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4ZQT

Crystal structure of PfA-M1 with virtual ligand inhibitor

Summary for 4ZQT
Entry DOI10.2210/pdb4zqt/pdb
DescriptorM1 family aminopeptidase, (2R)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, ZINC ION, ... (6 entities in total)
Functional Keywordsaminopeptidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePlasmodium falciparum 3D7
Total number of polymer chains1
Total formula weight104204.81
Authors
Ruggeri, C.,Drinkwater, N.,McGowan, S. (deposition date: 2015-05-11, release date: 2015-10-07, Last modification date: 2023-09-27)
Primary citationRuggeri, C.,Drinkwater, N.,Sivaraman, K.K.,Bamert, R.S.,McGowan, S.,Paiardini, A.
Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
Plos One, 10:e0138957-e0138957, 2015
Cited by
PubMed: 26406322
DOI: 10.1371/journal.pone.0138957
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.981 Å)
Structure validation

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