8HBS
 
 | | Crystal of rAlfNmt | | Descriptor: | Glycylpeptide N-tetradecanoyltransferase | | Authors: | Wang, Y, Wang, S. | | Deposit date: | 2022-10-30 | | Release date: | 2023-03-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | N -Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus.
Microbiol Spectr, 11, 2023
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3B45
 | | Crystal structure of GlpG at 1.9A resolution | | Descriptor: | glpG, nonyl beta-D-glucopyranoside | | Authors: | Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. | | Deposit date: | 2007-10-23 | | Release date: | 2008-01-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG.
J.Mol.Biol., 374, 2007
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3HO1
 | | Crystal structure of T. thermophilus Argonaute N546 mutant protein complexed with DNA guide strand and 12-nt RNA target strand | | Descriptor: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*T*AP*GP*T)-3', 5'-R(P*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', MAGNESIUM ION, ... | | Authors: | Wang, Y, Li, H, Sheng, G, Patel, D.J. | | Deposit date: | 2009-06-01 | | Release date: | 2009-10-06 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
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3TDL
 | | Structure of human serum albumin in complex with DAUDA | | Descriptor: | 11-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)undecanoic acid, MYRISTIC ACID, Serum albumin | | Authors: | Wang, Y, Luo, Z, Shi, X, Wang, H, Nie, L. | | Deposit date: | 2011-08-11 | | Release date: | 2012-06-27 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin
Protein Sci., 20, 2011
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3HM9
 | | Crystal structure of T. thermophilus Argonaute complexed with DNA guide strand and 19-nt RNA target strand | | Descriptor: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | | Authors: | Wang, Y, Li, H, Sheng, G, Patel, D.J. | | Deposit date: | 2009-05-28 | | Release date: | 2009-10-06 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
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3HXM
 | | Structure of an argonaute complexed with guide DNA and target RNA duplex containing two mismatches. | | Descriptor: | Argonaute, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), MAGNESIUM ION, ... | | Authors: | Wang, Y, Li, H, Sheng, G, Patel, D.J. | | Deposit date: | 2009-06-21 | | Release date: | 2009-10-06 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
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8WJY
 | | PKMYT1_Cocrystal_Cpd 4 | | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, ... | | Authors: | Wang, Y, Wang, C, Liu, T, Qi, H, Chen, S, Cai, X, Zhang, M, Aliper, A, Ren, F, Ding, X, Zhavoronkov, A. | | Deposit date: | 2023-09-26 | | Release date: | 2023-11-22 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer.
J.Med.Chem., 67, 2024
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8K1O
 | | mycobacterial efflux pump, AMPPNP bound state | | Descriptor: | CARDIOLIPIN, MAGNESIUM ION, Multidrug efflux system ATP-binding protein Rv1218c, ... | | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | | Deposit date: | 2023-07-11 | | Release date: | 2024-07-17 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8K1M
 | | mycobacterial efflux pump, apo state | | Descriptor: | (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CARDIOLIPIN, Multidrug efflux system ATP-binding protein Rv1218c, ... | | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | | Deposit date: | 2023-07-11 | | Release date: | 2024-07-17 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8K1N
 | | mycobacterial efflux pump, substrate-bound state | | Descriptor: | CARDIOLIPIN, Multidrug efflux system ATP-binding protein Rv1218c, Multidrug efflux system permease protein Rv1217c, ... | | Authors: | Wang, Y, Wu, F, Zhang, L, Rao, Z. | | Deposit date: | 2023-07-11 | | Release date: | 2024-07-17 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9JAP
 | | Helical structure of EfAvs5(SIR2-STAND) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SIR2-like domain-containing protein | | Authors: | Wang, Y, Zheng, J. | | Deposit date: | 2024-08-25 | | Release date: | 2025-03-19 | | Last modified: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Filamentation activates bacterial Avs5 antiviral protein.
Nat Commun, 16, 2025
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3K61
 | | Crystal structure of FBF-2/fog-1 FBEa complex | | Descriptor: | 5'-R(*UP*GP*UP*AP*AP*AP*AP*UP*C)-3', Fem-3 mRNA-binding factor 2 | | Authors: | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | | Deposit date: | 2009-10-08 | | Release date: | 2009-11-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3K5Y
 | | Crystal structure of FBF-2/gld-1 FBEa complex | | Descriptor: | 5'-R(*UP*GP*UP*GP*CP*CP*AP*UP*A)-3', Fem-3 mRNA-binding factor 2 | | Authors: | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | | Deposit date: | 2009-10-08 | | Release date: | 2009-11-03 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3B44
 | | Crystal structure of GlpG W136A mutant | | Descriptor: | glpG, nonyl beta-D-glucopyranoside | | Authors: | Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. | | Deposit date: | 2007-10-23 | | Release date: | 2008-01-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG.
J.Mol.Biol., 374, 2007
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3K62
 | | Crystal structure of FBF-2/gld-1 FBEb complex | | Descriptor: | 5'-R(*UP*GP*UP*GP*UP*UP*AP*UP*C)-3', Fem-3 mRNA-binding factor 2 | | Authors: | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | | Deposit date: | 2009-10-08 | | Release date: | 2009-11-03 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
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5H74
 | | Crystal structure of T2R-TTL-14b complex | | Descriptor: | (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[hexyl-[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-fluorophenyl)-2-methyl-pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Wang, Y, Yu, Y, Chen, Q, Yang, J. | | Deposit date: | 2016-11-17 | | Release date: | 2017-11-22 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-Activity Relationship Studies of Tubulysin Analogues: Anticancer N-Alkyltubulysins with Subpicomolar Activity and the Crystal Structure Binding to Tubulin
To Be Published
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6ON3
 | | A substrate bound structure of L-DOPA dioxygenase from Streptomyces sclerotialus | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,4-DIHYDROXYPHENYLALANINE, FE (II) ION, ... | | Authors: | Wang, Y, Shin, I, Fu, Y, Colabroy, K, Liu, A. | | Deposit date: | 2019-04-19 | | Release date: | 2019-06-26 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Crystal Structures of L-DOPA Dioxygenase fromStreptomyces sclerotialus.
Biochemistry, 58, 2019
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3K64
 | | Crystal structure of FBF-2/fem-3 PME complex | | Descriptor: | 5'-R(*UP*GP*UP*GP*UP*CP*AP*UP*U)-3', Fem-3 mRNA-binding factor 2 | | Authors: | Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T. | | Deposit date: | 2009-10-08 | | Release date: | 2009-11-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
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4ESP
 | | Crystal Structure of Peanut Allergen Ara h 5 | | Descriptor: | 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Profilin | | Authors: | Wang, Y, Zhang, Y.Z. | | Deposit date: | 2012-04-23 | | Release date: | 2013-03-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Crystal Structure of Peanut ( Arachis hypogaea ) Allergen Ara h 5.
J.Agric.Food Chem., 61, 2013
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3LJQ
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2H4Z
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2H4X
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7K0K
 | | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa, 3KS-bound | | Descriptor: | 3-Dehydrosphinganine, Serine palmitoyltransferase 1, Serine palmitoyltransferase 2, ... | | Authors: | Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H. | | Deposit date: | 2020-09-04 | | Release date: | 2021-02-24 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
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7K0N
 | | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 2 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ORM1-like protein 3, Serine palmitoyltransferase 1, ... | | Authors: | Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H. | | Deposit date: | 2020-09-04 | | Release date: | 2021-02-24 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
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7K0O
 | | Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 3 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ORM1-like protein 3, Serine palmitoyltransferase 1, ... | | Authors: | Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H. | | Deposit date: | 2020-09-04 | | Release date: | 2021-02-24 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
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