7CMF

Crystal structure of human P-cadherin REC12 (monomer) in complex with 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine (inhibitor)

Summary for 7CMF

Entry DOI	10.2210/pdb7cmf/pdb
Descriptor	Cadherin-3, CALCIUM ION, 2-(5-chloro-2-methyl-1H-indol-3-yl)ethan-1-amine, ... (4 entities in total)
Functional Keywords	inhibitor, complex, cell adhesion
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	23817.01
Authors	Senoo, A.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K. (deposition date: 2020-07-27, release date: 2021-09-15, Last modification date: 2023-11-29)
Primary citation	Senoo, A.,Ito, S.,Nagatoishi, S.,Saito, Y.,Ueno, G.,Kuroda, D.,Yoshida, K.,Tashima, T.,Kudo, S.,Sando, S.,Tsumoto, K. Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion Commun Biol, 4:1041-, 2021 Cited by DOI: 10.1038/s42003-021-02575-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation