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2QTS
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BU of 2qts by Molmil
Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel, CHLORIDE ION, ...
Authors:Jasti, J, Furukawa, H, Gonzales, E.B, Gouaux, E.
Deposit date:2007-08-02
Release date:2007-09-25
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Nature, 449, 2007
1N0T
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BU of 1n0t by Molmil
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution.
Descriptor: (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, ACETATE ION, Glutamate receptor 2, ...
Authors:Hogner, A, Greenwood, J.R, Liljefors, T, Lunn, M.-L, Egebjerg, J, Larsen, I.K, Gouaux, E, Kastrup, J.S.
Deposit date:2002-10-15
Release date:2003-03-04
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.
J.Med.Chem., 46, 2003
8G4N
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BU of 8g4n by Molmil
Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroids
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, DODECANE, ...
Authors:Sun, C, Gouaux, E.
Deposit date:2023-02-10
Release date:2023-09-20
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (2.67 Å)
Cite:Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Nature, 622, 2023
8G4X
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BU of 8g4x by Molmil
Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Sun, C, Gouaux, E.
Deposit date:2023-02-10
Release date:2023-09-20
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.56 Å)
Cite:Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Nature, 622, 2023
8G5F
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BU of 8g5f by Molmil
Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1, ...
Authors:Sun, C, Gouaux, E.
Deposit date:2023-02-13
Release date:2023-09-20
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Nature, 622, 2023
8G5G
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BU of 8g5g by Molmil
Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1, ...
Authors:Sun, C, Gouaux, E.
Deposit date:2023-02-13
Release date:2023-09-20
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Nature, 622, 2023
8G4O
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BU of 8g4o by Molmil
Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with didesethylflurazepam and endogenous GABA
Descriptor: (5M)-1-(2-aminoethyl)-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Sun, C, Gouaux, E.
Deposit date:2023-02-10
Release date:2023-09-20
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Nature, 622, 2023
8G5H
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BU of 8g5h by Molmil
Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1, ...
Authors:Sun, C, Gouaux, E.
Deposit date:2023-02-13
Release date:2023-09-20
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Nature, 622, 2023
1NNK
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BU of 1nnk by Molmil
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.
Descriptor: 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE, CHLORIDE ION, Glutamate receptor 2, ...
Authors:Lunn, M.-L, Hogner, A, Stensbol, T.B, Gouaux, E, Egebjerg, J, Kastrup, J.S.
Deposit date:2003-01-14
Release date:2003-03-04
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity.
J.Med.Chem., 46, 2003
6VTK
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BU of 6vtk by Molmil
Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a desensitized state at low pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1
Authors:Yoder, N, Gouaux, E.
Deposit date:2020-02-12
Release date:2020-03-11
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity.
Elife, 9, 2020
1MS7
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BU of 1ms7 by Molmil
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate
Descriptor: (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID, Glutamate receptor subunit 2, ZINC ION
Authors:Kasper, C, Lunn, M.-L, Liljefors, T, Gouaux, E, Egebjerg, J, Kastrup, J.S.
Deposit date:2002-09-19
Release date:2003-07-08
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists
FEBS Lett., 531, 2002
6VTL
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BU of 6vtl by Molmil
Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a resting state at high pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1
Authors:Yoder, N, Gouaux, E.
Deposit date:2020-02-12
Release date:2020-03-11
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity.
Elife, 9, 2020
1NNP
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BU of 1nnp by Molmil
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.
Descriptor: 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE, Glutamate receptor 2, SULFATE ION
Authors:Lunn, M.L, Hogner, A, Stensbol, T.B, Gouaux, E, Egebjerg, J, Kastrup, J.S.
Deposit date:2003-01-14
Release date:2003-03-11
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity.
J.Med.Chem., 46, 2003
7U2N
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BU of 7u2n by Molmil
A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-open state
Descriptor: Glycine receptor subunit alphaZ1, aminomethanesulfonic acid, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhu, H, Gouaux, E.
Deposit date:2022-02-24
Release date:2023-03-08
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-open state
To Be Published
7U2M
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BU of 7u2m by Molmil
A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-desenstized state
Descriptor: Glycine receptor subunit alphaZ1, aminomethanesulfonic acid, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhu, H, Gouaux, E.
Deposit date:2022-02-24
Release date:2023-03-08
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-desenstized state
To Be Published
1FTJ
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BU of 1ftj by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION
Descriptor: GLUTAMATE RECEPTOR SUBUNIT 2, GLUTAMIC ACID, ZINC ION
Authors:Armstrong, N, Gouaux, E.
Deposit date:2000-09-12
Release date:2000-11-01
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
1FW0
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BU of 1fw0 by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH KAINATE AT 2.0 A RESOLUTION
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR SUBUNIT 2
Authors:Armstrong, N, Gouaux, E.
Deposit date:2000-09-20
Release date:2000-11-15
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
1FTO
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BU of 1fto by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN THE APO STATE AT 2.0 A RESOLUTION
Descriptor: GLUTAMATE RECEPTOR SUBUNIT 2
Authors:Armstrong, N, Gouaux, E.
Deposit date:2000-09-12
Release date:2000-11-01
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
1FTL
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BU of 1ftl by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH THE ANTAGONIST DNQX AT 1.8 A RESOLUTION
Descriptor: 6,7-DINITROQUINOXALINE-2,3-DIONE, GLUTAMATE RECEPTOR SUBUNIT 2, SULFATE ION
Authors:Armstrong, N, Gouaux, E.
Deposit date:2000-09-12
Release date:2000-11-01
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
3M2L
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BU of 3m2l by Molmil
Crystal structure of the M113F mutant of alpha-hemolysin
Descriptor: Alpha-hemolysin
Authors:Montoya, M, Gouaux, E.
Deposit date:2010-03-07
Release date:2010-05-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.
Proc.Natl.Acad.Sci.USA, 107, 2010
3M4D
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BU of 3m4d by Molmil
Crystal structure of the M113N mutant of alpha-hemolysin
Descriptor: Alpha-hemolysin
Authors:Montoya, M, Gouaux, E.
Deposit date:2010-03-10
Release date:2010-05-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.
Proc.Natl.Acad.Sci.USA, 107, 2010
3M3R
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BU of 3m3r by Molmil
Crystal structure of the M113F alpha-hemolysin mutant complexed with beta-cyclodextrin
Descriptor: Alpha-hemolysin, Cycloheptakis-(1-4)-(alpha-D-glucopyranose)
Authors:Montoya, M, Gouaux, E.
Deposit date:2010-03-09
Release date:2010-05-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.
Proc.Natl.Acad.Sci.USA, 107, 2010
3M4E
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BU of 3m4e by Molmil
Crystal structure of the M113N mutant of alpha-hemolysin bound to beta-cyclodextrin
Descriptor: Alpha-hemolysin, Cycloheptakis-(1-4)-(alpha-D-glucopyranose)
Authors:Montoya, M, Gouaux, E.
Deposit date:2010-03-10
Release date:2010-05-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores.
Proc.Natl.Acad.Sci.USA, 107, 2010
4DW0
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BU of 4dw0 by Molmil
Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 2.9 Angstroms
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GADOLINIUM ATOM, GLYCEROL, ...
Authors:Hattori, M, Gouaux, E.
Deposit date:2012-02-24
Release date:2012-04-25
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular mechanism of ATP binding and ion channel activation in P2X receptors.
Nature, 485, 2012
1M5B
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BU of 1m5b by Molmil
X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-Me-Tet-AMPA AT 1.85 A RESOLUTION.
Descriptor: (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID, Glutamate receptor 2, ZINC ION
Authors:Hogner, A, Kastrup, J.S, Jin, R, Liljefors, T, Mayer, M.L, Egebjerg, J, Larsen, I.K, Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002

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