6UTK

Crystal structure of 438-B11 Fab in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22 at 3.80 Angstrom

Summary for 6UTK

• Entry DOI: 10.2210/pdb6utk/pdb
• Descriptor: 35O22 Fab Heavy Chain, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (16 entities in total)
• Functional Keywords: hiv-1 gp160, glycan supersite, human antibody, immune system, viral-protein complex, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 181894.26

Authors

Kumar, S.,Wilson, I.A. (deposition date: 2019-10-29, release date: 2020-09-23, Last modification date: 2023-10-11)

• Primary citation: Kumar, S.,Ju, B.,Shapiro, B.,Lin, X.,Ren, L.,Zhang, L.,Li, D.,Zhou, Z.,Feng, Y.,Sou, C.,Mann, C.J.,Hao, Y.,Sarkar, A.,Jou, J.,Nunnally, C.,Hong, K.,Wang, S.,Ge, X.,Su, B.,Landais, E.,Sok, D.,Zwick, M.B.,He, L.,Zhu, J.,Wilson, I.A.,Shao, Z.; A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite; Sci Adv, 6:eabb1328-, 2020; DOI: 10.1126/sciadv.abb1328

Experimental method

X-RAY DIFFRACTION (3.8 Å)