8RD0

HUWE1 WWE domain in complex with compound 3

Summary for 8RD0

Entry DOI	10.2210/pdb8rd0/pdb
Descriptor	E3 ubiquitin-protein ligase HUWE1, CHLORIDE ION, (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid, ... (4 entities in total)
Functional Keywords	wwe domain, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	42701.30
Authors	Muenzker, L.,Boettcher, J. (deposition date: 2023-12-07, release date: 2024-07-31)
Primary citation	Munzker, L.,Kimani, S.W.,Fowkes, M.M.,Dong, A.,Zheng, H.,Li, Y.,Dasovich, M.,Zak, K.M.,Leung, A.K.L.,Elkins, J.M.,Kessler, D.,Arrowsmith, C.H.,Halabelian, L.,Bottcher, J. A ligand discovery toolbox for the WWE domain family of human E3 ligases Commun Biol, 7:901-, 2024 Cited by DOI: 10.1038/s42003-024-06584-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.765 Å)

Structure validation