6RLV
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![BU of 6rlv by Molmil](/molmil-images/mine/6rlv) | Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine | Descriptor: | 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, GLYCEROL, MALONATE ION, ... | Authors: | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2019-05-02 | Release date: | 2020-01-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
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7YP8
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![BU of 7yp8 by Molmil](/molmil-images/mine/7yp8) | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Leucyl-sulfamoyl 3-deazaadenosine | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2022-08-02 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The essential role of a structured water in base recognition of Class II aminoacyl-tRNA synthetases To be published
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8HFM
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![BU of 8hfm by Molmil](/molmil-images/mine/8hfm) | Crystal Structure of Mycobacterium smegmatis MshC | Descriptor: | CALCIUM ION, L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, ZINC ION | Authors: | Pang, L, Weeks, S.D, Strelkov, S.V. | Deposit date: | 2022-11-11 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides. Int J Mol Sci, 23, 2022
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8HFO
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![BU of 8hfo by Molmil](/molmil-images/mine/8hfo) | Crystal Structure of Mycobacterium smegmatis MshC in Complex with Compound 7d | Descriptor: | CALCIUM ION, L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, N-[(3M)-3-(thiophen-2-yl)benzene-1-sulfonyl]-L-cysteinamide, ... | Authors: | Pang, L, Weeks, S.D, Strelkov, S.V. | Deposit date: | 2022-11-11 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides. Int J Mol Sci, 23, 2022
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8HFN
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![BU of 8hfn by Molmil](/molmil-images/mine/8hfn) | Crystal Structure of Mycobacterium smegmatis MshC in Complex with Compound 7b | Descriptor: | CALCIUM ION, L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, N-[(3M)-3-(6-methoxypyridin-3-yl)benzene-1-sulfonyl]-L-cysteinamide, ... | Authors: | Pang, L, Weeks, S.D, Strelkov, S.V. | Deposit date: | 2022-11-11 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides. Int J Mol Sci, 23, 2022
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6RLU
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![BU of 6rlu by Molmil](/molmil-images/mine/6rlu) | Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)cytidine | Descriptor: | 5'-O-(N-(L-seryl)-sulfamoyl)cytidine, GLYCEROL, MALONATE ION, ... | Authors: | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2019-05-02 | Release date: | 2020-01-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
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7NU8
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![BU of 7nu8 by Molmil](/molmil-images/mine/7nu8) | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with the Reaction Intermediate Leu-AMP | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Leucine--tRNA ligase, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NUB
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![BU of 7nub by Molmil](/molmil-images/mine/7nub) | Crystal Structure of Neisseria gonorrhoeae LeuRS L550G mutant in Complex with the Reaction Intermediate Leu-AMP | Descriptor: | Leucine--tRNA ligase, MAGNESIUM ION, ZINC ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NU3
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![BU of 7nu3 by Molmil](/molmil-images/mine/7nu3) | Crystal Structure of Neisseria gonorrhoeae LeuRS E169G mutant in Complex with ATP and L-leucinol | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NTZ
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![BU of 7ntz by Molmil](/molmil-images/mine/7ntz) | Crystal Structure of Neisseria gonorrhoeae LeuRS L550A mutant in Complex with the Reaction Intermediate Leu-AMP | Descriptor: | Leucine--tRNA ligase, MAGNESIUM ION, ZINC ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NUC
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![BU of 7nuc by Molmil](/molmil-images/mine/7nuc) | Crystal Structure of Neisseria gonorrhoeae LeuRS L550G mutant in Complex with ATP and L-leucinol | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NU2
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![BU of 7nu2 by Molmil](/molmil-images/mine/7nu2) | Crystal Structure of Neisseria gonorrhoeae LeuRS E169G mutant in Complex with the Reaction Intermediate Leu-AMP | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Leucine--tRNA ligase, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NU7
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![BU of 7nu7 by Molmil](/molmil-images/mine/7nu7) | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with ATP in Conformation 2 | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Leucine--tRNA ligase, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NUA
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![BU of 7nua by Molmil](/molmil-images/mine/7nua) | |
7NU5
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![BU of 7nu5 by Molmil](/molmil-images/mine/7nu5) | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with L-leucine | Descriptor: | LEUCINE, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NTY
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![BU of 7nty by Molmil](/molmil-images/mine/7nty) | |
7NU1
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![BU of 7nu1 by Molmil](/molmil-images/mine/7nu1) | |
7NU4
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![BU of 7nu4 by Molmil](/molmil-images/mine/7nu4) | Crystal Structure of Neisseria gonorrhoeae LeuRS | Descriptor: | 1,2-ETHANEDIOL, Leucine--tRNA ligase, MAGNESIUM ION, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NU6
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![BU of 7nu6 by Molmil](/molmil-images/mine/7nu6) | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with ATP in Conformation 1 | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Leucine--tRNA ligase, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NU9
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![BU of 7nu9 by Molmil](/molmil-images/mine/7nu9) | Crystal Structure of Neisseria gonorrhoeae LeuRS in Complex with ATP and L-leucinol | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7NU0
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![BU of 7nu0 by Molmil](/molmil-images/mine/7nu0) | Crystal Structure of Neisseria gonorrhoeae LeuRS L550A mutant in Complex with ATP and L-leucinol | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-4-METHYL-PENTAN-1-OL, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Pang, L, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-03-11 | Release date: | 2022-09-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5, 2022
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7OSZ
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![BU of 7osz by Molmil](/molmil-images/mine/7osz) | Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4d | Descriptor: | 3-[(2-methylphenyl)methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ... | Authors: | Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-06-09 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies. Int J Mol Sci, 22, 2021
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7OT0
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![BU of 7ot0 by Molmil](/molmil-images/mine/7ot0) | Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4h | Descriptor: | 3-[(2-chlorophenyl)methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ... | Authors: | Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-06-09 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies. Int J Mol Sci, 22, 2021
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7OSY
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![BU of 7osy by Molmil](/molmil-images/mine/7osy) | Human Prolyl-tRNA Synthetase in Complex with L-proline | Descriptor: | Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ... | Authors: | Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-06-09 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies. Int J Mol Sci, 22, 2021
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7OT1
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![BU of 7ot1 by Molmil](/molmil-images/mine/7ot1) | Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 3c | Descriptor: | Bifunctional glutamate/proline--tRNA ligase, PROLINE, STRONTIUM ION, ... | Authors: | Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D. | Deposit date: | 2021-06-09 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies. Int J Mol Sci, 22, 2021
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