2J47

Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with a imidazole-pugnac hybrid inhibitor

Summary for 2J47

Entry DOI	10.2210/pdb2j47/pdb
Related	2CHN 2CHO
Descriptor	GLUCOSAMINIDASE, (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE, GLYCEROL, ... (4 entities in total)
Functional Keywords	inhibitor, o-glcnacase, imidazole, gh84, pugnac, enzyme, inhibition
Biological source	BACTEROIDES THETAIOTAOMICRON
Total number of polymer chains	1
Total formula weight	82769.57
Authors	Dennis, R.J.,Davies, G.J. (deposition date: 2006-08-25, release date: 2006-10-03, Last modification date: 2023-12-13)
Primary citation	Shanmugasundaram, B.,Debowski, A.W.,Dennis, R.J.,Davies, G.J.,Vocadlo, D.J.,Vasella, A. Inhibition of O-Glcnacase by a Gluco-Configured Nagstatin and a Pugnac-Imidazole Hybrid Inhibitor Chem. Commun., 42:4372-, 2006 Cited by PubMed: 17057847 DOI: 10.1039/B612154C PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation