7CM0

Crystal structure of a glutaminyl cyclase in complex with NHV-1009

Summary for 7CM0

Entry DOI	10.2210/pdb7cm0/pdb
Descriptor	Glutaminyl-peptide cyclotransferase, 1-(cyclopentylmethyl)-1-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]-3-[3-(5-methylimidazol-1-yl)propyl]urea, ZINC ION, ... (4 entities in total)
Functional Keywords	glutaminyl cyclases (qcs), alzheimer disease, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	151857.19
Authors	Lee, J.W.,Song, J.Y.,Jang, T.H.,Ha, J.H. (deposition date: 2020-07-23, release date: 2021-12-22, Last modification date: 2023-11-29)
Primary citation	Van Manh, N.,Hoang, V.H.,Ngo, V.T.H.,Ann, J.,Jang, T.H.,Ha, J.H.,Song, J.Y.,Ha, H.J.,Kim, H.,Kim, Y.H.,Lee, J.,Lee, J. Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design. Eur.J.Med.Chem., 226:113819-113819, 2021 Cited by PubMed: 34536669 DOI: 10.1016/j.ejmech.2021.113819 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation