7NTZ

Crystal Structure of Neisseria gonorrhoeae LeuRS L550A mutant in Complex with the Reaction Intermediate Leu-AMP

Summary for 7NTZ

Entry DOI	10.2210/pdb7ntz/pdb
Related	7NTY 7NU0
Descriptor	Leucine--tRNA ligase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (2~{S})-2-azanyl-4-methyl-pentanoate, ZINC ION, ... (5 entities in total)
Functional Keywords	protein-ligand complex, rossmann fold, trna synthetase, ligase
Biological source	Neisseria gonorrhoeae
Total number of polymer chains	1
Total formula weight	98693.36
Authors	Pang, L.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2021-03-11, release date: 2022-08-31, Last modification date: 2024-01-31)
Primary citation	Pang, L.,Zanki, V.,Strelkov, S.V.,Van Aerschot, A.,Gruic-Sovulj, I.,Weeks, S.D. Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip. Commun Biol, 5:883-883, 2022 Cited by PubMed: 36038645 DOI: 10.1038/s42003-022-03825-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation