8G5G

Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroid

This is a non-PDB format compatible entry.

Summary for 8G5G

• Entry DOI: 10.2210/pdb8g5g/pdb
• EMDB information: 29742
• Descriptor: Gamma-aminobutyric acid receptor subunit alpha-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... (15 entities in total)
• Functional Keywords: ligand-gated ion channel, cys-loop receptor, neurotransmitter receptor, membrane protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 7
• Total formula weight: 337499.16

Authors

Sun, C.,Gouaux, E. (deposition date: 2023-02-13, release date: 2023-09-20, Last modification date: 2023-11-15)

• Primary citation: Sun, C.,Zhu, H.,Clark, S.,Gouaux, E.; Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.; Nature, 622:195-201, 2023; PubMed: 37730991; DOI: 10.1038/s41586-023-06556-w

Experimental method

ELECTRON MICROSCOPY (2.94 Å)