7LXT

Structure of Plasmodium falciparum 20S proteasome with bound bortezomib

Summary for 7LXT

• Entry DOI: 10.2210/pdb7lxt/pdb
• EMDB information: 23574
• Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome beta-3 subunit, 20S proteasome beta-4 subunit, ... (15 entities in total)
• Functional Keywords: proteasome, plasmodium falciparum, malaria, drug, bortezomib, hydrolase
• Biological source: Plasmodium falciparum (isolate 3D7); More
• Total number of polymer chains: 28
• Total formula weight: 765195.73

Authors

Morton, C.J.,Metcalfe, R.D.,Liu, B.,Xie, S.C.,Hanssen, E.,Leis, A.P.,Tilley, L.,Griffin, M.D.W. (deposition date: 2021-03-05, release date: 2021-09-22, Last modification date: 2022-04-13)

• Primary citation: Xie, S.C.,Metcalfe, R.D.,Mizutani, H.,Puhalovich, T.,Hanssen, E.,Morton, C.J.,Du, Y.,Dogovski, C.,Huang, S.C.,Ciavarri, J.,Hales, P.,Griffin, R.J.,Cohen, L.H.,Chuang, B.C.,Wittlin, S.,Deni, I.,Yeo, T.,Ward, K.E.,Barry, D.C.,Liu, B.,Gillett, D.L.,Crespo-Fernandez, B.F.,Ottilie, S.,Mittal, N.,Churchyard, A.,Ferguson, D.,Aguiar, A.C.C.,Guido, R.V.C.,Baum, J.,Hanson, K.K.,Winzeler, E.A.,Gamo, F.J.,Fidock, D.A.,Baud, D.,Parker, M.W.,Brand, S.,Dick, L.R.,Griffin, M.D.W.,Gould, A.E.,Tilley, L.; Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34548400; DOI: 10.1073/pnas.2107213118

Experimental method

ELECTRON MICROSCOPY (3.4 Å)