4ZQT
Crystal structure of PfA-M1 with virtual ligand inhibitor
Summary for 4ZQT
Entry DOI | 10.2210/pdb4zqt/pdb |
Descriptor | M1 family aminopeptidase, (2R)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, ZINC ION, ... (6 entities in total) |
Functional Keywords | aminopeptidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum 3D7 |
Total number of polymer chains | 1 |
Total formula weight | 104204.81 |
Authors | Ruggeri, C.,Drinkwater, N.,McGowan, S. (deposition date: 2015-05-11, release date: 2015-10-07, Last modification date: 2023-09-27) |
Primary citation | Ruggeri, C.,Drinkwater, N.,Sivaraman, K.K.,Bamert, R.S.,McGowan, S.,Paiardini, A. Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening. Plos One, 10:e0138957-e0138957, 2015 Cited by PubMed: 26406322DOI: 10.1371/journal.pone.0138957 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.981 Å) |
Structure validation
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