8IY1
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![BU of 8iy1 by Molmil](/molmil-images/mine/8iy1) | Structure of Acb2 complexed with cAAG | Descriptor: | GUANOSINE-3'-MONOPHOSPHATE, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, p26 | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-04-03 | Release date: | 2024-02-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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8IY0
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![BU of 8iy0 by Molmil](/molmil-images/mine/8iy0) | Structure of Acb2 complexed with cAAA | Descriptor: | [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, p26 | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-04-03 | Release date: | 2024-02-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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8IY2
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![BU of 8iy2 by Molmil](/molmil-images/mine/8iy2) | Structure of Acb2 complexed with 3',3'-cGAMP and cAAA | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-3'-MONOPHOSPHATE, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, ... | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-04-03 | Release date: | 2024-02-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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8J8O
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![BU of 8j8o by Molmil](/molmil-images/mine/8j8o) | Structure of Acb2 complexed with 2',3'-cGAMP | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, cGAMP, ... | Authors: | Cao, X.L, Xiao, Y, Feng, Y. | Deposit date: | 2023-05-02 | Release date: | 2024-02-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides. Mol.Cell, 84, 2024
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4N9B
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![BU of 4n9b by Molmil](/molmil-images/mine/4n9b) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1-methyl-N-(pyridin-3-yl)-1H-pyrazole-5-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhai, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.859 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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4N9E
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![BU of 4n9e by Molmil](/molmil-images/mine/4n9e) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, 1-[(1-benzoylpiperidin-4-yl)methyl]-N-(pyridin-3-yl)-1H-benzimidazole-5-carboxamide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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4N9D
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![BU of 4n9d by Molmil](/molmil-images/mine/4n9d) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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4N9C
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![BU of 4n9c by Molmil](/molmil-images/mine/4n9c) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 5-nitro-1H-benzimidazole, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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5YJ7
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![BU of 5yj7 by Molmil](/molmil-images/mine/5yj7) | Structural insight into the beta-GH1 glucosidase BGLN1 from oleaginous microalgae Nannochloropsis | Descriptor: | CALCIUM ION, GLYCEROL, Glycoside hydrolase | Authors: | Dong, S, Liu, Y.J, Zhou, H.X, Xiao, Y, Xu, J, Cui, Q, Wang, X.Q, Feng, Y.G. | Deposit date: | 2017-10-09 | Release date: | 2018-10-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Structural insight into a GH1 beta-glucosidase from the oleaginous microalga, Nannochloropsis oceanica. Int.J.Biol.Macromol., 170, 2021
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8I3V
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![BU of 8i3v by Molmil](/molmil-images/mine/8i3v) | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom. | Descriptor: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION, Sodium-dependent noradrenaline transporter | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2023-01-18 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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5ZMD
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![BU of 5zmd by Molmil](/molmil-images/mine/5zmd) | Crystal structure of FTO in complex with m6dA modified ssDNA | Descriptor: | Alpha-ketoglutarate-dependent dioxygenase FTO, DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3'), MANGANESE (II) ION, ... | Authors: | Zhang, X, Wei, L.H, Luo, J, Xiao, Y, Liu, J, Zhang, W, Zhang, L, Jia, G.F. | Deposit date: | 2018-04-02 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7K3A
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![BU of 7k3a by Molmil](/molmil-images/mine/7k3a) | Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation B, fusion peptide release | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Gui, M, Gao, J, Xiang, Y. | Deposit date: | 2020-09-10 | Release date: | 2020-11-11 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural intermediates in the low pH-induced transition of influenza hemagglutinin. Plos Pathog., 16, 2020
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7K3B
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![BU of 7k3b by Molmil](/molmil-images/mine/7k3b) | Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation C, central helices splay | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Gui, M, Gao, J, Xiang, Y. | Deposit date: | 2020-09-10 | Release date: | 2020-11-11 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural intermediates in the low pH-induced transition of influenza hemagglutinin. Plos Pathog., 16, 2020
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7K37
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![BU of 7k37 by Molmil](/molmil-images/mine/7k37) | Structure of full-length influenza HA with a head-binding antibody at pH 7.8 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Gui, M, Xiang, Y, Gao, J. | Deposit date: | 2020-09-10 | Release date: | 2020-11-11 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural intermediates in the low pH-induced transition of influenza hemagglutinin. Plos Pathog., 16, 2020
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7K39
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![BU of 7k39 by Molmil](/molmil-images/mine/7k39) | Structure of full-length influenza HA with a head-binding antibody at pH 5.2, conformation A, neutral pH-like | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Gui, M, Gao, J, Xiang, Y. | Deposit date: | 2020-09-10 | Release date: | 2020-11-11 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural intermediates in the low pH-induced transition of influenza hemagglutinin. Plos Pathog., 16, 2020
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2P73
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![BU of 2p73 by Molmil](/molmil-images/mine/2p73) | crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1 | Descriptor: | MANGANESE (II) ION, Putative glycosyltransferase (Mannosyltransferase) involved in glycosylating the PBCV-1 major capsid protein, URIDINE-5'-DIPHOSPHATE | Authors: | Zhang, Y, Xiang, Y, Van Etten, J.L, Rossmann, M.G. | Deposit date: | 2007-03-19 | Release date: | 2007-08-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and function of a chlorella virus-encoded glycosyltransferase. Structure, 15, 2007
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2P72
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![BU of 2p72 by Molmil](/molmil-images/mine/2p72) | crystal structure of a glycosyltransferase involved in the glycosylation of the major capsid of PBCV-1 | Descriptor: | MANGANESE (II) ION, Putative glycosyltransferase (Mannosyltransferase) involved in glycosylating the PBCV-1 major capsid protein, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Zhang, Y, Xiang, Y, Van Etten, J.L, Rossmann, M.G. | Deposit date: | 2007-03-19 | Release date: | 2007-08-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and function of a chlorella virus-encoded glycosyltransferase. Structure, 15, 2007
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4EKX
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![BU of 4ekx by Molmil](/molmil-images/mine/4ekx) | |
4F7K
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![BU of 4f7k by Molmil](/molmil-images/mine/4f7k) | |
4EEE
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![BU of 4eee by Molmil](/molmil-images/mine/4eee) | |
5WRG
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![BU of 5wrg by Molmil](/molmil-images/mine/5wrg) | SARS-CoV spike glycoprotein | Descriptor: | Spike glycoprotein | Authors: | Gui, M, Song, W, Xiang, Y, Wang, X. | Deposit date: | 2016-12-01 | Release date: | 2017-01-11 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Res., 27, 2017
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5XLR
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![BU of 5xlr by Molmil](/molmil-images/mine/5xlr) | Structure of SARS-CoV spike glycoprotein | Descriptor: | Spike glycoprotein | Authors: | Gui, M, Song, W, Xiang, Y, Wang, X. | Deposit date: | 2017-05-11 | Release date: | 2017-06-07 | Last modified: | 2019-10-09 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Res., 27, 2017
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6LUM
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![BU of 6lum by Molmil](/molmil-images/mine/6lum) | Structure of Mycobacterium smegmatis succinate dehydrogenase 2 | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ... | Authors: | Gao, Y, Gong, H, Zhou, X, Xiao, Y, Wang, W, Ji, W, Wang, Q, Rao, Z. | Deposit date: | 2020-01-29 | Release date: | 2020-05-27 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF. Nat Commun, 11, 2020
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3TXS
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![BU of 3txs by Molmil](/molmil-images/mine/3txs) | Crystal Structure of phage 44RR small terminase gp16 | Descriptor: | Terminase DNA packaging enzyme small subunit | Authors: | Sun, S, Xiang, Y, Rossmann, M.G. | Deposit date: | 2011-09-23 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structure and function of the small terminase component of the DNA packaging machine in T4-like bacteriophages. Proc.Natl.Acad.Sci.USA, 109, 2012
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3TXQ
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![BU of 3txq by Molmil](/molmil-images/mine/3txq) | |