6MO0
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![BU of 6mo0 by Molmil](/molmil-images/mine/6mo0) | Structure of dengue virus protease with an allosteric Inhibitor that blocks replication | Descriptor: | 1-(4-{3-[4-(furan-3-yl)phenyl]-5-[(piperidin-4-yl)methoxy]pyrazin-2-yl}phenyl)methanamine, FLAVIVIRUS_NS2B/Peptidase S7 | Authors: | Lin, Y.-L, Nie, S, Hua, Y, Wu, J, Wu, F, Huo, T, Yao, Y, Song, Y. | Deposit date: | 2018-10-03 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J. Am. Chem. Soc., 141, 2019
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3DET
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![BU of 3det by Molmil](/molmil-images/mine/3det) | Structure of the E148A, Y445A doubly ungated mutant of E.coli CLC_Ec1, Cl-/H+ antiporter | Descriptor: | Fab fragment, Heavy chain, Light chain, ... | Authors: | Jayaram, H, Accardi, A, Wu, F, Williams, C, Miller, C. | Deposit date: | 2008-06-10 | Release date: | 2008-06-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger Proc.Natl.Acad.Sci.USA, 105, 2008
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3NCY
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![BU of 3ncy by Molmil](/molmil-images/mine/3ncy) | X-ray crystal structure of an arginine agmatine antiporter (AdiC) in complex with a Fab fragment | Descriptor: | AdiC, Fab Heavy chain, Fab Light chain | Authors: | Fang, Y, Jayaram, H, Shane, T, Komalkova-Partensky, L, Wu, F, Williams, C, Xiong, Y, Miller, C. | Deposit date: | 2010-06-06 | Release date: | 2010-08-18 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of a prokaryotic virtual proton pump at 3.2 A resolution. Nature, 460, 2009
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3ND0
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![BU of 3nd0 by Molmil](/molmil-images/mine/3nd0) | X-ray crystal structure of a slow cyanobacterial Cl-/H+ antiporter | Descriptor: | CHLORIDE ION, Sll0855 protein | Authors: | Jayaram, H, Robertson, J, Wu, F, Williams, C, Miller, C. | Deposit date: | 2010-06-06 | Release date: | 2011-01-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of a Slow CLC Cl(-)/H(+) Antiporter from a Cyanobacterium. Biochemistry, 50, 2011
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7W6V
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![BU of 7w6v by Molmil](/molmil-images/mine/7w6v) | Crystal structure of a dicobalt-substituted small laccase at 2.47 angstrom | Descriptor: | COBALT (II) ION, Putative copper oxidase | Authors: | Yang, X, Wu, F, Wu, W, Chen, X, Fan, S, Yu, P, Mao, L. | Deposit date: | 2021-12-02 | Release date: | 2022-11-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | A versatile artificial metalloenzyme scaffold enabling direct bioelectrocatalysis in solution. Sci Adv, 8, 2022
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2LW3
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![BU of 2lw3 by Molmil](/molmil-images/mine/2lw3) | Solution structure of the soluble domain of MmpS4 from Mycobacterium tuberculosis | Descriptor: | Putative membrane protein mmpS4 | Authors: | Xi, Z, Sun, P, Wang, W, Lai, C, Wu, F, Tian, C. | Deposit date: | 2012-07-19 | Release date: | 2013-03-13 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis Plos Pathog., 9, 2013
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2M0Q
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![BU of 2m0q by Molmil](/molmil-images/mine/2m0q) | Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix | Descriptor: | Potassium voltage-gated channel subfamily E member 2 | Authors: | Lai, C, Li, P, Chen, L, Zhang, L, Wu, F, Tian, C. | Deposit date: | 2012-11-01 | Release date: | 2014-04-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2. Sci Rep, 4, 2014
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7DTY
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![BU of 7dty by Molmil](/molmil-images/mine/7dty) | Structural basis of ligand selectivity conferred by the human glucose-dependent insulinotropic polypeptide receptor | Descriptor: | CHOLESTEROL, Gastric inhibitory polypeptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, F.H, Zhang, C, Zhou, Q.T, Hang, K.N, Zou, X.Y, Chen, Y, Wu, F, Rao, Q.D, Dai, A.T, Yin, W.C, Shen, D.D, Zhang, Y, Xia, T, Stevens, R.C, Xu, H.E, Yang, D.H, Zhao, L.H, Wang, M.W. | Deposit date: | 2021-01-06 | Release date: | 2021-08-04 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor. Elife, 10, 2021
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2MRM
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5ZID
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![BU of 5zid by Molmil](/molmil-images/mine/5zid) | Crystal Structure of human DPP-IV in complex with HL2 | Descriptor: | (2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... | Authors: | Zhu, L, Li, H, Wu, F. | Deposit date: | 2018-03-14 | Release date: | 2019-03-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal Structure of human DPP-IV in complex with HL2 To Be Published
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2MJY
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![BU of 2mjy by Molmil](/molmil-images/mine/2mjy) | Solution structure of synthetic Mamba-1 peptide | Descriptor: | Mambalgin-1 | Authors: | He, Y, Wu, F, Tian, C. | Deposit date: | 2014-01-21 | Release date: | 2015-01-28 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1 Chem.Commun.(Camb.), 50, 2014
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7XMN
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![BU of 7xmn by Molmil](/molmil-images/mine/7xmn) | Structure of SARS-CoV-2 ORF8 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Maltodextrin-binding protein, ... | Authors: | Chen, X, Xu, W. | Deposit date: | 2022-04-26 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Glycosylated, Lipid-Binding, CDR-Like Domains of SARS-CoV-2 ORF8 Indicate Unique Sites of Immune Regulation. Microbiol Spectr, 11, 2023
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5AZF
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![BU of 5azf by Molmil](/molmil-images/mine/5azf) | Crystal structure of LGG-1 complexed with a WEEL peptide | Descriptor: | CADMIUM ION, Protein lgg-1, SULFATE ION, ... | Authors: | Watanabe, Y, Noda, N.N. | Deposit date: | 2015-10-05 | Release date: | 2015-12-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Mol.Cell, 60, 2015
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5AZH
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![BU of 5azh by Molmil](/molmil-images/mine/5azh) | Crystal structure of LGG-2 fused with an EEEWEEL peptide | Descriptor: | EEEWEEL peptide,Protein lgg-2, MAGNESIUM ION | Authors: | Watanabe, Y, Fujioka, Y, Noda, N.N. | Deposit date: | 2015-10-05 | Release date: | 2015-12-30 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Mol.Cell, 60, 2015
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5AZG
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![BU of 5azg by Molmil](/molmil-images/mine/5azg) | Crystal structure of LGG-1 complexed with a UNC-51 peptide | Descriptor: | CADMIUM ION, Protein lgg-1, Serine/threonine-protein kinase unc-51 | Authors: | Watanabe, Y, Fujioka, Y, Noda, N.N. | Deposit date: | 2015-10-05 | Release date: | 2015-12-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Mol.Cell, 60, 2015
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3X1D
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![BU of 3x1d by Molmil](/molmil-images/mine/3x1d) | |
7EPX
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![BU of 7epx by Molmil](/molmil-images/mine/7epx) | S protein of SARS-CoV-2 in complex with GW01 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Shen, Y.P, Zhang, Y.Y, Yan, R.H, Li, Y.N, Zhou, Q. | Deposit date: | 2021-04-28 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses. Cell Discov, 8, 2022
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8J8K
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![BU of 8j8k by Molmil](/molmil-images/mine/8j8k) | Membrane bound PRTase, C3 symmetry, acceptor bound | Descriptor: | Decaprenyl-phosphate phosphoribosyltransferase, MONO-TRANS, OCTA-CIS DECAPRENYL-PHOSPHATE | Authors: | Wu, F.Y, Gao, S, Zhang, L, Rao, Z.H. | Deposit date: | 2023-05-01 | Release date: | 2024-02-07 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis. Nat Microbiol, 9, 2024
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8J8J
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![BU of 8j8j by Molmil](/molmil-images/mine/8j8j) | Membrane bound PRTase, C3 symmetry, donor bound | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Decaprenyl-phosphate phosphoribosyltransferase, ... | Authors: | Wu, F.Y, Gao, S, Zhang, L, Rao, Z.H. | Deposit date: | 2023-05-01 | Release date: | 2024-02-07 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis. Nat Microbiol, 9, 2024
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8Y33
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![BU of 8y33 by Molmil](/molmil-images/mine/8y33) | A near-infrared fluorescent protein of de novo backbone design | Descriptor: | 3-[5-[(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-2-[[5-[(3-ethyl-4-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{H}-pyrrol-2-yl]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, near-infrared fluorescent protein | Authors: | Hu, X, Xu, Y. | Deposit date: | 2024-01-28 | Release date: | 2024-02-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Using Protein Design and Directed Evolution to Monomerize a Bright Near-Infrared Fluorescent Protein. Acs Synth Biol, 13, 2024
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8J1X
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![BU of 8j1x by Molmil](/molmil-images/mine/8j1x) | |
8J1W
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![BU of 8j1w by Molmil](/molmil-images/mine/8j1w) | |
3DEH
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![BU of 3deh by Molmil](/molmil-images/mine/3deh) | Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors | Descriptor: | Caspase-3, isoquinoline-1,3,4(2H)-trione | Authors: | Wu, J, Du, J, Li, J, Ding, J. | Deposit date: | 2008-06-10 | Release date: | 2008-09-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
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3DEJ
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![BU of 3dej by Molmil](/molmil-images/mine/3dej) | Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors | Descriptor: | (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 | Authors: | Wu, J, Du, J, Li, J, Ding, J. | Deposit date: | 2008-06-10 | Release date: | 2008-09-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
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3DEI
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![BU of 3dei by Molmil](/molmil-images/mine/3dei) | Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors | Descriptor: | (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 | Authors: | Wu, J, Du, J, Li, J, Ding, J. | Deposit date: | 2008-06-10 | Release date: | 2008-09-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
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