7CM0

Crystal structure of a glutaminyl cyclase in complex with NHV-1009

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0008270	molecular_function	zinc ion binding
A	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
A	0016746	molecular_function	acyltransferase activity
A	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
A	0035580	cellular_component	specific granule lumen
A	0036211	biological_process	protein modification process
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0008270	molecular_function	zinc ion binding
B	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
B	0016746	molecular_function	acyltransferase activity
B	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
B	0035580	cellular_component	specific granule lumen
B	0036211	biological_process	protein modification process
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0008270	molecular_function	zinc ion binding
C	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
C	0016746	molecular_function	acyltransferase activity
C	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
C	0035580	cellular_component	specific granule lumen
C	0036211	biological_process	protein modification process
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0008270	molecular_function	zinc ion binding
D	0016603	molecular_function	glutaminyl-peptide cyclotransferase activity
D	0016746	molecular_function	acyltransferase activity
D	0017186	biological_process	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
D	0035580	cellular_component	specific granule lumen
D	0036211	biological_process	protein modification process
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:18072935

Chain	Residue	Details
B	GLU201
B	ASP248
C	GLU201
C	ASP248
D	GLU201
D	ASP248
A	GLU201
A	ASP248

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:16135565, ECO:0000269|PubMed:18072935, ECO:0000269|PubMed:21288892, ECO:0000269|PubMed:21671571, ECO:0007744|PDB:2AFM, ECO:0007744|PDB:2AFO, ECO:0007744|PDB:2AFS, ECO:0007744|PDB:2AFU, ECO:0007744|PDB:2AFW, ECO:0007744|PDB:2AFX, ECO:0007744|PDB:2AFZ, ECO:0007744|PDB:2ZED, ECO:0007744|PDB:2ZEE, ECO:0007744|PDB:2ZEF, ECO:0007744|PDB:2ZEG, ECO:0007744|PDB:2ZEH, ECO:0007744|PDB:2ZEL, ECO:0007744|PDB:2ZEM, ECO:0007744|PDB:2ZEN, ECO:0007744|PDB:2ZEO, ECO:0007744|PDB:2ZEP, ECO:0007744|PDB:3PBB, ECO:0007744|PDB:3PBE, ECO:0007744|PDB:3SI0, ECO:0007744|PDB:4YU9, ECO:0007744|PDB:4YWY

Chain	Residue	Details
B	ASP159
B	GLU202
B	HIS330
C	ASP159
C	GLU202
C	HIS330
D	ASP159
D	GLU202
D	HIS330
A	ASP159
A	GLU202
A	HIS330

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21671571

Chain	Residue	Details
C	ASN49
D	ASN49
A	ASN49
B	ASN49

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN296
B	ASN296
C	ASN296
D	ASN296

---