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Crystal structure of PfA-M17 with virtual ligand inhibitor
Descriptor:	(2S)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, CARBONATE ION, GLYCEROL, ...
Authors:	Ruggeri, C, Drinkwater, N, McGowan, S.
Deposit date:	2015-07-01
Release date:	2015-10-07
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening. Plos One, 10, 2015

4ZQT

Crystal structure of PfA-M1 with virtual ligand inhibitor
Descriptor:	(2R)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Ruggeri, C, Drinkwater, N, McGowan, S.
Deposit date:	2015-05-11
Release date:	2015-10-07
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.981 Å)
Cite:	Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening. Plos One, 10, 2015

4K5O

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-15
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4R7M

Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Descriptor:	4-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, CARBONATE ION, DIMETHYL SULFOXIDE, ...
Authors:	Drinkwater, N, Mcgowan, S.
Deposit date:	2014-08-28
Release date:	2014-10-29
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.85 Å)
Cite:	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R5V

Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Descriptor:	GLYCEROL, M1 family aminopeptidase, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ...
Authors:	Drinkwater, N, Mcgowan, S.
Deposit date:	2014-08-22
Release date:	2014-10-29
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R5X

Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Descriptor:	3-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:	Drinkwater, N, Mcgowan, S.
Deposit date:	2014-08-22
Release date:	2014-10-29
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R76

Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Descriptor:	3-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, CARBONATE ION, M17 family aminopeptidase, ...
Authors:	Drinkwater, N, Mcgowan, S.
Deposit date:	2014-08-27
Release date:	2014-10-29
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R5T

Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, Mcgowan, S.
Deposit date:	2014-08-22
Release date:	2014-10-29
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.98 Å)
Cite:	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R6T

Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Descriptor:	CARBONATE ION, DIMETHYL SULFOXIDE, M17 leucyl aminopeptidase, ...
Authors:	Drinkwater, N, Mcgowan, S.
Deposit date:	2014-08-26
Release date:	2014-10-29
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4K5N

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-15
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.91 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5P

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-15
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K3N

Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum
Descriptor:	CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ...
Authors:	McGowan, S.
Deposit date:	2013-04-11
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5M

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-14
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5L

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-14
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.91 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4ZX5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10q
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9f
Descriptor:	M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW3

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9b
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX4

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX8

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 9b
Descriptor:	CARBONATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW8

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9r
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZY0

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10q
Descriptor:	CARBONATE ION, GLYCEROL, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(thiophen-3-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-21
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW7

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9m
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZYQ

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10s
Descriptor:	CARBONATE ION, N-{(1R)-2-(hydroxyamino)-1-[3'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl]-2-oxoethyl}-2,2-dimethylpropanamide, PENTAETHYLENE GLYCOL, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-22
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

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Total results:	29
Displayed results:	25
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