5WFE
 
 | | Cas1-Cas2-IHF-DNA holo-complex | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | | Authors: | Wright, A.V, Liu, J.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2017-07-11 | | Release date: | 2017-08-02 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | Structures of the CRISPR genome integration complex.
Science, 357, 2017
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9CC8
 | | Hexameric state of the NRC4 resistosome | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, NLR-required for cell death 4 | | Authors: | Liu, F, Yang, Z, Nogales, E, Staskawicz, B.J. | | Deposit date: | 2024-06-21 | | Release date: | 2024-09-11 | | Last modified: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Activation of the helper NRC4 immune receptor forms a hexameric resistosome.
Cell, 187, 2024
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9CC9
 | | Dodecameric state of the NRC4 resistosome | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, NLR-required for cell death 4 | | Authors: | Liu, F, Yang, Z, Nogales, E, Staskawicz, B.J. | | Deposit date: | 2024-06-21 | | Release date: | 2024-09-11 | | Last modified: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Activation of the helper NRC4 immune receptor forms a hexameric resistosome.
Cell, 187, 2024
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5VZL
 | | cryo-EM structure of the Cas9-sgRNA-AcrIIA4 anti-CRISPR complex | | Descriptor: | CRISPR-associated endonuclease Cas9, phage anti-CRISPR AcrIIA4, single guide RNA (116-MER) | | Authors: | Jiang, F, Liu, J.J, Nogales, E, Doudna, J.A. | | Deposit date: | 2017-05-29 | | Release date: | 2017-07-26 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Disabling Cas9 by an anti-CRISPR DNA mimic.
Sci Adv, 3, 2017
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9DHZ
 | | Cryo-EM structure of HURP bound to a microtubule | | Descriptor: | Disks large-associated protein 5, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Perez-Bertoldi, J.M, Nogales, E. | | Deposit date: | 2024-09-04 | | Release date: | 2025-07-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | HURP regulates Kif18A recruitment and activity to synergistically control microtubule dynamics.
Nat Commun, 15, 2024
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9DI0
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9DXC
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9DXE
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6XD3
 | | Structure of the human CAK in complex with THZ1 | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Greber, B.J, Perez-Bertoldi, J.M, Lim, K, Iavarone, A.T, Toso, D.B, Nogales, E. | | Deposit date: | 2020-06-09 | | Release date: | 2020-09-09 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | The cryoelectron microscopy structure of the human CDK-activating kinase.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6XBZ
 | | Structure of the human CDK-activating kinase | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Greber, B.J, Perez-Bertoldi, J.M, Lim, K, Iavarone, A.T, Toso, D.B, Nogales, E. | | Deposit date: | 2020-06-07 | | Release date: | 2020-09-09 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | The cryoelectron microscopy structure of the human CDK-activating kinase.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6WKR
 | | PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome | | Descriptor: | DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. | | Deposit date: | 2020-04-16 | | Release date: | 2021-02-03 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.
Science, 371, 2021
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6WCQ
 | | Structure of a substrate-bound DQC ubiquitin ligase | | Descriptor: | Cullin-1, F-box/LRR-repeat protein 17, Kelch-like ECH-associated protein 1, ... | | Authors: | Mena, E.L, Jevtic, P, Greber, B.J, Gee, C.L, Lew, B.G, Akopian, D, Nogales, E, Kuriyan, J, Rape, M. | | Deposit date: | 2020-03-31 | | Release date: | 2020-08-19 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (8.5 Å) | | Cite: | Structural basis for dimerization quality control.
Nature, 586, 2020
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7SGS
 | | Cryo-EM structure of full-length MAP7 bound to the microtubule | | Descriptor: | Ensconsin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Ferro, L.S, Fang, Q, Eshun-Wilson, L, Fernandes, J, Jack, A, Farrell, D.P, Golcuk, M, Huijben, T, Costa, K, Gur, M, DiMaio, F, Nogales, E, Yildiz, A. | | Deposit date: | 2021-10-07 | | Release date: | 2022-05-18 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7.
Science, 375, 2022
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5IJ9
 | | Cryo EM density of microtubule assembled from human TUBB3-D417H mutant | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Ti, S.C, Pamula, M.C, Howes, S.C, Duellberg, C, Cade, N.I, Kleiner, R.E, Forth, S, Surrey, T, Nogales, E, Kapoor, T.M. | | Deposit date: | 2016-03-01 | | Release date: | 2016-04-20 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.
Dev.Cell, 37, 2016
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5IJ0
 | | Cryo EM density of microtubule assembled from human TUBB3 | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Ti, S.-C, Pamula, M.C, Howes, S.C, Duellberg, C, Nicholas, C.I, Kleiner, R.E, Forth, S, Surrey, T, Nogales, E, Kapoor, T.M. | | Deposit date: | 2016-03-01 | | Release date: | 2016-04-20 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.
Dev.Cell, 37, 2016
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5IY8
 | | Human holo-PIC in the initial transcribing state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (7.9 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IY6
 | | Human holo-PIC in the closed state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (7.2 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IY9
 | | Human holo-PIC in the initial transcribing state (no IIS) | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (6.3 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IYB
 | | Human core-PIC in the open state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IYC
 | | Human core-PIC in the initial transcribing state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IYD
 | | Human core-PIC in the initial transcribing state (no IIS) | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IVW
 | | Human core TFIIH bound to DNA within the PIC | | Descriptor: | General transcription factor IIH subunit 2, General transcription factor IIH subunit 3, General transcription factor IIH subunit 4, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-21 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (10 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IY7
 | | Human holo-PIC in the open state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (8.6 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IYA
 | | Human core-PIC in the closed state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (5.4 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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6NY3
 | | CasX ternary complex with 30bp target DNA | | Descriptor: | CasX, DNA Non-target strand, DNA target strand, ... | | Authors: | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | Deposit date: | 2019-02-10 | | Release date: | 2019-02-27 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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