3WZE
KDR in complex with ligand sorafenib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vascular endothelial growth factor receptor 2 | polymer | 309 | 35340.8 | 1 | UniProt (P35968) Pfam (PF07714) | Homo sapiens (human) | VEGFR-2, Fetal liver kinase 1, FLK-1, Kinase insert domain receptor, KDR, Protein-tyrosine kinase receptor flk-1 |
| 2 | B (A) | 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE | non-polymer | 464.8 | 1 | Chemie (BAX) | |||
| 3 | C (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | D (A) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 5 | E (A) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 814 - 1172 (UniProt: P35968)
| PDB | External Database | Details |
|---|---|---|
| Val 940 | Thr 940 | engineered mutation |
| - | Lys 941 | deletion |
| - | Gly 942 | deletion |
| - | Ala 943 | deletion |
| - | Arg 944 | deletion |
| - | Phe 945 | deletion |
| - | Arg 946 | deletion |
| - | Gln 947 | deletion |
| - | Gly 948 | deletion |
| - | Lys 949 | deletion |
| - | Asp 950 | deletion |
| - | Tyr 951 | deletion |
| - | Val 952 | deletion |
| - | Gly 953 | deletion |
| - | Ala 954 | deletion |
| - | Ile 955 | deletion |
| - | Pro 956 | deletion |
| - | Val 957 | deletion |
| - | Asp 958 | deletion |
| - | Leu 959 | deletion |
| - | Lys 960 | deletion |
| - | Arg 961 | deletion |
| - | Arg 962 | deletion |
| - | Leu 963 | deletion |
| - | Asp 964 | deletion |
| - | Ser 965 | deletion |
| - | Ile 966 | deletion |
| - | Thr 967 | deletion |
| - | Ser 968 | deletion |
| - | Ser 969 | deletion |
| - | Gln 970 | deletion |
| - | Ser 971 | deletion |
| - | Ser 972 | deletion |
| - | Ala 973 | deletion |
| - | Ser 974 | deletion |
| - | Ser 975 | deletion |
| - | Gly 976 | deletion |
| - | Phe 977 | deletion |
| - | Val 978 | deletion |
| - | Glu 979 | deletion |
| - | Glu 980 | deletion |
| - | Lys 981 | deletion |
| - | Ser 982 | deletion |
| - | Leu 983 | deletion |
| - | Ser 984 | deletion |
| - | Asp 985 | deletion |
| - | Glu 987 | deletion |
| - | Glu 988 | deletion |
| - | Glu 989 | deletion |
| - | Glu 990 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35340.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 678.1 | |
| All* | Total formula weight | 36018.9 |
