55, 2012
2PKG
DownloadVisualize
BU of 2pkg by Molmil
Structure of a complex between the A subunit of protein phosphatase 2A and the small t antigen of SV40
分子名称: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Small T antigen, ZINC ION
著者Jeffrey, P.D, Shi, Y.
登録日2007-04-17
公開日2007-05-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.
Nat.Struct.Mol.Biol., 14, 2007
2M5E
DownloadVisualize
BU of 2m5e by Molmil
Structure of the C-domain of Calcium-saturated Calmodulin bound to the IQ motif of NaV1.2
分子名称: CALCIUM ION, Calmodulin, Sodium channel protein type 2 subunit alpha
著者Fowler, C.A, Feldkamp, M.D, Yu, L, Shea, M.A.
登録日2013-02-21
公開日2014-07-23
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV1.2.
Biophys. Chem., 224, 2017
7SSM
DownloadVisualize
BU of 7ssm by Molmil
Crystal structure of human STING R232 in complex with compound 11
分子名称: 2-({[(8R)-pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino}methyl)-1-benzofuran-7-carboxylic acid, Stimulator of interferon genes protein
著者Sack, J.S, Critton, D.A.
登録日2021-11-11
公開日2022-02-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.
J.Med.Chem., 65, 2022
7WN7
DownloadVisualize
BU of 7wn7 by Molmil
Crystal structure of HearNPV P26
分子名称: CHLORIDE ION, SULFATE ION, p26
著者Kuang, W, Hu, Z, Gong, P.
登録日2022-01-17
公開日2022-11-23
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity.
Nat Commun, 13, 2022
4EHZ
DownloadVisualize
BU of 4ehz by Molmil
The Jak1 kinase domain in complex with inhibitor
分子名称: 1,2-ETHANEDIOL, 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine, Tyrosine-protein kinase JAK1
著者Lupardus, P.J, Steffek, M.
登録日2012-04-04
公開日2012-07-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.174 Å)
主引用文献Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
J.Med.Chem., 55, 2012
3RT0
DownloadVisualize
BU of 3rt0 by Molmil
Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA)
分子名称: Abscisic acid receptor PYL10, MAGNESIUM ION, Protein phosphatase 2C 16
著者Hao, Q, Yin, P, Li, W, Wang, L, Yan, C, Wang, J, Yan, N.
登録日2011-05-02
公開日2011-06-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.113 Å)
主引用文献The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins
Mol.Cell, 42, 2011
3RT2
DownloadVisualize
BU of 3rt2 by Molmil
Crystal structure of apo-PYL10
分子名称: Abscisic acid receptor PYL10
著者Hao, Q, Yin, P, Li, W, Wang, L, Yan, C, Wang, J, Yan, N.
登録日2011-05-02
公開日2011-06-22
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins
Mol.Cell, 42, 2011
2HV6
DownloadVisualize
BU of 2hv6 by Molmil
Crystal structure of the phosphotyrosyl phosphatase activator
分子名称: MAGNESIUM ION, Protein phosphatase 2A, regulatory subunit B
著者Chao, Y, Jeffrey, P.D, Shi, Y.
登録日2006-07-27
公開日2006-08-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure and mechanism of the phosphotyrosyl phosphatase activator.
Mol.Cell, 23, 2006
2HV7
DownloadVisualize
BU of 2hv7 by Molmil
Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein phosphatase 2A, regulatory subunit B
著者Chao, Y, Jeffrey, J.D, Shi, Y.
登録日2006-07-27
公開日2006-08-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and mechanism of the phosphotyrosyl phosphatase activator.
Mol.Cell, 23, 2006
7XSC
DownloadVisualize
BU of 7xsc by Molmil
Crystal structure of SARS-CoV-2 spike receptor binding domain bound with P5S-2B10
分子名称: P5S-2B10 Heavy chain, P5S-2B10 Light chain, Spike protein S1
著者Wang, X, Wang, Z, Lin, Z.
登録日2022-05-13
公開日2023-05-24
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants.
Nat.Immunol., 24, 2023
7CGS
DownloadVisualize
BU of 7cgs by Molmil
Crystal endo-deglycosylated hydroxynitrile lyase isozyme 5 mutant L343F from Prunus communis
分子名称: (R)-mandelonitrile lyase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zheng, Y.C, Li, F.L.
登録日2020-07-02
公開日2021-04-21
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A High-Throughput Screening Method for the Directed Evolution of Hydroxynitrile Lyase towards Cyanohydrin Synthesis.
Chembiochem, 22, 2021
8YXT
DownloadVisualize
BU of 8yxt by Molmil
Crystal structure of PtmB
分子名称: PROTOPORPHYRIN IX CONTAINING FE, PtmB
著者Zhang, Z.Y, Qu, X.D, Duan, B.R, Wei, G.Z.
登録日2024-04-02
公開日2024-11-20
最終更新日2025-01-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A nucleobase-driven P450 peroxidase system enables regio- and stereo-specific formation of C─C and C─N bonds.
Proc.Natl.Acad.Sci.USA, 121, 2024

238582

件を2025-07-09に公開中

PDB statisticsPDBj update infoContact PDBjnumon