2QNV
| Crystal Structure of the Pregnane X Receptor bound to Colupulone | Descriptor: | 3,5-dihydroxy-4,6,6-tris(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,4-dien-1-one, Orphan nuclear receptor PXR | Authors: | Teotico, D.G, Bischof, J, Redinbo, M.R. | Deposit date: | 2007-07-19 | Release date: | 2008-07-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the Pregnane X Receptor bound to Colupulone TO BE PUBLISHED
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6D7J
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6AZ6
| Streptococcus agalactiae GntR | Descriptor: | GntR family transcriptional regulator | Authors: | Pellock, S.J, Redinbo, M.R. | Deposit date: | 2017-09-10 | Release date: | 2017-12-20 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (1.909 Å) | Cite: | Structural basis for the regulation of beta-glucuronidase expression by human gut Enterobacteriaceae. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6AZH
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6BAQ
| Mus musculus BPIFA1 | Descriptor: | BPI fold-containing family A member 1, CHLORIDE ION, GLYCEROL, ... | Authors: | Little, M.S, Redinbo, M.R. | Deposit date: | 2017-10-15 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.50261 Å) | Cite: | Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6BJQ
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6D1N
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6BJW
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6BO6
| Eubacterium eligens beta-glucuronidase bound to UNC4917 glucuronic acid conjugate | Descriptor: | 4-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-2,7-bis(methylamino)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, Glycoside Hydrolase Family 2 candidate b-glucuronidase | Authors: | Pellock, S.J, Walton, W.G, Redinbo, M.R. | Deposit date: | 2017-11-18 | Release date: | 2018-07-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Gut Microbial beta-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS Cent Sci, 4, 2018
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6CXS
| Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine | Descriptor: | 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine, Beta-glucuronidase, Maltose/maltodextrin-binding periplasmic protein | Authors: | Wallace, B.D, Redinbo, M.R. | Deposit date: | 2018-04-04 | Release date: | 2019-04-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Targeted inhibition of gut bacterial beta-glucuronidase activity enhances anticancer drug efficacy. Proc.Natl.Acad.Sci.USA, 2020
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6D41
| Bacteriodes uniformis beta-glucuronidase 1 bound to D-glucaro-1,5-lactone | Descriptor: | (2S,3S,4S,5R)-3,4,5-trihydroxy-6-oxo-oxane-2-carboxylic acid, Beta-galactosidase/beta-glucuronidase, CHLORIDE ION, ... | Authors: | Walton, W.G, Pellock, S.J, Redinbo, M.R. | Deposit date: | 2018-04-17 | Release date: | 2018-10-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
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6D50
| Bacteroides uniforms beta-glucuronidase 2 bound to D-glucaro-1,5-lactone | Descriptor: | (2S,3S,4S,5R)-3,4,5-trihydroxy-6-oxo-oxane-2-carboxylic acid, CALCIUM ION, Glycosyl hydrolases family 2, ... | Authors: | Walton, W.G, Pellock, S.J, Redinbo, M.R. | Deposit date: | 2018-04-19 | Release date: | 2018-10-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
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6D1P
| Apo structure of Bacteroides uniformis beta-glucuronidase 3 | Descriptor: | GLYCEROL, Glycosyl hydrolases family 2, sugar binding domain protein, ... | Authors: | Walton, W.G, Pellock, S.J, Redinbo, M.R. | Deposit date: | 2018-04-12 | Release date: | 2018-10-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
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6D89
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7L7W
| Crystal structure of Arabidopsis NRG1.1 CC-R domain K94E/K96E mutant | Descriptor: | NICKEL (II) ION, Probable disease resistance protein At5g66900 | Authors: | Walton, W.G, Wan, L, Lietzan, A.D, Redinbo, M.R, Dangl, J.L. | Deposit date: | 2020-12-30 | Release date: | 2021-06-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Plant "helper" immune receptors are Ca 2+ -permeable nonselective cation channels. Science, 373, 2021
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7L7V
| Crystal structure of Arabidopsis NRG1.1 CC-R domain K94E/K96E/R99E/K100E/R103E/K106E/K110E mutant | Descriptor: | Probable disease resistance protein At5g66900 | Authors: | Walton, W.G, Wan, L, Lietzan, A.D, Redinbo, M.R, Dangl, J.L. | Deposit date: | 2020-12-30 | Release date: | 2021-06-16 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Plant "helper" immune receptors are Ca 2+ -permeable nonselective cation channels. Science, 373, 2021
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6D4O
| Eubacterium eligens beta-glucuronidase bound to an amoxapine-glucuronide conjugate | Descriptor: | (5aR,9aR)-2-chloro-11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5a,6,9,9a-tetrahydrodibenzo[b,f][1,4]oxazepine, Beta-glucuronidase, CHLORIDE ION, ... | Authors: | Pellock, S.J, Walton, W.G, Redinbo, M.R. | Deposit date: | 2018-04-18 | Release date: | 2018-07-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Gut Microbial beta-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS Cent Sci, 4, 2018
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7KFO
| Crystal structure of the MarR family transcriptional regulator from Variovorax paradoxus bound to Indole 3 acetic acid | Descriptor: | 1H-INDOL-3-YLACETIC ACID, SULFATE ION, Transcriptional regulator, ... | Authors: | Walton, W.G, Redinbo, M.R, Dangl, J.L. | Deposit date: | 2020-10-14 | Release date: | 2021-11-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome. Nat Microbiol, 7, 2022
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7KGZ
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7KFQ
| Crystal structure of the MarR family transcriptional regulator from Variovorax paradoxus bound to 1H-Indole-3-Carboxylic Acid | Descriptor: | 1H-INDOLE-3-CARBOXYLIC ACID, SULFATE ION, Transcriptional regulator, ... | Authors: | Walton, W.G, Redinbo, M.R, Dangl, J.L. | Deposit date: | 2020-10-14 | Release date: | 2021-11-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome. Nat Microbiol, 7, 2022
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7KFS
| Crystal structure of the MarR family transcriptional regulator from Variovorax paradoxus bound to Benzoic Acid | Descriptor: | BENZOIC ACID, SULFATE ION, Transcriptional regulator, ... | Authors: | Walton, W.G, Redinbo, M.R, Dangl, J.L. | Deposit date: | 2020-10-14 | Release date: | 2021-11-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome. Nat Microbiol, 7, 2022
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7KGY
| Beta-glucuronidase from Faecalibacterium prausnitzii bound to the inhibitor UNC10201652-glucuronide | Descriptor: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, Beta-glucuronidase, GLYCEROL | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2020-10-19 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun, 13, 2022
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7KUA
| Crystal structure of the MarR family transcriptional regulator from Pseudomonas putida bound to Indole 3 acetic acid | Descriptor: | 1H-INDOL-3-YLACETIC ACID, Transcriptional regulator, MarR family | Authors: | Walton, W.G, Lietzan, A.D, Redinbo, M.R, Dangl, J.L. | Deposit date: | 2020-11-24 | Release date: | 2021-12-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome. Nat Microbiol, 7, 2022
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7KJL
| Crystal structure of the MarR family transcriptional regulator from Variovorax paradoxus bound to Salicylic acid | Descriptor: | 2-HYDROXYBENZOIC ACID, SULFATE ION, Transcriptional regulator, ... | Authors: | Walton, W.G, Redinbo, M.R, Dangl, J.L. | Deposit date: | 2020-10-26 | Release date: | 2021-12-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome. Nat Microbiol, 7, 2022
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7KH3
| Crystal structure of the MarR family transcriptional regulator from Variovorax paradoxus bound to Indole 3 propionic acid | Descriptor: | INDOLYLPROPIONIC ACID, SULFATE ION, Transcriptional regulator, ... | Authors: | Walton, W.G, Redinbo, M.R, Dangl, J.L. | Deposit date: | 2020-10-19 | Release date: | 2021-12-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome. Nat Microbiol, 7, 2022
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