Crystal structure of RSV epitope scaffold FFL_005

Summary for 4L8I

DescriptorRSV epitope scaffold FFL_005 (2 entities in total)
Functional Keywordsthree-helix bundle, immune system
Biological sourcesynthetic construct
Total number of polymer chains2
Total molecular weight27419.51
Jardine, J.,Correnti, C.,Holmes, M.A.,Strong, R.K.,Schief, W.R. (deposition date: 2013-06-17, release date: 2014-02-12, Last modification date: 2017-11-15)
Primary citation
Correia, B.E.,Bates, J.T.,Loomis, R.J.,Baneyx, G.,Carrico, C.,Jardine, J.G.,Rupert, P.,Correnti, C.,Kalyuzhniy, O.,Vittal, V.,Connell, M.J.,Stevens, E.,Schroeter, A.,Chen, M.,Macpherson, S.,Serra, A.M.,Adachi, Y.,Holmes, M.A.,Li, Y.,Klevit, R.E.,Graham, B.S.,Wyatt, R.T.,Baker, D.,Strong, R.K.,Crowe, J.E.,Johnson, P.R.,Schief, W.R.
Proof of principle for epitope-focused vaccine design.
Nature, 507:201-206, 2014
PubMed: 24499818 (PDB entries with the same primary citation)
DOI: 10.1038/nature12966
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.267100.6%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution