3WZE

KDR in complex with ligand sorafenib

Summary for 3WZE

• Entry DOI: 10.2210/pdb3wze/pdb
• Related: 3WZD
• Descriptor: Vascular endothelial growth factor receptor 2, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ACETATE ION, ... (5 entities in total)
• Functional Keywords: kdr receptor kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• Total number of polymer chains: 1
• Total formula weight: 36018.91

Authors

Okamoto, K.,Ikemori_Kawada, M.,Inoue, A.,Matsui, J. (deposition date: 2014-09-24, release date: 2015-05-27)

• Primary citation: Okamoto, K.,Ikemori-Kawada, M.,Jestel, A.,von Konig, K.,Funahashi, Y.,Matsushima, T.,Tsuruoka, A.,Inoue, A.,Matsui, J.; Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.; ACS MED.CHEM.LETT., 6:89-94, 2015; PubMed: 25589937; DOI: 10.1021/ml500394m

Experimental method

X-RAY DIFFRACTION (1.9 Å)