4K5N

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum

Summary for 4K5N

Entry DOI	10.2210/pdb4k5n/pdb
Related	4K3N 4K5L 4K5M 4K5O 4K5P
Descriptor	M1 family aminopeptidase, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	m1 alanyl-aminopeptidase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum FcB1/Columbia
Cellular location	Cytoplasm: O96935
Total number of polymer chains	1
Total formula weight	105027.21
Authors	McGowan, S. (deposition date: 2013-04-15, release date: 2013-06-12, Last modification date: 2023-09-20)
Primary citation	Kannan Sivaraman, K.,Paiardini, A.,Sienczyk, M.,Ruggeri, C.,Oellig, C.A.,Dalton, J.P.,Scammells, P.J.,Drag, M.,McGowan, S. Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56:5213-5217, 2013 Cited by PubMed: 23713488 DOI: 10.1021/jm4005972 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation