8JN4
 
 | | Cryo-EM structure of dengue virus serotype 3 strain 863DK in complex with human antibody DENV-290 Fab at 4 deg C (subparticle LLR-LRR) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein, Human antibody DENV-290 heavy chain, ... | | Authors: | Fibriansah, G, Ng, T.S, Tan, A.W.K, Shi, J, Lok, S.M. | | Deposit date: | 2023-06-06 | | Release date: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Ultrapotent human antibodies lock E protein dimers of diverse DENV3 morphological variants
To Be Published
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3J6T
 | | Cryo-EM structure of Dengue virus serotype 3 at 37 degrees C | | Descriptor: | envelope protein, membrane protein | | Authors: | Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M. | | Deposit date: | 2014-03-25 | | Release date: | 2015-03-04 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
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3J6S
 | | Cryo-EM structure of Dengue virus serotype 3 at 28 degrees C | | Descriptor: | envelope protein, membrane protein | | Authors: | Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M. | | Deposit date: | 2014-03-24 | | Release date: | 2015-03-04 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
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3J6U
 | | Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab | | Descriptor: | Fab 5J7 heavy chain, Fab 5J7 light chain, envelope protein, ... | | Authors: | Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M. | | Deposit date: | 2014-03-26 | | Release date: | 2015-03-04 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (9 Å) | | Cite: | A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
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5KW9
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8DBZ
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8EKD
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4HG4
 | | Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 2G1 heavy chain, ... | | Authors: | Xu, R, Wilson, I.A. | | Deposit date: | 2012-10-06 | | Release date: | 2013-02-13 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin.
Nat.Struct.Mol.Biol., 20, 2013
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4M4Y
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4L8I
 | | Crystal structure of RSV epitope scaffold FFL_005 | | Descriptor: | RSV epitope scaffold FFL_005 | | Authors: | Jardine, J, Correnti, C, Holmes, M.A, Strong, R.K, Schief, W.R. | | Deposit date: | 2013-06-17 | | Release date: | 2014-02-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Proof of principle for epitope-focused vaccine design.
Nature, 507, 2014
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4JLR
 | | Crystal structure of a designed Respiratory Syncytial Virus Immunogen in complex with Motavizumab | | Descriptor: | Motavizumab Fab heavy chain, Motavizumab Fab light chain, PENTAETHYLENE GLYCOL, ... | | Authors: | Rupert, P.B, Correia, B, Schief, W, Strong, R.K. | | Deposit date: | 2013-03-12 | | Release date: | 2014-02-05 | | Last modified: | 2014-12-17 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Proof of principle for epitope-focused vaccine design.
Nature, 507, 2014
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4HFU
 | | Crystal structure of Fab 8M2 in complex with a H2N2 influenza virus hemagglutinin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 8M2 heavy chain, Fab 8M2 light chain, ... | | Authors: | Xu, R, Wilson, I.A. | | Deposit date: | 2012-10-05 | | Release date: | 2013-02-13 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.106 Å) | | Cite: | A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin.
Nat.Struct.Mol.Biol., 20, 2013
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4GXU
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4N9G
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4GXV
 | | Crystal structure of anti-influenza virus antibody 1F1 | | Descriptor: | Antibody 1F1, heavy chain, light chain | | Authors: | Ekiert, D.C, Wilson, I.A. | | Deposit date: | 2012-09-04 | | Release date: | 2012-12-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.449 Å) | | Cite: | Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses.
Plos Pathog., 8, 2012
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4M5Z
 | | Crystal structure of broadly neutralizing antibody 5J8 bound to 2009 pandemic influenza hemagglutinin, HA1 subunit | | Descriptor: | Fab 5J8 heavy chain, Fab 5J8 light chain, Hemagglutinin HA1 chain | | Authors: | Hong, M, Lee, P.S, Wilson, I.A. | | Deposit date: | 2013-08-08 | | Release date: | 2013-09-25 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site.
J.Virol., 87, 2013
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4HF5
 | | Crystal structure of Fab 8F8 in complex a H2N2 influenza virus hemagglutinin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 8F8 heavy chain, Fab 8F8 light chain, ... | | Authors: | Xu, R, Wilson, I.A. | | Deposit date: | 2012-10-04 | | Release date: | 2013-02-13 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.004 Å) | | Cite: | A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin.
Nat.Struct.Mol.Biol., 20, 2013
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4GSD
 | | H5.3 Fab Structure | | Descriptor: | H5.3 Fab Heavy Chain, H5.3 Fab Light Chain | | Authors: | Spiller, B.W, Winarski, K.L. | | Deposit date: | 2012-08-27 | | Release date: | 2013-08-21 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.251 Å) | | Cite: | Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses.
J.Clin.Invest., 123, 2013
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4M5Y
 | | Crystal structure of broadly neutralizing Fab 5J8 | | Descriptor: | DI(HYDROXYETHYL)ETHER, Fab 5J8 heavy chain, Fab 5J8 light chain, ... | | Authors: | Lee, P.S, Wilson, I.A. | | Deposit date: | 2013-08-08 | | Release date: | 2013-09-25 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site.
J.Virol., 87, 2013
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4XNM
 | | Antibody Influenza H5 Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, H5.3 FAB Heavy Chain, H5.3 FAB Light Chain, ... | | Authors: | Winarski, K.L, Spiler, B.W. | | Deposit date: | 2015-01-15 | | Release date: | 2015-07-15 | | Last modified: | 2022-03-30 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5XRQ
 | | Crystal structure of human monoclonal antibody H3v-47 | | Descriptor: | Fab H3v-47 heavy chain, Fab H3v-47 light chain | | Authors: | Zhang, H, Willson, I.A. | | Deposit date: | 2017-06-09 | | Release date: | 2018-07-25 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
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5XRS
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5XRT
 | | Crystal structure of A/Minnesota/11/2010 (H3N2) influenza virus hemagglutinin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhang, H, Wilson, I.A. | | Deposit date: | 2017-06-09 | | Release date: | 2018-07-25 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
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6OZ9
 | | Ebola virus glycoprotein in complex with EBOV-520 Fab | | Descriptor: | EBOV-520 Fab heavy chain, EBOV-520 Fab light chain, Envelope glycoprotein, ... | | Authors: | Milligan, J.C, Altman, P.X, Hui, S, Hastie, K.M, Gilchuk, P, Crowe, J.E, Saphire, E.O. | | Deposit date: | 2019-05-15 | | Release date: | 2020-03-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.462 Å) | | Cite: | Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Immunity, 52, 2020
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6P9J
 | | crystal structure of human anti staphylococcus aureus antibody STAU-229 Fab | | Descriptor: | TRIS(HYDROXYETHYL)AMINOMETHANE, human anti staphylococcus aureus antibody STAU-229 Fab heavy chain, human anti staphylococcus aureus antibody STAU-229 Fab light chain | | Authors: | Dong, J, Crowe, J.E. | | Deposit date: | 2019-06-10 | | Release date: | 2020-06-17 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Human V H 1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis.
Mbio, 10, 2019
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