6B20
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![BU of 6b20 by Molmil](/molmil-images/mine/6b20) | Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator | Descriptor: | CHLORIDE ION, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... | Authors: | Gulati, S, Kiser, P.D, Palczewski, K. | Deposit date: | 2017-09-19 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun, 9, 2018
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3STB
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![BU of 3stb by Molmil](/molmil-images/mine/3stb) | A complex of two editosome proteins and two nanobodies | Descriptor: | MP18 RNA editing complex protein, RNA-editing complex protein MP42, single domain antibody VHH | Authors: | Park, Y.-J, Hol, W. | Deposit date: | 2011-07-09 | Release date: | 2011-11-02 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody. Nucleic Acids Res., 40, 2012
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3K80
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![BU of 3k80 by Molmil](/molmil-images/mine/3k80) | Structure of essential protein from Trypanosoma brucei | Descriptor: | Antibody, MP18 RNA editing complex protein | Authors: | Wu, M. | Deposit date: | 2009-10-13 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. J.Struct.Biol., 174, 2011
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3K81
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![BU of 3k81 by Molmil](/molmil-images/mine/3k81) | |
3K7U
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![BU of 3k7u by Molmil](/molmil-images/mine/3k7u) | Structure of essential protein from Trypanosoma brucei | Descriptor: | Antibody, MP18 RNA editing complex protein | Authors: | Wu, M. | Deposit date: | 2009-10-13 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. J.Struct.Biol., 174, 2011
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6HEQ
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![BU of 6heq by Molmil](/molmil-images/mine/6heq) | Prion nanobody 484 | Descriptor: | Prion nanobody 484 | Authors: | Soror, S.H, Abskharon, R.N, Wohlkonig, A. | Deposit date: | 2018-08-20 | Release date: | 2019-12-04 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. Plos Pathog., 15, 2019
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5DA0
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![BU of 5da0 by Molmil](/molmil-images/mine/5da0) | Structure of the the SLC26 transporter SLC26Dg in complex with a nanobody | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, Nanobody, Sulphate transporter | Authors: | Dutzler, R, Geertsma, E.R, Chang, Y, Shaik, F.R. | Deposit date: | 2015-08-19 | Release date: | 2015-09-09 | Last modified: | 2015-10-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family. Nat.Struct.Mol.Biol., 22, 2015
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5M94
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![BU of 5m94 by Molmil](/molmil-images/mine/5m94) | |
5VAN
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![BU of 5van by Molmil](/molmil-images/mine/5van) | Crystal Structure of Beta-Klotho | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
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5VAK
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![BU of 5vak by Molmil](/molmil-images/mine/5vak) | Crystal Structure of Beta-Klotho, Domain 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
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5VAQ
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![BU of 5vaq by Molmil](/molmil-images/mine/5vaq) | Crystal Structure of Beta-Klotho in Complex with FGF21CT | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, Fibroblast growth factor 21, ... | Authors: | Lee, S, Schlessinger, J. | Deposit date: | 2017-03-27 | Release date: | 2018-01-31 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (2.606 Å) | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature, 553, 2018
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6RR7
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![BU of 6rr7 by Molmil](/molmil-images/mine/6rr7) | Influenza A virus (A/NT/60/1968) polymerase Heterotrimer bound to 3'5' vRNA promoter and capped RNA primer | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D(*(M7G))-R(P*AP*AP*UP*CP*U)-3'), ... | Authors: | Carrique, L, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | Deposit date: | 2019-05-17 | Release date: | 2019-09-04 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structures of influenza A virus RNA polymerase offer insight into viral genome replication. Nature, 573, 2019
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5DFZ
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![BU of 5dfz by Molmil](/molmil-images/mine/5dfz) | Structure of Vps34 complex II from S. cerevisiae. | Descriptor: | Nanobody binding S. cerevisiae Vps34, Phosphatidylinositol 3-kinase VPS34, Putative N-terminal domain of S. cerevisiae Vps30, ... | Authors: | Rostislavleva, K, Soler, N, Ohashi, Y, Zhang, L, Williams, R.L. | Deposit date: | 2015-08-27 | Release date: | 2015-10-07 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Science, 350, 2015
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8FD1
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![BU of 8fd1 by Molmil](/molmil-images/mine/8fd1) | Crystal structure of photoactivated rhodopsin in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | Authors: | Salom, D, Palczewski, K, Kiser, P.D. | Deposit date: | 2022-12-01 | Release date: | 2023-08-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.25 Å) | Cite: | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
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8FD0
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![BU of 8fd0 by Molmil](/molmil-images/mine/8fd0) | Crystal structure of bovine rod opsin in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | Authors: | Salom, D, Palczewski, K, Kiser, P.D. | Deposit date: | 2022-12-01 | Release date: | 2023-08-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.71 Å) | Cite: | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
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8FCZ
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![BU of 8fcz by Molmil](/molmil-images/mine/8fcz) | Crystal structure of ground-state rhodopsin in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | Authors: | Salom, D, Palczewski, K, Kiser, P.D. | Deposit date: | 2022-12-01 | Release date: | 2023-08-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun, 14, 2023
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8FQ7
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![BU of 8fq7 by Molmil](/molmil-images/mine/8fq7) | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | Descriptor: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | Authors: | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | Deposit date: | 2023-01-05 | Release date: | 2023-10-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
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7APJ
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![BU of 7apj by Molmil](/molmil-images/mine/7apj) | Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation | Descriptor: | NB41, RAC-alpha serine/threonine-protein kinase,Non-specific serine/threonine protein kinase,RAC-alpha serine/threonine-protein kinase | Authors: | Truebestein, L, Hornegger, H, Leonard, T.A. | Deposit date: | 2020-10-16 | Release date: | 2021-08-25 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure of autoinhibited Akt1 reveals mechanism of PIP 3 -mediated activation. Proc.Natl.Acad.Sci.USA, 118, 2021
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5DA4
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![BU of 5da4 by Molmil](/molmil-images/mine/5da4) | |
5G5R
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![BU of 5g5r by Molmil](/molmil-images/mine/5g5r) | |
5G5X
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![BU of 5g5x by Molmil](/molmil-images/mine/5g5x) | |
7SPA
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![BU of 7spa by Molmil](/molmil-images/mine/7spa) | Chlorella virus Hyaluronan Synthase in the GlcNAc-primed, channel-open state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | Deposit date: | 2021-11-02 | Release date: | 2022-04-06 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase. Nature, 604, 2022
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7SP9
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![BU of 7sp9 by Molmil](/molmil-images/mine/7sp9) | Chlorella virus Hyaluronan Synthase in the GlcNAc-primed channel-closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | Deposit date: | 2021-11-02 | Release date: | 2022-04-06 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase. Nature, 604, 2022
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7SP6
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![BU of 7sp6 by Molmil](/molmil-images/mine/7sp6) | Chlorella virus hyaluronan synthase | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | Deposit date: | 2021-11-02 | Release date: | 2022-04-06 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase. Nature, 604, 2022
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7SP8
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![BU of 7sp8 by Molmil](/molmil-images/mine/7sp8) | Chlorella virus Hyaluronan Synthase bound to UDP-GlcNAc | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | Deposit date: | 2021-11-02 | Release date: | 2022-04-06 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase. Nature, 604, 2022
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