4ZY1

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10r

Summary for 4ZY1

Entry DOI	10.2210/pdb4zy1/pdb
Related	3KQZ 4ZX8 4ZX9 4ZY0 4ZY2 4ZYQ
Descriptor	Probable M17 family aminopeptidase, N-{(1R)-2-(hydroxyamino)-1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-2-oxoethyl}-2,2-dimethylpropanamide, ZINC ION, ... (8 entities in total)
Functional Keywords	m17 leucyl-aminopeptidase, protease, inhibitor, hydroxamic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum FcB1/Columbia
Total number of polymer chains	12
Total formula weight	710157.55
Authors	Drinkwater, N.,McGowan, S. (deposition date: 2015-05-21, release date: 2016-03-30, Last modification date: 2023-09-27)
Primary citation	Drinkwater, N.,Vinh, N.B.,Mistry, S.N.,Bamert, R.S.,Ruggeri, C.,Holleran, J.P.,Loganathan, S.,Paiardini, A.,Charman, S.A.,Powell, A.K.,Avery, V.M.,McGowan, S.,Scammells, P.J. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110:43-64, 2016 Cited by PubMed: 26807544 DOI: 10.1016/j.ejmech.2016.01.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation