8G5H

Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroid

This is a non-PDB format compatible entry.

Summary for 8G5H

• Entry DOI: 10.2210/pdb8g5h/pdb
• EMDB information: 29743
• Descriptor: Gamma-aminobutyric acid receptor subunit beta-2, GAMMA-AMINO-BUTANOIC ACID, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... (14 entities in total)
• Functional Keywords: ligand-gated ion channel, cys-loop receptor, neurotransmitter receptor, membrane protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 7
• Total formula weight: 337661.30

Authors

Sun, C.,Gouaux, E. (deposition date: 2023-02-13, release date: 2023-09-20, Last modification date: 2023-11-15)

• Primary citation: Sun, C.,Zhu, H.,Clark, S.,Gouaux, E.; Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.; Nature, 622:195-201, 2023; PubMed: 37730991; DOI: 10.1038/s41586-023-06556-w

Experimental method

ELECTRON MICROSCOPY (2.89 Å)