7CME

Crystal structure of human P-cadherin MEC12 (X dimer) in complex with 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine (inhibitor)

Summary for 7CME

• Entry DOI: 10.2210/pdb7cme/pdb
• Descriptor: Cadherin-3, DIMETHYL SULFOXIDE, 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, cell adhesion
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 47866.82

Authors

Senoo, A.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K. (deposition date: 2020-07-27, release date: 2021-09-15, Last modification date: 2023-11-29)

• Primary citation: Senoo, A.,Ito, S.,Nagatoishi, S.,Saito, Y.,Ueno, G.,Kuroda, D.,Yoshida, K.,Tashima, T.,Kudo, S.,Sando, S.,Tsumoto, K.; Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion; Commun Biol, 4:1041-, 2021; DOI: 10.1038/s42003-021-02575-3

Experimental method

X-RAY DIFFRACTION (2.45 Å)