6IZQ
 
 | | PRMT4 bound with a bicyclic compound | | Descriptor: | (2R)-1-(methylamino)-3-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)propan-2-ol, Histone-arginine methyltransferase CARM1 | | Authors: | Xiong, B, Cao, D.Y, Guo, Z.H, Li, Y.L, Li, J, Huang, X, Shen, J.K. | | Deposit date: | 2018-12-20 | | Release date: | 2019-12-25 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.449 Å) | | Cite: | Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
J.Med.Chem., 62, 2019
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3HC5
 | | FXR with SRC1 and GSK826 | | Descriptor: | 3-(6-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1-benzothiophen-2-yl)benzoic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... | | Authors: | Williams, S.P, Madauss, K.P. | | Deposit date: | 2009-05-05 | | Release date: | 2009-07-21 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | FXR agonist activity of conformationally constrained analogs of GW 4064.
Bioorg.Med.Chem.Lett., 19, 2009
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6J9O
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3HC6
 | | FXR with SRC1 and GSK088 | | Descriptor: | 3-[(5-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1H-indol-1-yl)methyl]benzoic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... | | Authors: | Williams, S.P, Madauss, K.P. | | Deposit date: | 2009-05-05 | | Release date: | 2009-07-21 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | FXR agonist activity of conformationally constrained analogs of GW 4064.
Bioorg.Med.Chem.Lett., 19, 2009
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3IM4
 | | Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in complex with dual-specific A-Kinase Anchoring Protein 2 | | Descriptor: | Dual specificity A kinase-anchoring protein 2, ZINC ION, cAMP-dependent protein kinase type I-alpha regulatory subunit | | Authors: | Sarma, G.N, Kinderman, F.S, Kim, C, von Daake, S, Taylor, S.S. | | Deposit date: | 2009-08-09 | | Release date: | 2010-02-02 | | Last modified: | 2022-12-21 | | Method: | X-RAY DIFFRACTION (2.285 Å) | | Cite: | Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity
Structure, 18, 2010
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6NF0
 | | Nocturnin with bound NADPH substrate | | Descriptor: | CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Nocturnin | | Authors: | Estrella, M.A, Du, J, Korennykh, A. | | Deposit date: | 2018-12-18 | | Release date: | 2019-05-01 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The metabolites NADP+and NADPH are the targets of the circadian protein Nocturnin (Curled).
Nat Commun, 10, 2019
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4DXQ
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3IM3
 | | Crystal structure of PKA RI alpha dimerization/docking domain | | Descriptor: | FORMIC ACID, cAMP-dependent protein kinase type I-alpha regulatory subunit | | Authors: | Sarma, G.N, Kinderman, F.S, Kim, C, von Daake, S, Taylor, S.S. | | Deposit date: | 2009-08-09 | | Release date: | 2010-02-02 | | Last modified: | 2021-04-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity
Structure, 18, 2010
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4B04
 | | Crystal structure of the Catalytic Domain of Human DUSP26 (C152S) | | Descriptor: | DUAL SPECIFICITY PROTEIN PHOSPHATASE 26 | | Authors: | Won, E.-Y, Lee, D.Y, Park, S.G, Yokoyama, S, Kim, S.J, Chi, S.-W. | | Deposit date: | 2012-06-28 | | Release date: | 2013-05-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.205 Å) | | Cite: | High-Resolution Crystal Structure of the Catalytic Domain of Human Dual-Specificity Phosphatase 26
Acta Crystallogr.,Sect.D, 69, 2013
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4DXP
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4DXM
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4DXI
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4DXN
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4DXO
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4EN1
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8IT9
 | | Co-crystal structure of FTO bound to 22 | | Descriptor: | 2-OXOGLUTARIC ACID, 2-[(2,6-diethyl-4-pyridin-4-yl-phenyl)amino]-6-(1,4-oxazepan-4-ylmethyl)benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO | | Authors: | Yang, C.-G, Gan, J.H. | | Deposit date: | 2023-03-22 | | Release date: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties.
J.Med.Chem., 66, 2023
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8JHQ
 | | Cryo-EM structure of human S1P transporter SPNS2 bound with S1P | | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2,GlgA glycogen synthase | | Authors: | Pang, B, Yu, L.Y, Ren, R.B. | | Deposit date: | 2023-05-25 | | Release date: | 2024-01-10 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport.
Cell Res., 34, 2024
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8JHR
 | | Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d | | Descriptor: | 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2 | | Authors: | Pang, B, Yu, L.Y, Ren, R.B. | | Deposit date: | 2023-05-25 | | Release date: | 2024-01-10 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport.
Cell Res., 34, 2024
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8U66
 | | Firmicutes Rubisco | | Descriptor: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, Rubisco | | Authors: | Kaeser, B.P, Liu, A.K, Shih, P.M. | | Deposit date: | 2023-09-13 | | Release date: | 2023-11-22 | | Last modified: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.21 Å) | | Cite: | Deep-branching evolutionary intermediates reveal structural origins of form I rubisco.
Curr.Biol., 33, 2023
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8QBJ
 | | Structure of mBaoJin at pH 4.6 | | Descriptor: | CHLORIDE ION, mBaoJin | | Authors: | Samygina, V.R, Vlaskina, A.V, Gabdulkhakov, A, Subach, O.M, Subach, F.V. | | Deposit date: | 2023-08-24 | | Release date: | 2023-12-27 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Bright and stable monomeric green fluorescent protein derived from StayGold.
Nat.Methods, 21, 2024
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8QDD
 | | Structure of mBaoJin at pH 8.5 | | Descriptor: | CHLORIDE ION, SULFATE ION, mBaoJin | | Authors: | Samygina, V.R, Vlaskina, A.V, Gabdulkhakov, A, Subach, O.M, Subach, F.V. | | Deposit date: | 2023-08-28 | | Release date: | 2023-12-27 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Bright and stable monomeric green fluorescent protein derived from StayGold.
Nat.Methods, 21, 2024
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6J4P
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6J4V
 | | Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications | | Descriptor: | GLYCEROL, PHOSPHATE ION, Small vasohibin-binding protein, ... | | Authors: | Wang, N, Bao, H, Huang, H. | | Deposit date: | 2019-01-10 | | Release date: | 2019-05-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Nat.Struct.Mol.Biol., 26, 2019
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6J4Q
 | | Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications | | Descriptor: | GLYCEROL, N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]-4-methyl-benzenesulfonamide, Small vasohibin-binding protein, ... | | Authors: | Wang, N, Bao, H, Huang, H. | | Deposit date: | 2019-01-10 | | Release date: | 2019-05-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Nat.Struct.Mol.Biol., 26, 2019
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6J4O
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