4QGE
 
 | phosphodiesterase-9A in complex with inhibitor WYQ-C36D | Descriptor: | MAGNESIUM ION, N~2~-(1-cyclopentyl-4-oxo-4,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-N-(4-methoxyphenyl)-D-alaninamide, Phosphodiesterase 9A, ... | Authors: | Shao, Y.-X, Huang, M, Cui, W, Ke, H. | Deposit date: | 2014-05-22 | Release date: | 2014-12-10 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent. J.Med.Chem., 57, 2014
|
|
7MTB
 
 | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6 | Descriptor: | Fab6 heavy chain, Fab6 light chain, RETINAL, ... | Authors: | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2021-05-13 | Release date: | 2021-07-07 | Last modified: | 2024-11-06 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
|
|
7MT8
 
 | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin | Descriptor: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | Authors: | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2021-05-13 | Release date: | 2021-07-07 | Last modified: | 2024-11-20 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
|
|
7MTA
 
 | Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1 | Descriptor: | Fab1 Heavy chain, Fab1 Light chain, RETINAL, ... | Authors: | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2021-05-13 | Release date: | 2021-07-07 | Last modified: | 2024-11-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
|
|
7MT9
 
 | Rhodopsin kinase (GRK1) in complex with rhodopsin | Descriptor: | RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... | Authors: | Chen, Q, Chen, C.-L, Tesmer, J.J.G. | Deposit date: | 2021-05-13 | Release date: | 2021-07-07 | Last modified: | 2024-11-13 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
|
|
7WJQ
 
 | Crystal structure of GSDMB in complex with Ipah7.8 | Descriptor: | Isoform 2 of Gasdermin-B, Probable E3 ubiquitin-protein ligase ipaH7.8 | Authors: | Li, X, Zhang, H, Yin, H. | Deposit date: | 2022-01-07 | Release date: | 2023-01-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8 Nat Commun, 14, 2023
|
|
7MPH
 
 | GRB2 SH2 Domain with Compound 7 | Descriptor: | (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ... | Authors: | Sun, L, Schonbrunn, E. | Deposit date: | 2021-05-04 | Release date: | 2021-09-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51, 2021
|
|
5WOV
 
 | |
5WOW
 
 | |
5X3P
 
 | |
5X4L
 
 | Crystal structure of the UBX domain of human UBXD7 in complex with p97 N domain | Descriptor: | Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 7 | Authors: | Jiang, T, Li, Z, Wang, Y, Xu, M. | Deposit date: | 2017-02-13 | Release date: | 2017-03-22 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase Biochem. Biophys. Res. Commun., 486, 2017
|
|
5VT0
 
 | |
4Q1E
 
 | Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 10 {2-{[(1R/S)-1-{2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol 4-yl}ethyl]sulfanyl}pyrimidine-4,6-diamine} | Descriptor: | (R)-2-((1-(2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)ethyl)thio)pyrimidine-4,6-diamine, (S)-2-((1-(2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-5-methylthiazol-4-yl)ethyl)thio)pyrimidine-4,6-diamine, Deoxycytidine kinase, ... | Authors: | Nomme, J, Lavie, A. | Deposit date: | 2014-04-03 | Release date: | 2014-11-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. J.Med.Chem., 57, 2014
|
|
4Q1A
 
 | Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 6 {2-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethanol} | Descriptor: | 2-(5-(4-(((4,6-diaminopyrimidin-2-yl)thio)methyl)-5-propylthiazol-2-yl)-2-methoxyphenoxy)ethan-1-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | Authors: | Nomme, J, Lavie, A. | Deposit date: | 2014-04-03 | Release date: | 2015-02-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. J.Med.Chem., 57, 2014
|
|
5XIW
 
 | Crystal structure of T2R-TTL-Colchicine complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | Authors: | Wang, Y, Yang, J, Wang, T, Chen, L. | Deposit date: | 2017-04-27 | Release date: | 2018-04-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. J. Biol. Chem., 2018
|
|
7FCA
 
 | PfkB(Mycobacterium marinum) | Descriptor: | Fructokinase, PfkB, GLYCEROL, ... | Authors: | Li, J, Gao, B, Ji, R. | Deposit date: | 2021-07-14 | Release date: | 2021-08-04 | Last modified: | 2025-03-12 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural analysis and functional study of phosphofructokinase B (PfkB) from Mycobacterium marinum. Biochem.Biophys.Res.Commun., 579, 2021
|
|
3OW8
 
 | Crystal Structure of the WD repeat-containing protein 61 | Descriptor: | UNKNOWN ATOM OR ION, WD repeat-containing protein 61 | Authors: | Tempel, W, Li, Z, Chao, X, Lam, R, Wernimont, A.K, He, H, Seitova, A, Pan, P.W, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2010-09-17 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and function of WD40 domain proteins. Protein Cell, 2, 2011
|
|
7VBT
 
 | Crystal structure of RIOK2 in complex with CQ211 | Descriptor: | 8-(6-methoxypyridin-3-yl)-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]-5H-[1,2,3]triazolo[4,5-c]quinolin-4-one, Serine/threonine-protein kinase RIO2 | Authors: | Zhu, C, Zhang, Z.M. | Deposit date: | 2021-09-01 | Release date: | 2022-07-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.54001474 Å) | Cite: | Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro- 4H -[1,2,3]triazolo[4,5- c ]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J.Med.Chem., 65, 2022
|
|
9G7E
 
 | |
9G76
 
 | Crystal structure of ASGPR with bound GalNAc | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-galactopyranose, Asialoglycoprotein receptor 1, ... | Authors: | Schreuder, H.A, Hofmeister, A. | Deposit date: | 2024-07-19 | Release date: | 2025-03-19 | Last modified: | 2025-04-09 | Method: | X-RAY DIFFRACTION (1.199 Å) | Cite: | Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo. J.Med.Chem., 68, 2025
|
|
9G7D
 
 | Crystal structure of ASGPR with bound IMP | Descriptor: | Asialoglycoprotein receptor 1, CALCIUM ION, INOSINIC ACID | Authors: | Schreuder, H.A, Hofmeister, A. | Deposit date: | 2024-07-20 | Release date: | 2025-03-19 | Last modified: | 2025-04-09 | Method: | X-RAY DIFFRACTION (1.588 Å) | Cite: | Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo. J.Med.Chem., 68, 2025
|
|
9IZN
 
 | Crystal structure of HKU1A RBD bound to TMPRSS2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, Transmembrane protease serine 2 | Authors: | Wang, W, Xu, Y, Zhang, S. | Deposit date: | 2024-08-01 | Release date: | 2024-10-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | High-resolution crystal structure of human coronavirus HKU1 receptor binding domain bound to TMPRSS2 receptor Hlife, 2024
|
|
9IW3
 
 | Cryo-EM structure of Lactobacillus casei DdmE bound with guide and target | Descriptor: | DNA (25-MER), DNA (5'-D(P*CP*TP*TP*GP*AP*TP*AP*CP*GP*AP*C)-3'), DNA (5'-D(P*TP*GP*AP*CP*GP*GP*CP*TP*CP*TP*AP*AP*TP*CP*T)-3'), ... | Authors: | Huang, P.P, Chen, M.R, Xiao, Y.B. | Deposit date: | 2024-07-25 | Release date: | 2025-01-01 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | The mechanism of bacterial defense system DdmDE from Lactobacillus casei. Cell Res., 34, 2024
|
|
9IX4
 
 | Cryo-EM structure of Lactobacillus casei DdmD dimer bound with DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*AP*TP*GP*AP*GP*TP*AP*TP*AP*TP*CP*C)-3'), ... | Authors: | Huang, P.P, Chen, M.R, Xiao, Y.B. | Deposit date: | 2024-07-26 | Release date: | 2025-01-01 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | The mechanism of bacterial defense system DdmDE from Lactobacillus casei. Cell Res., 34, 2024
|
|
9IXM
 
 | Cryo-EM structure of Lactobacillus casei DdmDE bound with DNA | Descriptor: | DNA (30-MER), DNA (5'-D(P*TP*GP*AP*CP*GP*GP*CP*TP*CP*TP*AP*AP*TP*CP*T)-3'), DdmD, ... | Authors: | Huang, P.P, Chen, M.R, Xiao, Y.B. | Deposit date: | 2024-07-29 | Release date: | 2025-01-01 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | The mechanism of bacterial defense system DdmDE from Lactobacillus casei. Cell Res., 34, 2024
|
|