5AJJ
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2J47
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![BU of 2j47 by Molmil](/molmil-images/mine/2j47) | Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with a imidazole-pugnac hybrid inhibitor | Descriptor: | (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE, GLUCOSAMINIDASE, GLYCEROL | Authors: | Dennis, R.J, Davies, G.J. | Deposit date: | 2006-08-25 | Release date: | 2006-10-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Inhibition of O-Glcnacase by a Gluco-Configured Nagstatin and a Pugnac-Imidazole Hybrid Inhibitor Chem. Commun., 42, 2006
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3LCA
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1JBK
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3KQI
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![BU of 3kqi by Molmil](/molmil-images/mine/3kqi) | crystal structure of PHF2 PHD domain complexed with H3K4Me3 peptide | Descriptor: | CHLORIDE ION, GLYCEROL, H3K4Me3 peptide, ... | Authors: | Wen, H, Li, J.Z, Song, T, Lu, M, Lee, M. | Deposit date: | 2009-11-17 | Release date: | 2010-02-02 | Last modified: | 2019-02-13 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J.Biol.Chem., 285, 2010
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3QFP
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![BU of 3qfp by Molmil](/molmil-images/mine/3qfp) | Crystal structure of yeast Hsp70 (Bip/Kar2) ATPase domain | Descriptor: | 78 kDa glucose-regulated protein homolog, PHOSPHATE ION | Authors: | Yan, M, Li, J.Z, Sha, B.D. | Deposit date: | 2011-01-22 | Release date: | 2011-06-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
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3QML
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![BU of 3qml by Molmil](/molmil-images/mine/3qml) | The structural analysis of Sil1-Bip complex reveals the mechanism for Sil1 to function as a novel nucleotide exchange factor | Descriptor: | 78 kDa glucose-regulated protein homolog, MAGNESIUM ION, Nucleotide exchange factor SIL1, ... | Authors: | Yan, M, Li, J.Z, Sha, B.D. | Deposit date: | 2011-02-04 | Release date: | 2011-06-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
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3QFU
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![BU of 3qfu by Molmil](/molmil-images/mine/3qfu) | Crystal structure of Yeast Hsp70 (Bip/kar2) complexed with ADP | Descriptor: | 78 kDa glucose-regulated protein homolog, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yan, M, Li, J.Z, Sha, B.D. | Deposit date: | 2011-01-22 | Release date: | 2011-06-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
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3QLE
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![BU of 3qle by Molmil](/molmil-images/mine/3qle) | Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase | Descriptor: | ACETATE ION, CALCIUM ION, PENTAETHYLENE GLYCOL, ... | Authors: | Qian, X.G, Gebert, M, Hpker, J, Yan, M, Li, J.Z, Wiedemann, N, Laan, M.V.D, Pfanner, N, Sha, B.D. | Deposit date: | 2011-02-02 | Release date: | 2011-03-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.831 Å) | Cite: | Structural basis for the function of tim50 in the mitochondrial presequence translocase. J.Mol.Biol., 411, 2011
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3QD2
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![BU of 3qd2 by Molmil](/molmil-images/mine/3qd2) | Crystal structure of mouse PERK kinase domain | Descriptor: | Eukaryotic translation initiation factor 2-alpha kinase 3 | Authors: | Wenjun, C, Jingzhi, L, David, R, Bingdong, S. | Deposit date: | 2011-01-17 | Release date: | 2011-04-27 | Last modified: | 2019-01-16 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | The structure of the PERK kinase domain suggests the mechanism for its activation. Acta Crystallogr.,Sect.D, 67, 2011
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4QQF
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6P7M
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![BU of 6p7m by Molmil](/molmil-images/mine/6p7m) | Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (1:2 complex) | Descriptor: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | Authors: | Knott, G.J, Liu, J.J, Doudna, J.A. | Deposit date: | 2019-06-06 | Release date: | 2019-08-21 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. Elife, 8, 2019
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6P7N
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![BU of 6p7n by Molmil](/molmil-images/mine/6p7n) | Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (2:2 complex) | Descriptor: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | Authors: | Knott, G.J, Liu, J.J, Doudna, J.A. | Deposit date: | 2019-06-06 | Release date: | 2019-08-21 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. Elife, 8, 2019
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2HHB
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5K0M
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![BU of 5k0m by Molmil](/molmil-images/mine/5k0m) | Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED | Descriptor: | (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine, Polycomb protein EED | Authors: | Jakob, C.G, Bigelow, L.J, Zhu, H, Sun, C. | Deposit date: | 2016-05-17 | Release date: | 2017-01-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat. Chem. Biol., 13, 2017
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4RG5
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![BU of 4rg5 by Molmil](/molmil-images/mine/4rg5) | Crystal Structure of S. Pombe SMN YG-Dimer | Descriptor: | MALONATE ION, Maltose-binding periplasmic protein, Survival Motor Neuron protein chimera, ... | Authors: | Gupta, K, Martin, R.S, Sarachan, K.L, Sharp, B, Van Duyne, G.D. | Deposit date: | 2014-09-29 | Release date: | 2015-07-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Oligomeric Properties of Survival Motor NeuronGemin2 Complexes. J.Biol.Chem., 290, 2015
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5KJ2
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![BU of 5kj2 by Molmil](/molmil-images/mine/5kj2) | The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer | Descriptor: | Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION | Authors: | Jakob, C.G, Qiu, W, Edalji, R.P, Sun, C. | Deposit date: | 2016-06-17 | Release date: | 2017-09-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature, 550, 2017
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6UUM
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![BU of 6uum by Molmil](/molmil-images/mine/6uum) | Crystal structure of antibody 438-B11 DSS mutant (Cys98A-Cys100aA) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, B11 DSS Fab Heavy Chain, ... | Authors: | Kumar, S, Wilson, I.A. | Deposit date: | 2019-10-30 | Release date: | 2020-09-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite. Sci Adv, 6, 2020
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6UUL
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![BU of 6uul by Molmil](/molmil-images/mine/6uul) | Crystal structure of broad and potent HIV-1 neutralizing antibody 438-D5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, D5 Fab Heavy Chain, ... | Authors: | Kumar, S, Wilson, I.A. | Deposit date: | 2019-10-30 | Release date: | 2020-09-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite. Sci Adv, 6, 2020
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6UTK
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6UUH
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6V6W
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8OER
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![BU of 8oer by Molmil](/molmil-images/mine/8oer) | MUC5B amino acids 26-1435 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-5B | Authors: | Khmelnitsky, L, Fass, D. | Deposit date: | 2023-03-12 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Pulmonary Fibrosis Linked to Impaired Mucin 5B Supramolecular Assembly To Be Published
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8OES
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![BU of 8oes by Molmil](/molmil-images/mine/8oes) | MUC5B amino acids 26-1435 Three beads | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mucin-5B | Authors: | Khmelnitsky, L, Fass, D. | Deposit date: | 2023-03-12 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Pulmonary Fibrosis Linked to Impaired Mucin 5B Supramolecular Assembly To Be Published
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6ORE
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![BU of 6ore by Molmil](/molmil-images/mine/6ore) | Release complex 70S | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Fu, Z. | Deposit date: | 2019-04-30 | Release date: | 2019-06-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy. Nat Commun, 10, 2019
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