7NTU
 
 | | X-ray structure of the complex between human alpha thrombin and two duplex/quadruplex aptamers: NU172 and HD22_27mer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, HD22_27mer, ... | | Authors: | Troisi, R, Santamaria, A, Sica, F. | | Deposit date: | 2021-03-10 | | Release date: | 2021-04-28 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural and functional analysis of the simultaneous binding of two duplex/quadruplex aptamers to human alpha-thrombin.
Int.J.Biol.Macromol., 181, 2021
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8RD7
 | | HUWE1 WWE domain in complex with ADP-ribose | | Descriptor: | ACETATE ION, CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1, ... | | Authors: | Muenzker, L, Zak, K.M, Boettcher, J. | | Deposit date: | 2023-12-07 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
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8R5N
 | | DTX1 WWE domain in complex with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, E3 ubiquitin-protein ligase DTX1 | | Authors: | Muenzker, L, Zak, K.M, Boettcher, J. | | Deposit date: | 2023-11-17 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.812 Å) | | Cite: | A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
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8R6B
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8R7O
 | | HUWE1 WWE domain in complex with 2'F-ATP | | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1, SODIUM ION, ... | | Authors: | Muenzker, L, Boettcher, J. | | Deposit date: | 2023-11-27 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
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8RD1
 | | HUWE1 WWE domain in complex with compound 4 | | Descriptor: | 2-(2-hydroxy-2-oxoethyl)-1,3-bis(oxidanylidene)isoindole-5-carboxylic acid, CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1 | | Authors: | Muenzker, L, Zak, K.M, Boettcher, J. | | Deposit date: | 2023-12-07 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.896 Å) | | Cite: | A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
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8R6A
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8RD0
 | | HUWE1 WWE domain in complex with compound 3 | | Descriptor: | (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid, CHLORIDE ION, E3 ubiquitin-protein ligase HUWE1 | | Authors: | Muenzker, L, Boettcher, J. | | Deposit date: | 2023-12-07 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.765 Å) | | Cite: | A ligand discovery toolbox for the WWE domain family of human E3 ligases.
Commun Biol, 7, 2024
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6K6L
 | | YGL082W-catalytic domain | | Descriptor: | pseudo deubiquitinase | | Authors: | Lu, L.N, Wang, F. | | Deposit date: | 2019-06-03 | | Release date: | 2019-07-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop
Sci China Chem, 2019
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4KL7
 | | Crystal structure of the catalytic domain of RpfB from Mycobacterium tuberculosis | | Descriptor: | Resuscitation-promoting factor RpfB, SULFATE ION | | Authors: | Squeglia, F, Romano, M, Ruggiero, A, Berisio, R. | | Deposit date: | 2013-05-07 | | Release date: | 2013-06-26 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Carbohydrate Recognition by RpfB from Mycobacterium tuberculosis Unveiled by Crystallographic and Molecular Dynamics Analyses.
Biophys.J., 104, 2013
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4KPM
 | | Crystal structure of the catalytic domain of RpfB from Mycobacterium tuberculosis in complex with triNAG | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, Resuscitation-promoting factor RpfB, ... | | Authors: | Squeglia, F, Ruggiero, A, Berisio, R. | | Deposit date: | 2013-05-14 | | Release date: | 2013-06-26 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Carbohydrate Recognition by RpfB from Mycobacterium tuberculosis Unveiled by Crystallographic and Molecular Dynamics Analyses.
Biophys.J., 104, 2013
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2RHI
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2RHY
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2RHX
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2RI3
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2RHZ
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8HR1
 | | Cryo-EM structure of SSX1 bound to the unmodified nucleosome at a resolution of 3.02 angstrom | | Descriptor: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | Authors: | Zebin, T, Ai, H.S, Ziyu, X, Man, P, Liu, L. | | Deposit date: | 2022-12-14 | | Release date: | 2023-09-13 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes.
Nat.Struct.Mol.Biol., 31, 2024
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8HQY
 | | Cryo-EM structure of SSX1 bound to the H2AK119Ub nucleosome at a resolution of 3.05 angstrom | | Descriptor: | DNA (136-MER), DNA (137-MER), Histone H2A type 1-B/E, ... | | Authors: | Zebin, T, Ai, H.S, Ziyu, X, GuoChao, C, Man, P, Liu, L. | | Deposit date: | 2022-12-14 | | Release date: | 2023-09-27 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes.
Nat.Struct.Mol.Biol., 31, 2024
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8AJ7
 | | Kunitz domain of Amblyomin-X | | Descriptor: | 1,2-ETHANEDIOL, Kunitz domain of Amblyomin-X | | Authors: | Ciccone, L, Servent, D, Stura, E.A. | | Deposit date: | 2022-07-27 | | Release date: | 2023-02-15 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity.
Front Mol Biosci, 10, 2023
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3BCP
 | | Crystal Structure of The Swapped non covalent form of P19A/L28Q/N67D BS-RNase | | Descriptor: | Seminal ribonuclease | | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | | Deposit date: | 2007-11-13 | | Release date: | 2008-02-12 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme
J.Mol.Biol., 376, 2008
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3BCM
 | | Crystal Structure of The Unswapped Form of P19A/L28Q/N67D BS-RNase | | Descriptor: | PHOSPHATE ION, Seminal ribonuclease | | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | | Deposit date: | 2007-11-13 | | Release date: | 2008-02-12 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme
J.Mol.Biol., 376, 2008
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3BCO
 | | Crystal Structure of The Swapped FOrm of P19A/L28Q/N67D BS-RNase | | Descriptor: | Seminal ribonuclease | | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | | Deposit date: | 2007-11-13 | | Release date: | 2008-02-12 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme
J.Mol.Biol., 376, 2008
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1N3Z
 | | Crystal structure of the [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] monomeric derivative of the bovine seminal ribonuclease in the liganded state | | Descriptor: | 3'-URIDINEMONOPHOSPHATE, ADENOSINE, Ribonuclease, ... | | Authors: | Sica, F, Di Fiore, A, Zagari, A, Mazzarella, L. | | Deposit date: | 2002-10-30 | | Release date: | 2003-08-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative
Proteins, 52, 2003
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3P7O
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3P7L
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