6V6W
Crystal structure of antibody 438-B11 DSS mutant (Cys98A-100aA) in complex with an uncleaved prefusion optimized (UFO) soluble BG505 trimer and Fab 35O22
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G (D, A) | 35O22 Fab Heavy chain | polymer | 243 | 26171.5 | 2 | Human immunodeficiency virus 1 | ||
| 2 | B, H (E, B) | 35O22 Fab Light chain | polymer | 216 | 23318.8 | 2 | Human immunodeficiency virus 1 | ||
| 3 | C, I (G, C) | Envelope glycoprotein gp120 | polymer | 485 | 53737.6 | 2 | UniProt (Q2N0S6) Pfam (PF00516) | Human immunodeficiency virus 1 (HIV-1) | |
| 4 | D, J (I, F) | B11 DSS Fab heavy chain | polymer | 235 | 25227.5 | 2 | Human immunodeficiency virus 1 | ||
| 5 | E, K (J, H) | B11 Fab light chain | polymer | 215 | 23445.0 | 2 | Human immunodeficiency virus 1 | ||
| 6 | F, L (T, K) | Envelope glycoprotein gp41 | polymer | 140 | 15702.7 | 2 | UniProt (Q2N0S9) Pfam (PF00517) | Human immunodeficiency virus 1 | Env polyprotein |
| 7 | M, P (L, O) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 8 | N, Q (M, P) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 9 | O, R (N, Q) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 10 | AA, BA, CA, DA, EA... (G, T, C, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 24 | Chemie (NAG) |
Sequence modifications
G, C: 31 - 506 (UniProt: Q2N0S6)
T, K: 512 - 664 (UniProt: Q2N0S9)
| PDB | External Database | Details |
|---|---|---|
| Asp 62 | Glu 61 | conflict |
| Asn 332 | Thr 330 | conflict |
| Cys 501 | Ala 498 | conflict |
| Gly 507 | - | expression tag |
| Gly 508 | - | expression tag |
| Gly 509 | - | expression tag |
| Gly 510 | - | expression tag |
| Gly 511 | - | expression tag |
| Ser 512 | - | expression tag |
| Gly 513 | - | expression tag |
| Gly 514 | - | expression tag |
| Gly 515 | - | expression tag |
| Gly 516 | - | expression tag |
| Ser 517 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| - | Ile 547 | deletion |
| - | Val 548 | deletion |
| - | Gln 549 | deletion |
| - | Gln 550 | deletion |
| - | Gln 551 | deletion |
| - | Ser 552 | deletion |
| - | Asn 553 | deletion |
| - | Leu 554 | deletion |
| - | Leu 555 | deletion |
| - | Arg 556 | deletion |
| - | Ala 557 | deletion |
| - | Ile 558 | deletion |
| - | Glu 559 | deletion |
| Asn 547 | Ala 560 | conflict |
| Pro 547 | Gln 561 | conflict |
| Asp 547 | Gln 562 | conflict |
| Trp 547 | His 563 | conflict |
| Pro 547 | Leu 565 | conflict |
| Asp 547 | Lys 566 | conflict |
| Met 547 | Leu 567 | conflict |
| Cys 605 | Thr 604 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 335206.4 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 4167.8 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 5309.0 | |
| All* | Total formula weight | 344683.2 |
