7VBT

Crystal structure of RIOK2 in complex with CQ211

Summary for 7VBT

Entry DOI	10.2210/pdb7vbt/pdb
Descriptor	Serine/threonine-protein kinase RIO2, 8-(6-methoxypyridin-3-yl)-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]-5H-[1,2,3]triazolo[4,5-c]quinolin-4-one (3 entities in total)
Functional Keywords	riok2, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	75148.01
Authors	Zhu, C.,Zhang, Z.M. (deposition date: 2021-09-01, release date: 2022-07-06, Last modification date: 2023-11-29)
Primary citation	Ouyang, Y.,Si, H.,Zhu, C.,Zhong, L.,Ma, H.,Li, Z.,Xiong, H.,Liu, T.,Liu, Z.,Zhang, Z.,Zhang, Z.M.,Cai, Q. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro- 4H -[1,2,3]triazolo[4,5- c ]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J.Med.Chem., 65:7833-7842, 2022 Cited by PubMed: 35584513 DOI: 10.1021/acs.jmedchem.2c00271 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.54001480108 Å)

Structure validation