1Z8T
 
 | | Structure of Mutant Pyrrolidone Carboxyl Peptidase (E192Q) from a Hyperthermophile, Pyrococcus furiosus | | Descriptor: | Pyrrolidone-carboxylate peptidase | | Authors: | Kaushik, J.K, Yamagata, Y, Ogasahara, K, Yutani, K. | | Deposit date: | 2005-03-31 | | Release date: | 2006-06-13 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Completely buried, non-ion-paired glutamic acid contributes favorably to the conformational stability of pyrrolidone carboxyl peptidases from hyperthermophiles.
Biochemistry, 45, 2006
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3PCV
 | | Crystal structure analysis of human leukotriene C4 synthase at 1.9 angstrom resolution | | Descriptor: | 1,2-ETHANEDIOL, DODECYL-BETA-D-MALTOSIDE, GLUTATHIONE, ... | | Authors: | Saino, H, Ago, H, Miyano, M. | | Deposit date: | 2010-10-22 | | Release date: | 2011-03-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The catalytic architecture of leukotriene C4 synthase with two arginine residues
J.Biol.Chem., 286, 2011
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1S1F
 | | Crystal Structure of Streptomyces Coelicolor A3(2) CYP158A2 from antibiotic biosynthetic pathways | | Descriptor: | 4-PHENYL-1H-IMIDAZOLE, GLYCEROL, MALONIC ACID, ... | | Authors: | Zhao, B, Lamb, D.C, Lei, L, Sundaramoorthy, M, Podust, L.M, Waterman, M.R. | | Deposit date: | 2004-01-06 | | Release date: | 2005-01-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2
J.Biol.Chem., 280, 2005
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1V7O
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1SE6
 | | Crystal Structure of Streptomyces Coelicolor A3(2) CYP158A2 from antibiotic biosynthetic pathways | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PROTOPORPHYRIN IX CONTAINING FE, SPERMINE (FULLY PROTONATED FORM), ... | | Authors: | Zhao, B, Lamb, D.C, Lei, L, Sundaramoorthy, M, Podust, L.M, Waterman, M.R. | | Deposit date: | 2004-02-16 | | Release date: | 2005-01-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2.
J.Biol.Chem., 280, 2005
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1T93
 | | Evidence for Multiple Substrate Recognition and Molecular Mechanism of C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2) | | Descriptor: | FLAVIOLIN, PROTOPORPHYRIN IX CONTAINING FE, putative cytochrome P450 | | Authors: | Zhao, B, Sundaramoorthy, M, Waterman, M.R. | | Deposit date: | 2004-05-14 | | Release date: | 2005-01-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2.
J.Biol.Chem., 280, 2005
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5XCO
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5X9D
 | | Crystal structure of homoserine dehydrogenase in complex with L-cysteine and NAD | | Descriptor: | (2R)-3-[[(4S)-3-aminocarbonyl-1-[(2R,3R,4S,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]-4H-pyridin-4-yl]sulfanyl]-2-azanyl-propanoic acid, Homoserine dehydrogenase, L(+)-TARTARIC ACID | | Authors: | Goto, M, Ogata, K, Kaneko, R, Yoshimune, K. | | Deposit date: | 2017-03-06 | | Release date: | 2018-05-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Inhibition of homoserine dehydrogenase by formation of a cysteine-NAD covalent complex
Sci Rep, 8, 2018
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3AUF
 | | Crystal structure of glycinamide ribonucleotide transformylase 1 from Symbiobacterium toebii | | Descriptor: | Glycinamide ribonucleotide transformylase 1 | | Authors: | Kanagawa, M, Baba, S, Nagira, T, Kuramitsu, S, Yokoyama, S, Sampei, G, Kawai, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2011-02-03 | | Release date: | 2012-03-07 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Structures and reaction mechanisms of the two related enzymes, PurN and PurU.
J.Biochem., 154, 2013
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1WZU
 | | Crystal structure of quinolinate synthase (nadA) | | Descriptor: | D-MALATE, Quinolinate synthetase A | | Authors: | Sakuraba, H. | | Deposit date: | 2005-03-09 | | Release date: | 2005-06-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of the NAD Biosynthetic Enzyme Quinolinate Synthase
J.Biol.Chem., 280, 2005
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487D
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7CME
 | | Crystal structure of human P-cadherin MEC12 (X dimer) in complex with 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine (inhibitor) | | Descriptor: | 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine, CALCIUM ION, Cadherin-3, ... | | Authors: | Senoo, A, Ito, S, Ueno, G, Nagatoishi, S, Tsumoto, K. | | Deposit date: | 2020-07-27 | | Release date: | 2021-09-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion
Commun Biol, 4, 2021
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7CMF
 | | Crystal structure of human P-cadherin REC12 (monomer) in complex with 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine (inhibitor) | | Descriptor: | 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine, CALCIUM ION, Cadherin-3 | | Authors: | Senoo, A, Ito, S, Ueno, G, Nagatoishi, S, Tsumoto, K. | | Deposit date: | 2020-07-27 | | Release date: | 2021-09-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion
Commun Biol, 4, 2021
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3W7B
 | | Crystal structure of formyltetrahydrofolate deformylase from Thermus thermophilus HB8 | | Descriptor: | Formyltetrahydrofolate deformylase | | Authors: | Sampei, G, Yanagida, Y, Ogata, N, Kusano, M, Terao, K, Kawai, H, Fukai, Y, Kanagawa, M, Inoue, Y, Baba, S, Kawai, G. | | Deposit date: | 2013-02-28 | | Release date: | 2014-01-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Structures and reaction mechanisms of the two related enzymes, PurN and PurU
J.Biochem., 154, 2013
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3WZD
 | | KDR in complex with ligand lenvatinib | | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide, ... | | Authors: | Okamoto, K, Ikemori_Kawada, M, Inoue, A, Matsui, J. | | Deposit date: | 2014-09-24 | | Release date: | 2015-05-27 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.
ACS MED.CHEM.LETT., 6, 2015
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3WZE
 | | KDR in complex with ligand sorafenib | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ACETATE ION, ... | | Authors: | Okamoto, K, Ikemori_Kawada, M, Inoue, A, Matsui, J. | | Deposit date: | 2014-09-24 | | Release date: | 2015-05-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.
ACS MED.CHEM.LETT., 6, 2015
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2YWR
 | | Crystal structure of GAR transformylase from Aquifex aeolicus | | Descriptor: | COBALT (II) ION, MAGNESIUM ION, Phosphoribosylglycinamide formyltransferase | | Authors: | Kanagawa, M, Baba, S, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-04-23 | | Release date: | 2007-10-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Structures and reaction mechanisms of the two related enzymes, PurN and PurU.
J.Biochem., 154, 2013
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2D9H
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2DLX
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2Z4P
 | | Crystal structure of FFRP-DM1 | | Descriptor: | 75aa long hypothetical regulatory protein AsnC, ISOLEUCINE | | Authors: | Yamada, M, Koike, H, Kudo, N, Suzuki, M. | | Deposit date: | 2007-06-21 | | Release date: | 2007-09-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | A Structural Code for Discriminating between Transcription Signals Revealed by the Feast/Famine Regulatory Protein DM1 in Complex with Ligands
Structure, 15, 2007
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3AV3
 | | Crystal structure of glycinamide ribonucleotide transformylase 1 from Geobacillus kaustophilus | | Descriptor: | MAGNESIUM ION, Phosphoribosylglycinamide formyltransferase | | Authors: | Kanagawa, M, Baba, S, Nakagawa, N, Ebihara, A, Kuramitsu, S, Yokoyama, S, Sampei, G, Kawai, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2011-02-18 | | Release date: | 2012-03-07 | | Last modified: | 2014-01-15 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structures and reaction mechanisms of the two related enzymes, PurN and PurU.
J.Biochem., 154, 2013
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2D9J
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2D1J
 | | Factor Xa in complex with the inhibitor 2-[[4-[(5-chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide | | Descriptor: | 2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE, CALCIUM ION, Coagulation factor X, ... | | Authors: | Suzuki, M. | | Deposit date: | 2005-08-24 | | Release date: | 2006-08-24 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.
Bioorg.Med.Chem., 13, 2005
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2DCM
 | | The Crystal Structure of S603A Mutated Prolyl Tripeptidyl Aminopeptidase Complexed with Substrate | | Descriptor: | GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE, dipeptidyl aminopeptidase IV, putative | | Authors: | Nakajima, Y, Ito, K, Xu, Y, Yamada, N, Onohara, Y, Yoshimoto, T. | | Deposit date: | 2006-01-09 | | Release date: | 2006-09-19 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal Structure and Mechanism of Tripeptidyl Activity of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis
J.Mol.Biol., 362, 2006
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2D5L
 | | Crystal Structure of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis | | Descriptor: | SULFATE ION, dipeptidyl aminopeptidase IV, putative | | Authors: | Nakajima, Y, Ito, K, Xu, Y, Yamada, N, Onohara, Y, Yoshimoto, T. | | Deposit date: | 2005-11-02 | | Release date: | 2006-09-19 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure and Mechanism of Tripeptidyl Activity of Prolyl Tripeptidyl Aminopeptidase from Porphyromonas gingivalis
J.Mol.Biol., 362, 2006
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