3LL4
| Structure of the H13A mutant of Ykr043C in complex with fructose-1,6-bisphosphate | Descriptor: | 1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM), Uncharacterized protein YKR043C | Authors: | Singer, A, Xu, X, Cui, H, Dong, A, Stogios, P.J, Edwards, A.M, Joachimiak, A, Savchenko, A, Yakunin, A.F, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2010-01-28 | Release date: | 2010-03-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structure and activity of the metal-independent fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae. J.Biol.Chem., 285, 2010
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3LG2
| A Ykr043C/ fructose-1,6-bisphosphate product complex following ligand soaking | Descriptor: | PHOSPHATE ION, Uncharacterized protein YKR043C | Authors: | Singer, A, Xu, X, Cui, H, Dong, A, Edwards, A.M, Joachimiak, A, Yakunin, A.F, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2010-01-19 | Release date: | 2010-03-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure and activity of the metal-independent fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae. J.Biol.Chem., 285, 2010
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3D1R
| Structure of E. coli GlpX with its substrate fructose 1,6-bisphosphate | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, CALCIUM ION, CHLORIDE ION, ... | Authors: | Singer, A, Skarina, T, Dong, A, Brown, G, Joachimiak, A, Edwards, A.M, Yakunin, A.F, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-05-06 | Release date: | 2008-12-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and Biochemical Characterization of the Type II Fructose-1,6-bisphosphatase GlpX from Escherichia coli. J.Biol.Chem., 284, 2009
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3K29
| Structure of a putative YscO homolog CT670 from Chlamydia trachomatis | Descriptor: | Putative uncharacterized protein | Authors: | Lam, R, Singer, A, Skarina, T, Onopriyenko, O, Bochkarev, A, Brunzelle, J.S, Edwards, A.M, Anderson, W.F, Chirgadze, N.Y, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2009-09-29 | Release date: | 2009-10-13 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and protein-protein interaction studies on Chlamydia trachomatis protein CT670 (YscO Homolog). J.Bacteriol., 192, 2010
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2A36
| Solution structure of the N-terminal SH3 domain of DRK | Descriptor: | Protein E(sev)2B | Authors: | Forman-Kay, J.D, Bezsonova, I, Singer, A, Choy, W.-Y, Tollinger, M. | Deposit date: | 2005-06-23 | Release date: | 2005-12-13 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Comparison of the Unstable drkN SH3 Domain and a Stable Mutant Biochemistry, 44, 2005
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2A37
| Solution structure of the T22G mutant of N-terminal SH3 domain of DRK (DRKN SH3 DOMAIN) | Descriptor: | Protein E(sev)2B | Authors: | Bezsonova, I, Singer, A, Choy, W.-Y, Tollinger, M, Forman-Kay, J.D. | Deposit date: | 2005-06-23 | Release date: | 2005-12-13 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Comparison of the Unstable drkN SH3 Domain and a Stable Mutant Biochemistry, 44, 2005
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6C68
| MHC-independent t cell receptor A11 | Descriptor: | T-cell receptor alpha chain, T-cell receptor beta chain | Authors: | Lu, J, Van Laethem, F, Saba, I, Chu, J, Bhattacharya, A, Love, N.C, Tikhonova, A, Radaev, S, Sun, X, Ko, A, Arnon, T, Shifrut, E, Friedman, N, Weng, N, Singer, A, Sun, P.D. | Deposit date: | 2018-01-18 | Release date: | 2019-01-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155. J Immunol., 204, 2020
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7SP5
| Crystal Structure of a Eukaryotic Phosphate Transporter | Descriptor: | PHOSPHATE ION, Phosphate transporter, nonyl beta-D-glucopyranoside | Authors: | Stroud, R.M, Pedersen, B.P, Kumar, H, Waight, A.B, Risenmay, A.J, Roe-Zurz, Z, Chau, B.H, Schlessinger, A, Bonomi, M, Harries, W, Sali, A, Johri, A.K, Finer-Moore, J. | Deposit date: | 2021-11-02 | Release date: | 2021-11-17 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of a eukaryotic phosphate transporter. Nature, 496, 2013
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7BCS
| ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation. | Descriptor: | (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BCQ
| ASCT2 in the presence of the inhibitor Lc-BPE (position "up") in the outward-open conformation. | Descriptor: | 4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BCT
| ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation. | Descriptor: | Neutral amino acid transporter B(0) | Authors: | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | Deposit date: | 2020-12-21 | Release date: | 2021-09-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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6Q0N
| Structure of the Erbin PDB domain in complex with a high-affinity peptide | Descriptor: | Erbin, peptide | Authors: | Singer, A.U, Teyra, J, Ernst, A, Sicheri, F, Sidhu, S.S. | Deposit date: | 2019-08-02 | Release date: | 2019-11-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities. Protein Sci., 29, 2020
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6Q0M
| Structure of Erbin PDZ derivative E-14 with a high-affinity peptide | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Singer, A.U, Teyra, J, Ernst, A, Sicheri, F, Sidhu, S.S. | Deposit date: | 2019-08-02 | Release date: | 2019-11-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities. Protein Sci., 29, 2020
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6Q0U
| Structure of the Erbin PDZ variant E-6a with a high-affinity C-terminal peptide | Descriptor: | 1,2-ETHANEDIOL, Erbin, peptide | Authors: | Singer, A.U, Teyra, J, Ernst, A, Sicheri, F, Sidhu, S.S. | Deposit date: | 2019-08-02 | Release date: | 2019-11-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities. Protein Sci., 29, 2020
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6UBH
| Structure of the MM7 Erbin PDZ variant in complex with a high-affinity peptide | Descriptor: | Erbin, SODIUM ION, peptide | Authors: | Singer, A.U, Teyra, J, McLaughlin, M, Ernst, A, Sicheri, F, Sidhu, S.S. | Deposit date: | 2019-09-11 | Release date: | 2020-07-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Comprehensive Assessment of the Relationship Between Site -2 Specificity and Helix alpha 2 in the Erbin PDZ Domain. J.Mol.Biol., 433, 2021
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7LUL
| Structure of the MM2 Erbin PDZ variant in complex with a high-affinity peptide | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | Authors: | Singer, A.U, Teyra, J, McLaughlin, M, Ernst, A, Sicheri, F, Sidhu, S.S. | Deposit date: | 2021-02-22 | Release date: | 2021-07-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Comprehensive Assessment of the Relationship Between Site -2 Specificity and Helix alpha 2 in the Erbin PDZ Domain. J.Mol.Biol., 433, 2021
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8CX9
| Structure of the SARS-COV2 PLpro (C111S) in complex with a dimeric Ubv that inhibits activity by an unusual allosteric mechanism | Descriptor: | BROMIDE ION, CHLORIDE ION, Papain-like protease nsp3, ... | Authors: | Singer, A.U, Slater, C.L, Patel, A, Russel, R, Mark, B.L, Sidhu, S.S. | Deposit date: | 2022-05-20 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. Plos Pathog., 18, 2022
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3QVM
| The structure of olei00960, a hydrolase from Oleispira antarctica | Descriptor: | CALCIUM ION, CHLORIDE ION, Olei00960, ... | Authors: | Singer, A.U, Kagan, O, Kim, Y, Edwards, A.M, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-02-25 | Release date: | 2011-04-13 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica. Nat Commun, 4, 2013
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2KKX
| Solution Structure of C-terminal domain of reduced NleG2-3 (residues 90-191) from Pathogenic E. coli O157:H7. Northeast Structural Genomics Consortium and Midwest Center for Structural Genomics target ET109A | Descriptor: | Uncharacterized protein ECs2156 | Authors: | Wu, B, Yee, A, Fares, C, Lemak, A, Semest, A, Claude, M, Singer, A, Edwards, A, Savchenko, A, Montelione, G.T, Joachimiak, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Ontario Centre for Structural Proteomics (OCSP), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-06-29 | Release date: | 2009-08-25 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases. Plos Pathog., 6, 2010
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2KKY
| Solution Structure of C-terminal domain of oxidized NleG2-3 (residue 90-191) from Pathogenic E. coli O157:H7. Northeast Structural Genomics Consortium and Midwest Center for Structural Genomics target ET109A | Descriptor: | Uncharacterized protein ECs2156 | Authors: | Wu, B, Yee, A, Fares, C, Lemak, A, Semest, A, Claude, M, Singer, A, Edwards, A, Savchenko, A, Montelione, G.T, Joachimiak, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Midwest Center for Structural Genomics (MCSG), Ontario Centre for Structural Proteomics (OCSP) | Deposit date: | 2009-06-29 | Release date: | 2009-08-25 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases. Plos Pathog., 6, 2010
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3I4Q
| Structure of a putative inorganic pyrophosphatase from the oil-degrading bacterium Oleispira antarctica | Descriptor: | APC40078, SODIUM ION | Authors: | Singer, A.U, Evdokimova, E, Kagan, O, Edwards, A.M, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-07-02 | Release date: | 2009-07-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica. Nat Commun, 4, 2013
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2QH1
| Structure of TA289, a CBS-rubredoxin-like protein, in its Fe+2-bound state | Descriptor: | FE (II) ION, Hypothetical protein Ta0289 | Authors: | Singer, A.U, Proudfoot, M, Brown, G, Xu, L, Savchenko, A, Yakunin, A.F, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2007-06-29 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biochemical and structural characterization of a novel family of cystathionine beta-synthase domain proteins fused to a Zn ribbon-like domain. J.Mol.Biol., 375, 2008
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2Q16
| Structure of the E. coli inosine triphosphate pyrophosphatase RgdB in complex with ITP | Descriptor: | CALCIUM ION, HAM1 protein homolog, INOSINE 5'-TRIPHOSPHATE, ... | Authors: | Singer, A.U, Lam, R, Proudfoot, M, Skarina, T, Savchenko, A, Yakunin, A.F. | Deposit date: | 2007-05-23 | Release date: | 2008-02-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli. J.Mol.Biol., 374, 2007
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2PYU
| Structure of the E. coli inosine triphosphate pyrophosphatase RgdB in complex with IMP | Descriptor: | 1,2-ETHANEDIOL, INOSINIC ACID, Inosine Triphosphate Pyrophosphatase RdgB | Authors: | Singer, A.U, Proudfoot, M, Skarina, T, Savchenko, A, Yakunin, A.F. | Deposit date: | 2007-05-16 | Release date: | 2008-03-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli. J.Mol.Biol., 374, 2007
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3DRW
| Crystal Structure of a Phosphofructokinase from Pyrococcus horikoshii OT3 with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, ADP-specific phosphofructokinase, SODIUM ION | Authors: | Singer, A.U, Skarina, T, Kochinyan, S, Brown, G, Cuff, M.E, Edwards, A.M, Joachimiak, A, Savchenko, A, Yakunin, A.F, Jia, Z, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-07-11 | Release date: | 2008-12-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | ADP-dependent 6-phosphofructokinase from Pyrococcus horikoshii OT3: structure determination and biochemical characterization of PH1645. J.Biol.Chem., 284, 2009
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