7ROR

Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP

Summary for 7ROR

Entry DOI	10.2210/pdb7ror/pdb
Descriptor	Tyrosine--tRNA ligase, 5'-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine, MALONATE ION, ... (6 entities in total)
Functional Keywords	enzyme, tyrosyl-trna synthetase, malaria, inhibitor, ligase, tyrosine-amp
Biological source	Plasmodium falciparum (isolate 3D7)
Total number of polymer chains	2
Total formula weight	88679.90
Authors	Metcalfe, R.D.,Xie, S.C.,Morton, C.J.,Tilley, L.,Griffin, M.D.W. (deposition date: 2021-08-02, release date: 2022-06-08, Last modification date: 2023-10-18)
Primary citation	Xie, S.C.,Metcalfe, R.D.,Dunn, E.,Morton, C.J.,Huang, S.C.,Puhalovich, T.,Du, Y.,Wittlin, S.,Nie, S.,Luth, M.R.,Ma, L.,Kim, M.S.,Pasaje, C.F.A.,Kumpornsin, K.,Giannangelo, C.,Houghton, F.J.,Churchyard, A.,Famodimu, M.T.,Barry, D.C.,Gillett, D.L.,Dey, S.,Kosasih, C.C.,Newman, W.,Niles, J.C.,Lee, M.C.S.,Baum, J.,Ottilie, S.,Winzeler, E.A.,Creek, D.J.,Williamson, N.,Parker, M.W.,Brand, S.,Langston, S.P.,Dick, L.R.,Griffin, M.D.W.,Gould, A.E.,Tilley, L. Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376:1074-1079, 2022 Cited by PubMed: 35653481 DOI: 10.1126/science.abn0611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation