3OUL
 
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6XJF
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6XDM
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6PLN
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6PWW
 | | Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome | | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | | 登録日 | 2019-07-23 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019
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6PWX
 | | Cryo-EM structure of RbBP5 bound to the nucleosome | | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | | 登録日 | 2019-07-23 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019
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1LAN
 | | LEUCINE AMINOPEPTIDASE COMPLEX WITH L-LEUCINAL | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, LEUCINE, LEUCINE AMINOPEPTIDASE, ... | | 著者 | Straeter, N, Lipscomb, W.N. | | 登録日 | 1995-08-11 | | 公開日 | 1995-10-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Two-metal ion mechanism of bovine lens leucine aminopeptidase: active site solvent structure and binding mode of L-leucinal, a gem-diolate transition state analogue, by X-ray crystallography.
Biochemistry, 34, 1995
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1LAM
 | | LEUCINE AMINOPEPTIDASE (UNLIGATED) | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, CARBONATE ION, LEUCINE AMINOPEPTIDASE, ... | | 著者 | Straeter, N, Lipscomb, W.N. | | 登録日 | 1995-08-11 | | 公開日 | 1995-10-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Two-metal ion mechanism of bovine lens leucine aminopeptidase: active site solvent structure and binding mode of L-leucinal, a gem-diolate transition state analogue, by X-ray crystallography.
Biochemistry, 34, 1995
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4QBS
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1A77
 | | FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII | | 分子名称: | FLAP ENDONUCLEASE-1 PROTEIN, MAGNESIUM ION | | 著者 | Hwang, K.Y, Baek, K, Kim, H, Cho, Y. | | 登録日 | 1998-03-20 | | 公開日 | 1999-08-03 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
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1A76
 | | FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII | | 分子名称: | FLAP ENDONUCLEASE-1 PROTEIN, MANGANESE (II) ION | | 著者 | Hwang, K.Y, Baek, K, Kim, H, Cho, Y. | | 登録日 | 1998-03-20 | | 公開日 | 1999-08-03 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
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4QBR
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4QBQ
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4EN1
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8HFB
 | | Evolved variant of quercetin 2,4-dioxygenase from Bacillus subtilis | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, NICKEL (II) ION, ... | | 著者 | Eom, H, Song, W.J. | | 登録日 | 2022-11-10 | | 公開日 | 2023-03-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Underlying Role of Hydrophobic Environments in Tuning Metal Elements for Efficient Enzyme Catalysis.
J.Am.Chem.Soc., 145, 2023
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5VCH
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5VKT
 | | Cinnamyl alcohol dehydrogenases (SbCAD4) from Sorghum bicolor (L.) Moench | | 分子名称: | ACETATE ION, Cinnamyl alcohol dehydrogenases (SbCAD4), D-MALATE, ... | | 著者 | Walker, A.M, Jun, S.Y, Kang, C. | | 登録日 | 2017-04-22 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.827 Å) | | 主引用文献 | The Enzyme Activity and Substrate Specificity of Two Major Cinnamyl Alcohol Dehydrogenases in Sorghum (Sorghum bicolor), SbCAD2 and SbCAD4.
Plant Physiol., 174, 2017
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6VAT
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6VC7
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6VDF
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7T63
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1LCP
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2IJN
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7CM0
 | | Crystal structure of a glutaminyl cyclase in complex with NHV-1009 | | 分子名称: | 1-(cyclopentylmethyl)-1-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]urea, Glutaminyl-peptide cyclotransferase, ZINC ION | | 著者 | Lee, J.W, Song, J.Y, Jang, T.H, Ha, J.H. | | 登録日 | 2020-07-23 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Eur.J.Med.Chem., 226, 2021
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7KNW
 | | Crystal structure of SND1 in complex with C-26-A2 | | 分子名称: | 5-chloro-2-methoxy-N-([1,2,4]triazolo[1,5-a]pyridin-8-yl)benzene-1-sulfonamide, GLYCEROL, Staphylococcal nuclease domain-containing protein 1 | | 著者 | Kang, Y. | | 登録日 | 2020-11-06 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
Nat Cancer, 3, 2022
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