6AY2
Structure of CathB with covalently linked Compound 28
Summary for 6AY2
Entry DOI | 10.2210/pdb6ay2/pdb |
Descriptor | Cathepsin B, N~1~-[(2S)-1-amino-5-(carbamoylamino)pentan-2-yl]-N'~1~-[(1R)-1-(thiophen-3-yl)ethyl]cyclobutane-1,1-dicarboxamide (3 entities in total) |
Functional Keywords | protease, covalent, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Lysosome : P07858 |
Total number of polymer chains | 2 |
Total formula weight | 56735.35 |
Authors | Kiefer, J.R.,Steinbacher, S. (deposition date: 2017-09-07, release date: 2017-12-27, Last modification date: 2018-02-21) |
Primary citation | Wei, B.,Gunzner-Toste, J.,Yao, H.,Wang, T.,Wang, J.,Xu, Z.,Chen, J.,Wai, J.,Nonomiya, J.,Tsai, S.P.,Chuh, J.,Kozak, K.R.,Liu, Y.,Yu, S.F.,Lau, J.,Li, G.,Phillips, G.D.,Leipold, D.,Kamath, A.,Su, D.,Xu, K.,Eigenbrot, C.,Steinbacher, S.,Ohri, R.,Raab, H.,Staben, L.R.,Zhao, G.,Flygare, J.A.,Pillow, T.H.,Verma, V.,Masterson, L.A.,Howard, P.W.,Safina, B. Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. J. Med. Chem., 61:989-1000, 2018 Cited by PubMed: 29227683DOI: 10.1021/acs.jmedchem.7b01430 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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