6MO0
Structure of dengue virus protease with an allosteric Inhibitor that blocks replication
Summary for 6MO0
Entry DOI | 10.2210/pdb6mo0/pdb |
Descriptor | FLAVIVIRUS_NS2B/Peptidase S7, 1-(4-{3-[4-(furan-3-yl)phenyl]-5-[(piperidin-4-yl)methoxy]pyrazin-2-yl}phenyl)methanamine (2 entities in total) |
Functional Keywords | allosteric inhibitor, inhibitor, complex, protease, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Dengue virus 2 More |
Total number of polymer chains | 2 |
Total formula weight | 53542.07 |
Authors | |
Primary citation | Yao, Y.,Huo, T.,Lin, Y.L.,Nie, S.,Wu, F.,Hua, Y.,Wu, J.,Kneubehl, A.R.,Vogt, M.B.,Rico-Hesse, R.,Song, Y. Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J. Am. Chem. Soc., 141:6832-6836, 2019 Cited by PubMed: 31017399DOI: 10.1021/jacs.9b02505 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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