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1NYF
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BU of 1nyf by Molmil
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE
Descriptor: FYN
Authors:Morton, C.J, Pugh, D.J.R, Campbell, I.D.
Deposit date:1996-04-22
Release date:1996-11-08
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure and peptide binding of the SH3 domain from human Fyn.
Structure, 4, 1996
1NYG
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BU of 1nyg by Molmil
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, FAMILY OF 20 STRUCTURES
Descriptor: FYN
Authors:Morton, C.J, Pugh, D.J.R, Campbell, I.D.
Deposit date:1996-04-22
Release date:1996-11-08
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure and peptide binding of the SH3 domain from human Fyn.
Structure, 4, 1996
6XD4
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BU of 6xd4 by Molmil
CDC-like protein
Descriptor: ACETATE ION, Hemolysin, SODIUM ION
Authors:Morton, C.J, Parker, M.W, Lawrence, S.L, Johnstone, B.A, Tweten, R.K.
Deposit date:2020-06-09
Release date:2021-04-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins.
Mbio, 11, 2020
3VDD
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BU of 3vdd by Molmil
Structure of HRV2 capsid complexed with antiviral compound BTA798
Descriptor: 3-ethoxy-6-{2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy}-1,2-benzoxazole, Protein VP1, Protein VP2, ...
Authors:Morton, C.J, Feil, S.C, Parker, M.W.
Deposit date:2012-01-05
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.
ACS Med Chem Lett, 3, 2012
5IMT
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BU of 5imt by Molmil
Toxin receptor complex
Descriptor: CD59 glycoprotein, COPPER (II) ION, Intermedilysin, ...
Authors:Morton, C.J, Lawrence, S.L, Feil, S.C, Parker, M.W.
Deposit date:2016-03-06
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7001 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
7LXT
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BU of 7lxt by Molmil
Structure of Plasmodium falciparum 20S proteasome with bound bortezomib
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Morton, C.J, Metcalfe, R.D, Liu, B, Xie, S.C, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2021-03-05
Release date:2021-09-22
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc.Natl.Acad.Sci.USA, 118, 2021
6NAL
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BU of 6nal by Molmil
Crystal Structure of Gram Negative Toxin
Descriptor: IMIDAZOLE, TETRAETHYLENE GLYCOL, Thiol-activated cytolysin
Authors:Morton, C.J, Lawrence, S.A, Parker, M.W.
Deposit date:2018-12-05
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin.
Mbio, 10, 2019
3CWL
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BU of 3cwl by Molmil
Crystal structure of alpha-1-antitrypsin, crystal form B
Descriptor: Alpha-1-antitrypsin, CHLORIDE ION
Authors:Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W.
Deposit date:2008-04-22
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
3CWM
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BU of 3cwm by Molmil
Crystal structure of alpha-1-antitrypsin complexed with citrate
Descriptor: Alpha-1-antitrypsin, CITRIC ACID
Authors:Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W.
Deposit date:2008-04-22
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
2QUG
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BU of 2qug by Molmil
Crystal structure of alpha-1-antitrypsin, crystal form A
Descriptor: Alpha-1-antitrypsin
Authors:Hansen, G, Morton, C.J, Pearce, M.C, Feil, S.C, Adams, J.J, Parker, M.W, Bottomley, S.P.
Deposit date:2007-08-05
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
8G33
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BU of 8g33 by Molmil
Activated form of a CDCL long protein
Descriptor: Hemolysin
Authors:Johnstone, B.A, Christie, M.P, Morton, C.J, Parker, M.W.
Deposit date:2023-02-06
Release date:2024-02-07
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Activated form of a CDCL long protein
To Be Published
8G32
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BU of 8g32 by Molmil
Pro-form of a CDCL short from E. anophelis
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Johnstone, B.A, Christie, M.P, Morton, C.J, Parker, M.W.
Deposit date:2023-02-06
Release date:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Pro-form of a CDCL short from E. anophelis
To Be Published
7TBA
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BU of 7tba by Molmil
Pentraxin - ligand complex
Descriptor: C-reactive protein, CALCIUM ION, [3-(dibutylamino)propyl]phosphonic acid
Authors:Shing, K.S.C.T, Morton, C.J, Parker, M.W.
Deposit date:2021-12-21
Release date:2022-10-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein.
Embo Mol Med, 15, 2023
6PRO
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BU of 6pro by Molmil
MnSOD from Geobacillus stearothermophilus
Descriptor: MANGANESE (II) ION, Superoxide dismutase
Authors:Adams, J.J, Morton, C.J, Parker, M.W.
Deposit date:2019-07-10
Release date:2020-05-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.263 Å)
Cite:The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited
Aust.J.Chem., 73, 2020
5IMW
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BU of 5imw by Molmil
Trapped Toxin
Descriptor: Intermedilysin
Authors:Lawrence, S.L, Feil, S.C, Morton, C.J, Parker, M.W.
Deposit date:2016-03-07
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
5IMY
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BU of 5imy by Molmil
Trapped Toxin
Descriptor: CD59 glycoprotein, Vaginolysin
Authors:Lawrence, S.L, Morton, C.J, Parker, M.W.
Deposit date:2016-03-07
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
7LXU
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BU of 7lxu by Molmil
Structure of Plasmodium falciparum 20S proteasome with bound MPI-5
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Metcalfe, R.D, Morton, C.J, Xie, S.C, Liu, B, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2021-03-05
Release date:2021-09-22
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LXV
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BU of 7lxv by Molmil
Structure of human 20S proteasome with bound MPI-5
Descriptor: N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ...
Authors:Metcalfe, R.D, Morton, C.J, Liu, B, Xie, S.C, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2021-03-05
Release date:2021-09-22
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc.Natl.Acad.Sci.USA, 118, 2021
5TLQ
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BU of 5tlq by Molmil
Model structure of the oxidized PaDsbA1 and 3-[(2-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-4-amine complex
Descriptor: 3-[(2-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-4-amine, Thiol:disulfide interchange protein DsbA
Authors:Mohanty, B, Rimmer, K.A, McMahon, R.M, Headey, S.J, Vazirani, M, Shouldice, S.R, Coincon, M, Tay, S, Morton, C.J, Simpson, J.S, Martin, J.L, Scanlon, M.S.
Deposit date:2016-10-11
Release date:2017-04-12
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1.
PLoS ONE, 12, 2017
4P8Q
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BU of 4p8q by Molmil
Crystal Structure of Human Insulin Regulated Aminopeptidase with Alanine in Active Site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucyl-cystinyl aminopeptidase, ...
Authors:Hermans, S.J, Ascher, D.B, Hancock, N.C, Holien, J.K, Michell, B, Morton, C.J, Parker, M.W.
Deposit date:2014-03-31
Release date:2014-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
Protein Sci., 24, 2015
4PJ6
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BU of 4pj6 by Molmil
Crystal Structure of Human Insulin Regulated Aminopeptidase with Lysine in Active Site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LYSINE, ...
Authors:Hermans, S.J, Ascher, D.B, Hancock, N.C, Holien, J.K, Michell, B, Morton, C.J, Parker, M.W.
Deposit date:2014-05-12
Release date:2014-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
Protein Sci., 24, 2015
7ROS
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BU of 7ros by Molmil
Plasmodium falciparum tyrosyl-tRNA synthetase in complex with ML901-Tyr
Descriptor: CHLORIDE ION, MAGNESIUM ION, Tyrosine--tRNA ligase, ...
Authors:Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2021-08-02
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
7ROU
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BU of 7rou by Molmil
Structure of human tyrosyl tRNA synthetase in complex with ML901-Tyr
Descriptor: SULFATE ION, Tyrosine--tRNA ligase, cytoplasmic, ...
Authors:Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2021-08-02
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
7ROR
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BU of 7ror by Molmil
Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP
Descriptor: 5'-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2021-08-02
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022
7ROT
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BU of 7rot by Molmil
Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr
Descriptor: CHLORIDE ION, MAGNESIUM ION, Tyrosine--tRNA ligase, ...
Authors:Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W.
Deposit date:2021-08-02
Release date:2022-06-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science, 376, 2022

 

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