6V6W

Crystal structure of antibody 438-B11 DSS mutant (Cys98A-100aA) in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22

Summary for 6V6W

• Entry DOI: 10.2210/pdb6v6w/pdb
• Related: 6UTK
• Descriptor: 35O22 Fab Heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Fab Light chain, ... (10 entities in total)
• Functional Keywords: hiv-1 gp160, glycan supersite, human antibody, immune system, viral-protein complex, viral protein-immune system complex, viral protein, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 344683.21

Authors

Kumar, S.,Wilson, I.A. (deposition date: 2019-12-06, release date: 2020-09-23, Last modification date: 2023-10-11)

• Primary citation: Kumar, S.,Ju, B.,Shapero, B.,Lin, X.,Ren, L.,Zhang, L.,Li, D.,Zhou, Z.,Feng, Y.,Sou, C.,Mann, C.J.,Hao, Y.,Sarkar, A.,Hou, J.,Nunnally, C.,Hong, K.,Wang, S.,Ge, X.,Su, B.,Landais, E.,Sok, D.,Zwick, M.B.,He, L.,Zhu, J.,Wilson, I.A.,Shao, Y.; A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite; Sci Adv, 6:eabb1328-, 2020; DOI: 10.1126/sciadv.abb1328

Experimental method

X-RAY DIFFRACTION (6.5 Å)