8G4X
Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone
This is a non-PDB format compatible entry.
Summary for 8G4X
| Entry DOI | 10.2210/pdb8g4x/pdb |
| EMDB information | 29733 |
| Descriptor | Gamma-aminobutyric acid receptor subunit alpha-1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (15 entities in total) |
| Functional Keywords | ligand-gated ion channel, cys-loop receptor, neurotransmitter receptor, membrane protein |
| Biological source | Mus musculus More |
| Total number of polymer chains | 7 |
| Total formula weight | 337023.84 |
| Authors | Sun, C.,Gouaux, E. (deposition date: 2023-02-10, release date: 2023-09-20, Last modification date: 2023-11-15) |
| Primary citation | Sun, C.,Zhu, H.,Clark, S.,Gouaux, E. Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622:195-201, 2023 Cited by PubMed: 37730991DOI: 10.1038/s41586-023-06556-w PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.56 Å) |
Structure validation
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