4ZX3
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![BU of 4zx3 by Molmil](/molmil-images/mine/4zx3) | |
4ZY1
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![BU of 4zy1 by Molmil](/molmil-images/mine/4zy1) | |
5CDX
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4Z09
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![BU of 4z09 by Molmil](/molmil-images/mine/4z09) | Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp [Thr2040Ala] peptide | Descriptor: | Apical membrane antigen 1, GLYCEROL, Rhoptry neck protein 2 | Authors: | Wang, G, McGowan, S, Norton, R.S, Scanlon, M.J. | Deposit date: | 2015-03-26 | Release date: | 2016-08-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction. J.Mol.Biol., 428, 2016
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4Z0D
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![BU of 4z0d by Molmil](/molmil-images/mine/4z0d) | Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp [Phe2038Trp] peptide | Descriptor: | Apical membrane antigen 1, Rhoptry neck protein 2 | Authors: | Wang, G, McGowan, S, Norton, R.S, Scanlon, M.J. | Deposit date: | 2015-03-26 | Release date: | 2016-08-03 | Last modified: | 2020-01-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction. J.Mol.Biol., 428, 2016
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4Z0E
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![BU of 4z0e by Molmil](/molmil-images/mine/4z0e) | Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp [Phe2038TRN] peptide | Descriptor: | Apical membrane antigen 1, Rhoptry neck protein 2 | Authors: | Wang, G, McGowan, S, Norton, R.S, Scanlon, M.J. | Deposit date: | 2015-03-26 | Release date: | 2016-08-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction. J.Mol.Biol., 428, 2016
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4Z0F
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![BU of 4z0f by Molmil](/molmil-images/mine/4z0f) | Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp [Phe2038(6CW)] peptide | Descriptor: | Apical membrane antigen 1, Rhoptry neck protein 2 | Authors: | Wang, G, McGowan, S, Norton, R.S, Scanlon, M.J. | Deposit date: | 2015-03-26 | Release date: | 2016-08-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction. J.Mol.Biol., 428, 2016
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4ZQT
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![BU of 4zqt by Molmil](/molmil-images/mine/4zqt) | Crystal structure of PfA-M1 with virtual ligand inhibitor | Descriptor: | (2R)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, GLYCEROL, M1 family aminopeptidase, ... | Authors: | Ruggeri, C, Drinkwater, N, McGowan, S. | Deposit date: | 2015-05-11 | Release date: | 2015-10-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.981 Å) | Cite: | Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening. Plos One, 10, 2015
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5CBM
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![BU of 5cbm by Molmil](/molmil-images/mine/5cbm) | Crystal structure of PfA-M17 with virtual ligand inhibitor | Descriptor: | (2S)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, CARBONATE ION, GLYCEROL, ... | Authors: | Ruggeri, C, Drinkwater, N, McGowan, S. | Deposit date: | 2015-07-01 | Release date: | 2015-10-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening. Plos One, 10, 2015
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8SLO
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![BU of 8slo by Molmil](/molmil-images/mine/8slo) | Plasmodium falciparum M1 aminopeptidase bound to selective inhibitor MIPS2673 | Descriptor: | 2-hydroxy-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-2-methylpropanamide, GLYCEROL, M1 family aminopeptidase, ... | Authors: | McGowan, S.M, Drinkwater, N. | Deposit date: | 2023-04-24 | Release date: | 2024-04-03 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. Elife, 13, 2024
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3H7T
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3H7O
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![BU of 3h7o by Molmil](/molmil-images/mine/3h7o) | |
4U6W
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![BU of 4u6w by Molmil](/molmil-images/mine/4u6w) | |
4U71
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![BU of 4u71 by Molmil](/molmil-images/mine/4u71) | |
4U75
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![BU of 4u75 by Molmil](/molmil-images/mine/4u75) | HsMetAP (F309M) in complex with Methionine | Descriptor: | COBALT (II) ION, GLYCEROL, METHIONINE, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-30 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6E
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![BU of 4u6e by Molmil](/molmil-images/mine/4u6e) | HsMetAP in complex with (amino(phenyl)methyl)phosphonic acid | Descriptor: | COBALT (II) ION, Methionine aminopeptidase 1, [(R)-amino(phenyl)methyl]phosphonic acid | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-28 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6Z
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![BU of 4u6z by Molmil](/molmil-images/mine/4u6z) | |
4U1B
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![BU of 4u1b by Molmil](/molmil-images/mine/4u1b) | HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid | Descriptor: | COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-15 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6J
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![BU of 4u6j by Molmil](/molmil-images/mine/4u6j) | HsMetAP in complex with methionine | Descriptor: | COBALT (II) ION, GLYCEROL, METHIONINE, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-29 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U6C
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![BU of 4u6c by Molmil](/molmil-images/mine/4u6c) | |
4U69
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![BU of 4u69 by Molmil](/molmil-images/mine/4u69) | HsMetAP complex with (1-amino-2-methylpentyl)phosphonic acid | Descriptor: | COBALT (II) ION, Methionine aminopeptidase 1, POTASSIUM ION, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-28 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U70
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![BU of 4u70 by Molmil](/molmil-images/mine/4u70) | |
4U76
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![BU of 4u76 by Molmil](/molmil-images/mine/4u76) | HsMetAP (F309M) holo form | Descriptor: | COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... | Authors: | Arya, T, Addlagatta, A. | Deposit date: | 2014-07-30 | Release date: | 2015-03-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015
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4U73
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2NW0
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![BU of 2nw0 by Molmil](/molmil-images/mine/2nw0) | Crystal structure of a lysin | Descriptor: | ACETATE ION, PlyB | Authors: | Porter, C.J, Buckle, A.M, Whisstock, J.C. | Deposit date: | 2006-11-14 | Release date: | 2006-12-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The 1.6 A Crystal Structure of the Catalytic Domain of PlyB, a Bacteriophage Lysin Active Against Bacillus anthracis. J.Mol.Biol., 366, 2007
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