8G4X

Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA and allopregnanolone

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004890	molecular_function	GABA-A receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0007214	biological_process	gamma-aminobutyric acid signaling pathway
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004890	molecular_function	GABA-A receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0004890	molecular_function	GABA-A receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006821	biological_process	chloride transport
C	0007214	biological_process	gamma-aminobutyric acid signaling pathway
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0004890	molecular_function	GABA-A receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006821	biological_process	chloride transport
D	0007214	biological_process	gamma-aminobutyric acid signaling pathway
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004890	molecular_function	GABA-A receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMhLedFPmDvhaC

Chain	Residue	Details
C	CYS163-CYS177
A	CYS138-CYS152
D	CYS151-CYS165
B	CYS136-CYS150

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR191-HIS197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	268
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
C	GLN1-LYS246
C	ARG298-THR308
C	VAL451-GLN464

---

site_id	SWS_FT_FI2
Number of Residues	79
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	ILE247-VAL267
C	ALA278-ALA297
C	ALA309-ALA329
C	ILE430-TYR450
E	PHE221-ILE242
E	ALA246-LEU268
E	ALA280-VAL302
E	TRP466-VAL487

---

site_id	SWS_FT_FI3
Number of Residues	108
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
C	SER268-PRO277
C	THR330-LYS429

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P14867

Chain	Residue	Details
C	ARG91
B	SER156
B	THR202
E	TYR97
E	SER156
E	THR202

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P62813

Chain	Residue	Details
C	THR154
D	ASN90
D	ASN208

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
C	SER398
C	SER405
C	SER414

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
C	THR399
B	ASN80
B	ASN149
E	ASN8
E	ASN80
E	ASN149

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN35
C	ASN135
C	ASN148
C	ASN200

---