5H17
| EED in complex with PRC2 allosteric inhibitor EED210 | Descriptor: | (3R,4aS,10aS)-6-methoxy-3-[(3-methoxyphenyl)methyl]-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | Authors: | Zhao, K, Zhao, M, Luo, X, Zhang, H. | Deposit date: | 2016-10-08 | Release date: | 2017-01-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE, 12, 2017
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2F4O
| The Mouse PNGase-HR23 Complex Reveals a Complete Remodulation of the Protein-Protein Interface Compared to its Yeast Orthologs | Descriptor: | CHLORIDE ION, PHQ-VAL-ALA-ASP-CF0, XP-C repair complementing complex 58 kDa protein, ... | Authors: | Zhao, G, Zhou, X, Wang, L, Kisker, C, Lennarz, W.J, Schindelin, H. | Deposit date: | 2005-11-23 | Release date: | 2006-03-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways. J.Biol.Chem., 281, 2006
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4YP8
| Irak4-inhibitor co-structure | Descriptor: | Interleukin-1 receptor-associated kinase 4, N-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Authors: | Fischmann, T.O. | Deposit date: | 2015-03-12 | Release date: | 2015-05-20 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.641 Å) | Cite: | Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation. Acs Med.Chem.Lett., 6, 2015
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2F4M
| The Mouse PNGase-HR23 Complex Reveals a Complete Remodulation of the Protein-Protein Interface Compared to its Yeast Orthologs | Descriptor: | CHLORIDE ION, UV excision repair protein RAD23 homolog B, ZINC ION, ... | Authors: | Zhao, G, Zhou, X, Wang, L, Kisker, C, Lennarz, W.J, Schindelin, H. | Deposit date: | 2005-11-23 | Release date: | 2006-03-07 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways. J.Biol.Chem., 281, 2006
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6AH3
| Cryo-EM structure of yeast Ribonuclease P with pre-tRNA substrate | Descriptor: | MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, ... | Authors: | Lan, P, Tan, M, Wu, J, Lei, M. | Deposit date: | 2018-08-16 | Release date: | 2018-10-17 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structural insight into precursor tRNA processing by yeast ribonuclease P. Science, 362, 2018
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6A71
| Crystal Structure of Human ATP7B and TM Complex | Descriptor: | ATP7B protein, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Chen, W.B. | Deposit date: | 2018-06-30 | Release date: | 2019-04-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein. Nat Commun, 10, 2019
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3ESW
| Complex of yeast PNGase with GlcNAc2-IAc. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, UV excision repair protein RAD23, ... | Authors: | Zhao, G, Zhou, X, Lennarz, W.J, Schindelin, H. | Deposit date: | 2008-10-06 | Release date: | 2008-11-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural and mutational studies on the importance of oligosaccharide binding for the activity of yeast PNGase. Glycobiology, 19, 2009
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6AGB
| Cryo-EM structure of yeast Ribonuclease P | Descriptor: | RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, Ribonuclease P protein subunit RPR2, ... | Authors: | Lan, P, Tan, M, Wu, J, Lei, M. | Deposit date: | 2018-08-10 | Release date: | 2018-10-17 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structural insight into precursor tRNA processing by yeast ribonuclease P. Science, 362, 2018
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6AY2
| Structure of CathB with covalently linked Compound 28 | Descriptor: | Cathepsin B, N~1~-[(2S)-1-amino-5-(carbamoylamino)pentan-2-yl]-N'~1~-[(1R)-1-(thiophen-3-yl)ethyl]cyclobutane-1,1-dicarboxamide | Authors: | Kiefer, J.R, Steinbacher, S. | Deposit date: | 2017-09-07 | Release date: | 2017-12-27 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. J. Med. Chem., 61, 2018
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4Z9P
| Crystal structure of Ebola virus nucleoprotein core domain at 1.8A resolution | Descriptor: | Nucleoprotein | Authors: | Guo, Y, Dong, S.S, Yang, P, Li, G.B, Liu, B.C, Yang, C, Rao, Z.H. | Deposit date: | 2015-04-11 | Release date: | 2015-05-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.792 Å) | Cite: | Insight into the Ebola virus nucleocapsid assembly mechanism: crystal structure of Ebola virus nucleoprotein core domain at 1.8 A resolution. Protein Cell, 6, 2015
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7V2Y
| cryo-EM structure of yeast THO complex with Sub2 | Descriptor: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ... | Authors: | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2021-08-10 | Release date: | 2022-07-27 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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7V2W
| protomer structure from the dimer of yeast THO complex | Descriptor: | Protein TEX1, THO complex subunit 2, THO complex subunit HPR1, ... | Authors: | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2021-08-10 | Release date: | 2022-07-27 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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3GAE
| Crystal Structure of PUL | Descriptor: | CHLORIDE ION, GLYCEROL, Protein DOA1 | Authors: | Zhao, G, Schindelin, H, Lennarz, W.J. | Deposit date: | 2009-02-17 | Release date: | 2009-12-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation Proc.Natl.Acad.Sci.USA, 106, 2009
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7UP2
| NDM1-inhibitor co-structure | Descriptor: | (2M)-4'-methyl-2-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION | Authors: | Scapin, G, Fischmann, T.O. | Deposit date: | 2022-04-14 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates. J.Med.Chem., 65, 2022
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7UP1
| NDM1-inhibitor co-structure | Descriptor: | (2M)-4'-methyl-2-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, CADMIUM ION, Metallo beta-lactamase, ... | Authors: | Scapin, G, Fischmann, T.O. | Deposit date: | 2022-04-14 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.11 Å) | Cite: | Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates. J.Med.Chem., 65, 2022
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7UP3
| NDM1-inhibitor co-structure | Descriptor: | (3P)-4-[4-(hydroxymethyl)phenyl]-3-(2H-tetrazol-5-yl)pyridine-2-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CADMIUM ION, ... | Authors: | Scapin, G, Fischmann, T.O. | Deposit date: | 2022-04-14 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates. J.Med.Chem., 65, 2022
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7UOX
| NDM1-inhibitor co-structure | Descriptor: | (2M)-4'-(hydroxymethyl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-ol, ACETATE ION, CADMIUM ION, ... | Authors: | Scapin, G, Fischmann, T.O. | Deposit date: | 2022-04-14 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates. J.Med.Chem., 65, 2022
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7UOY
| NDM1-inhibitor co-structure | Descriptor: | (6P)-4-amino-6-(2H-tetrazol-5-yl)benzene-1,3-disulfonamide, CADMIUM ION, Metallo beta-lactamase, ... | Authors: | Scapin, G, Fischmann, T.O. | Deposit date: | 2022-04-14 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates. J.Med.Chem., 65, 2022
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1X79
| Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5 | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ADP-ribosylation factor binding protein GGA1, Rab GTPase binding effector protein 1, ... | Authors: | Zhu, G, Zhang, X.C. | Deposit date: | 2004-08-13 | Release date: | 2004-10-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5. EMBO J., 23, 2004
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7V99
| catalytic core of human telomerase holoenzyme | Descriptor: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | Authors: | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2021-08-24 | Release date: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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7V9A
| biogenesis module of human telomerase holoenzyme | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | Authors: | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | Deposit date: | 2021-08-24 | Release date: | 2022-03-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.94 Å) | Cite: | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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5ZAZ
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8K4Q
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8J6T
| Cryo-EM structure of the double CAF-1 bound right-handed Di-tetrasome | Descriptor: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | Authors: | Liu, C.P, Yu, Z.Y, Xu, R.M. | Deposit date: | 2023-04-26 | Release date: | 2023-08-16 | Last modified: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
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8J6S
| Cryo-EM structure of the single CAF-1 bound right-handed Di-tetrasome | Descriptor: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | Authors: | Liu, C.P, Yu, Z.Y, Xu, R.M. | Deposit date: | 2023-04-26 | Release date: | 2023-08-16 | Last modified: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
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