1FGQ
 
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1FGR
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1FGO
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1F8N
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1FGT
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1FGM
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1A3C
 | | PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM | | Descriptor: | PYRIMIDINE OPERON REGULATORY PROTEIN PYRR, SAMARIUM (III) ION, SULFATE ION | | Authors: | Tomchick, D.R, Turner, R.J, Switzer, R.W, Smith, J.L. | | Deposit date: | 1998-01-20 | | Release date: | 1998-08-05 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase.
Structure, 6, 1998
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1A4X
 | | PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, HEXAMERIC FORM | | Descriptor: | PYRIMIDINE OPERON REGULATORY PROTEIN PYRR, SULFATE ION | | Authors: | Tomchick, D.R, Turner, R.J, Switzer, R.W, Smith, J.L. | | Deposit date: | 1998-02-08 | | Release date: | 1998-08-05 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase.
Structure, 6, 1998
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4ONR
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8DML
 | | Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt chenodeoxycholate | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHENODEOXYCHOLIC ACID, ... | | Authors: | Tomchick, D.R, Orth, K, Zou, A.J. | | Deposit date: | 2022-07-08 | | Release date: | 2023-06-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus.
J.Biol.Chem., 299, 2023
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6DFT
 | | Trypanosoma brucei deoxyhypusine synthase | | Descriptor: | Deoxyhypusine synthase, Deoxyhypusine synthase regulatory subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Tomchick, D.R, Phillips, M.A, Afanador, G.A. | | Deposit date: | 2018-05-15 | | Release date: | 2018-08-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.
Structure, 26, 2018
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7M7A
 | | Legionella pneumophila MavQ lipid kinase | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Phosphoinositide 3-kinase MavQ | | Authors: | Tomchick, D.R, Tagliabracci, V.S, Hsieh, T.S, Lopez, V.A. | | Deposit date: | 2021-03-27 | | Release date: | 2021-04-28 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Dynamic remodeling of host membranes by self-organizing bacterial effectors.
Science, 372, 2021
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5KEV
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5KEW
 | | Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt taurodeoxycholate | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ... | | Authors: | Tomchick, D.R, Orth, K, Rivera-Cancel, G. | | Deposit date: | 2016-06-10 | | Release date: | 2016-07-20 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.103 Å) | | Cite: | Bile salt receptor complex activates a pathogenic type III secretion system.
Elife, 5, 2016
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5EW4
 | | Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+ | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R. | | Deposit date: | 2015-11-20 | | Release date: | 2016-02-24 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.
Biochemistry, 55, 2016
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5EW7
 | | Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Ba2+ | | Descriptor: | BARIUM ION, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R. | | Deposit date: | 2015-11-20 | | Release date: | 2016-02-24 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.
Biochemistry, 55, 2016
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3BEN
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6E0B
 | | Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1 | | Descriptor: | 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | | Authors: | Tomchick, D.R, Phillips, M.A, Deng, X. | | Deposit date: | 2018-07-06 | | Release date: | 2018-11-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.099 Å) | | Cite: | Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
ACS Infect Dis, 5, 2019
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6EAC
 | | Pseudomonas syringae SelO | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | | Authors: | Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A. | | Deposit date: | 2018-08-02 | | Release date: | 2018-10-03 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.269 Å) | | Cite: | Protein AMPylation by an Evolutionarily Conserved Pseudokinase.
Cell, 175, 2018
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3V5Y
 | | Structure of FBXL5 hemerythrin domain, P2(1) cell | | Descriptor: | F-box/LRR-repeat protein 5, MU-OXO-DIIRON | | Authors: | Tomchick, D.R, Bruick, R.K, Thompson, J.W, Brautigam, C.A. | | Deposit date: | 2011-12-17 | | Release date: | 2012-01-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5).
J.Biol.Chem., 287, 2012
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3V5X
 | | Structure of FBXL5 hemerythrin domain, C2 cell | | Descriptor: | F-box/LRR-repeat protein 5, MU-OXO-DIIRON | | Authors: | Tomchick, D.R, Bruick, R.K, Thompson, J.W, Brautigam, C.A. | | Deposit date: | 2011-12-17 | | Release date: | 2012-01-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5).
J.Biol.Chem., 287, 2012
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3V5Z
 | | Structure of FBXL5 hemerythrin domain, C2 cell, grown anaerobically | | Descriptor: | F-box/LRR-repeat protein 5, MU-OXO-DIIRON | | Authors: | Tomchick, D.R, Bruick, R.K, Thompson, J.W, Brautigam, C.A. | | Deposit date: | 2011-12-17 | | Release date: | 2012-01-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.1847 Å) | | Cite: | Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5).
J.Biol.Chem., 287, 2012
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3L15
 | | Human Tead2 transcriptional factor | | Descriptor: | GLYCEROL, Transcriptional enhancer factor TEF-4 | | Authors: | Tomchick, D.R, Luo, X, Tian, W. | | Deposit date: | 2009-12-10 | | Release date: | 2010-04-07 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and functional analysis of the YAP-binding domain of human TEAD2.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3KY9
 | | Autoinhibited Vav1 | | Descriptor: | Proto-oncogene vav, ZINC ION | | Authors: | Tomchick, D.R, Rosen, M.K, Machius, M, Yu, B. | | Deposit date: | 2009-12-04 | | Release date: | 2010-02-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.731 Å) | | Cite: | Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
Cell(Cambridge,Mass.), 140, 2010
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5JDA
 | | Bacillus cereus CotH kinase plus Mg2+/AMP | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A. | | Deposit date: | 2016-04-15 | | Release date: | 2016-05-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.401 Å) | | Cite: | Phosphorylation of spore coat proteins by a family of atypical protein kinases.
Proc.Natl.Acad.Sci.USA, 113, 2016
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