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4K3N

Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum

Summary for 4K3N
Entry DOI10.2210/pdb4k3n/pdb
DescriptorM17 leucyl aminopeptidase, ZINC ION, CARBONATE ION, ... (8 entities in total)
Functional Keywordsaminopeptidase, leucyl aminopeptidase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePlasmodium falciparum 3D7
Total number of polymer chains12
Total formula weight724928.56
Authors
McGowan, S. (deposition date: 2013-04-11, release date: 2013-06-12, Last modification date: 2023-09-20)
Primary citationKannan Sivaraman, K.,Paiardini, A.,Sienczyk, M.,Ruggeri, C.,Oellig, C.A.,Dalton, J.P.,Scammells, P.J.,Drag, M.,McGowan, S.
Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum.
J.Med.Chem., 56:5213-5217, 2013
Cited by
PubMed: 23713488
DOI: 10.1021/jm4005972
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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